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Respiratory microbiota and lower respiratory tract disease.
Expert Rev Anti Infect Ther. 2017 07; 15(7):703-711.ER

Abstract

INTRODUCTION

The respiratory airways harbor a complex succession of ecological niches with distinct but related bacterial communities. Particular challenges of respiratory microbiome research have led to limited scientific output compared to other human microbiomes. Areas covered: In this review, we summarize the current state of knowledge of the bacterial respiratory microbiome, with a particular focus on associations between the respiratory microbiome and lower respiratory tract conditions. Expert commentary: There is growing evidence that the respiratory microbiome is associated with lower respiratory infectious diseases and related conditions. Most respiratory microbiome reports are metataxonomic cross-sectional or case-control studies with relatively small sample sizes. Large, prospective projects with metatranscriptomics or metabolomics approach are needed to unravel the effect of the respiratory microbiome on health-related conditions. Moreover, standardization in sampling, library preparation, sequencing techniques and data analysis should be encouraged.

Authors+Show Affiliations

a Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical , Universidade Nova de Lisboa , Lisbon , Portugal. b ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB) , Hospital Clínic - Universitat de Barcelona , Barcelona , Spain.b ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB) , Hospital Clínic - Universitat de Barcelona , Barcelona , Spain. c Centro de Investigação em Saúde de Manhiça (CISM) , Maputo , Mozambique. d ICREA , Barcelona , Spain. e University Hospital Sant Joan de Deu , Barcelona , Spain.a Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical , Universidade Nova de Lisboa , Lisbon , Portugal.f Institut de Recerca Pediatrica , Hospital de Sant Joan de Dèu , Barcelona , Spain. g Ciber de Epidemiología y Salud Pública, CIBERESP , Madrid , Spain. h Department of Medicine , Universitat Internacional de Catalunya , Barcelona , Spain.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28661199

Citation

Lanaspa, Miguel, et al. "Respiratory Microbiota and Lower Respiratory Tract Disease." Expert Review of Anti-infective Therapy, vol. 15, no. 7, 2017, pp. 703-711.
Lanaspa M, Bassat Q, Medeiros MM, et al. Respiratory microbiota and lower respiratory tract disease. Expert Rev Anti Infect Ther. 2017;15(7):703-711.
Lanaspa, M., Bassat, Q., Medeiros, M. M., & Muñoz-Almagro, C. (2017). Respiratory microbiota and lower respiratory tract disease. Expert Review of Anti-infective Therapy, 15(7), 703-711. https://doi.org/10.1080/14787210.2017.1349609
Lanaspa M, et al. Respiratory Microbiota and Lower Respiratory Tract Disease. Expert Rev Anti Infect Ther. 2017;15(7):703-711. PubMed PMID: 28661199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory microbiota and lower respiratory tract disease. AU - Lanaspa,Miguel, AU - Bassat,Quique, AU - Medeiros,Marcia Melo, AU - Muñoz-Almagro,Camen, PY - 2017/7/1/pubmed PY - 2018/4/6/medline PY - 2017/6/30/entrez KW - 16S rRNA KW - Respiratory microbiome KW - asthma KW - bronchiolitis KW - lower respiratory tract infections KW - next-generation sequencing KW - pneumonia SP - 703 EP - 711 JF - Expert review of anti-infective therapy JO - Expert Rev Anti Infect Ther VL - 15 IS - 7 N2 - INTRODUCTION: The respiratory airways harbor a complex succession of ecological niches with distinct but related bacterial communities. Particular challenges of respiratory microbiome research have led to limited scientific output compared to other human microbiomes. Areas covered: In this review, we summarize the current state of knowledge of the bacterial respiratory microbiome, with a particular focus on associations between the respiratory microbiome and lower respiratory tract conditions. Expert commentary: There is growing evidence that the respiratory microbiome is associated with lower respiratory infectious diseases and related conditions. Most respiratory microbiome reports are metataxonomic cross-sectional or case-control studies with relatively small sample sizes. Large, prospective projects with metatranscriptomics or metabolomics approach are needed to unravel the effect of the respiratory microbiome on health-related conditions. Moreover, standardization in sampling, library preparation, sequencing techniques and data analysis should be encouraged. SN - 1744-8336 UR - https://www.unboundmedicine.com/medline/citation/28661199/Respiratory_microbiota_and_lower_respiratory_tract_disease_ L2 - https://www.tandfonline.com/doi/full/10.1080/14787210.2017.1349609 DB - PRIME DP - Unbound Medicine ER -