Tags

Type your tag names separated by a space and hit enter

Dietary fat intake and risk of non-Hodgkin lymphoma in 2 large prospective cohorts.
Am J Clin Nutr 2017; 106(2):650-656AJ

Abstract

Background:

Dietary fat intake may contribute to non-Hodgkin lymphoma (NHL) pathogenesis by influencing carcinogen exposure or through immune modulation.

Objective:

We aimed to evaluate NHL risk associated with total and specific dietary fat intake.

Design:

We evaluated associations within the Nurses' Health Study (NHS) (n = 88,598) and the Health Professionals Follow-Up Study (HPFS) (n = 47,531) using repeated validated dietary assessments. We confirmed 1802 incident NHL diagnoses through 2010. Using multivariable Cox proportional hazards models, we estimated hazard ratios (HRs) for all NHL and common subtypes associated with a 1-SD increase in cumulative mean intakes of total, animal, saturated, trans, and vegetable fats and marine fatty acids. We pooled sex-specific HRs using random-effects meta-analysis.

Results:

Over 24-30 y of follow-up, neither total nor specific dietary fats were significantly associated with NHL risk overall. Higher total, animal, and saturated fat intakes were positively associated with the risk of the chronic lymphocytic leukemia/small lymphocytic lymphoma subtype among women only (253 cases; P-trend ≤ 0.05), driven by strong associations during 1980-1994. From baseline through 1994, among women and men combined, total fat intake was borderline-significantly positively associated with NHL overall (pooled HR per SD: 1.13; 95% CI: 0.99, 1.29) and was significantly associated with diffuse large B cell lymphoma (pooled HR per SD: 1.47; 95% CI: 1.06, 2.05), with similar trends for animal and saturated fat intake. For women only, trans fat was significantly positively associated with all NHL. In contrast, during 1994-2010, there was little evidence for associations of dietary fat intake with NHL overall or by subtype.

Conclusion:

Previous observations of an increased risk of NHL associated with intakes of total, animal, saturated, and trans fat with 14 y of follow-up did not persist with longer follow-up.

Authors+Show Affiliations

Slone Epidemiology Center, Boston University, Boston, MA; kab15@bu.edu.Channing Division of Network Medicine and. Departments of Nutrition and. Epidemiology.Channing Division of Network Medicine and. Biostatistics, and.Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and.Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.Channing Division of Network Medicine and.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28659300

Citation

Bertrand, Kimberly A., et al. "Dietary Fat Intake and Risk of non-Hodgkin Lymphoma in 2 Large Prospective Cohorts." The American Journal of Clinical Nutrition, vol. 106, no. 2, 2017, pp. 650-656.
Bertrand KA, Giovannucci E, Rosner BA, et al. Dietary fat intake and risk of non-Hodgkin lymphoma in 2 large prospective cohorts. Am J Clin Nutr. 2017;106(2):650-656.
Bertrand, K. A., Giovannucci, E., Rosner, B. A., Zhang, S. M., Laden, F., & Birmann, B. M. (2017). Dietary fat intake and risk of non-Hodgkin lymphoma in 2 large prospective cohorts. The American Journal of Clinical Nutrition, 106(2), pp. 650-656. doi:10.3945/ajcn.117.155010.
Bertrand KA, et al. Dietary Fat Intake and Risk of non-Hodgkin Lymphoma in 2 Large Prospective Cohorts. Am J Clin Nutr. 2017;106(2):650-656. PubMed PMID: 28659300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat intake and risk of non-Hodgkin lymphoma in 2 large prospective cohorts. AU - Bertrand,Kimberly A, AU - Giovannucci,Edward, AU - Rosner,Bernard A, AU - Zhang,Shumin M, AU - Laden,Francine, AU - Birmann,Brenda M, Y1 - 2017/06/28/ PY - 2017/02/15/received PY - 2017/06/01/accepted PY - 2017/7/1/pubmed PY - 2017/8/17/medline PY - 2017/6/30/entrez KW - diet KW - epidemiology KW - fat KW - non-Hodgkin lymphoma KW - nutrition SP - 650 EP - 656 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 106 IS - 2 N2 - Background: Dietary fat intake may contribute to non-Hodgkin lymphoma (NHL) pathogenesis by influencing carcinogen exposure or through immune modulation.Objective: We aimed to evaluate NHL risk associated with total and specific dietary fat intake.Design: We evaluated associations within the Nurses' Health Study (NHS) (n = 88,598) and the Health Professionals Follow-Up Study (HPFS) (n = 47,531) using repeated validated dietary assessments. We confirmed 1802 incident NHL diagnoses through 2010. Using multivariable Cox proportional hazards models, we estimated hazard ratios (HRs) for all NHL and common subtypes associated with a 1-SD increase in cumulative mean intakes of total, animal, saturated, trans, and vegetable fats and marine fatty acids. We pooled sex-specific HRs using random-effects meta-analysis.Results: Over 24-30 y of follow-up, neither total nor specific dietary fats were significantly associated with NHL risk overall. Higher total, animal, and saturated fat intakes were positively associated with the risk of the chronic lymphocytic leukemia/small lymphocytic lymphoma subtype among women only (253 cases; P-trend ≤ 0.05), driven by strong associations during 1980-1994. From baseline through 1994, among women and men combined, total fat intake was borderline-significantly positively associated with NHL overall (pooled HR per SD: 1.13; 95% CI: 0.99, 1.29) and was significantly associated with diffuse large B cell lymphoma (pooled HR per SD: 1.47; 95% CI: 1.06, 2.05), with similar trends for animal and saturated fat intake. For women only, trans fat was significantly positively associated with all NHL. In contrast, during 1994-2010, there was little evidence for associations of dietary fat intake with NHL overall or by subtype.Conclusion: Previous observations of an increased risk of NHL associated with intakes of total, animal, saturated, and trans fat with 14 y of follow-up did not persist with longer follow-up. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/28659300/Dietary_fat_intake_and_risk_of_non_Hodgkin_lymphoma_in_2_large_prospective_cohorts_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.117.155010 DB - PRIME DP - Unbound Medicine ER -