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L-dopa in the treatment of negative schizophrenic symptoms: a single-subject experimental study.
Int J Psychiatry Med 1985-1986; 15(3):293-8IJ

Abstract

Adjunctive Sinemet (L-DOPA plus carbidopa) therapy was assessed for a neuroleptic nonresponsive schizophrenic with a longstanding negative syndrome. A twenty-seven week double-blind placebo-controlled reversal design found significant improvement specifically for negative symptoms while treated with combined haloperidol-Sinemet as compared against haloperidol-placebo. The eight-week adjunctive treatment reversed a worsening trend in attention, abstract thinking, passive withdrawal, psychomotor retardation, and a cluster of seven negative parameters, while positive symptoms were unaffected. This seemed to represent more than simple reversal of drug-induced akinesia and underscores the importance of distinguishing between positive and negative syndromes in psychopharmacological research.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2866168

Citation

Kay, S R., and L A. Opler. "L-dopa in the Treatment of Negative Schizophrenic Symptoms: a Single-subject Experimental Study." International Journal of Psychiatry in Medicine, vol. 15, no. 3, 1986, pp. 293-8.
Kay SR, Opler LA. L-dopa in the treatment of negative schizophrenic symptoms: a single-subject experimental study. Int J Psychiatry Med. 1986;15(3):293-8.
Kay, S. R., & Opler, L. A. (1986). L-dopa in the treatment of negative schizophrenic symptoms: a single-subject experimental study. International Journal of Psychiatry in Medicine, 15(3), pp. 293-8.
Kay SR, Opler LA. L-dopa in the Treatment of Negative Schizophrenic Symptoms: a Single-subject Experimental Study. Int J Psychiatry Med. 1986;15(3):293-8. PubMed PMID: 2866168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - L-dopa in the treatment of negative schizophrenic symptoms: a single-subject experimental study. AU - Kay,S R, AU - Opler,L A, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 293 EP - 8 JF - International journal of psychiatry in medicine JO - Int J Psychiatry Med VL - 15 IS - 3 N2 - Adjunctive Sinemet (L-DOPA plus carbidopa) therapy was assessed for a neuroleptic nonresponsive schizophrenic with a longstanding negative syndrome. A twenty-seven week double-blind placebo-controlled reversal design found significant improvement specifically for negative symptoms while treated with combined haloperidol-Sinemet as compared against haloperidol-placebo. The eight-week adjunctive treatment reversed a worsening trend in attention, abstract thinking, passive withdrawal, psychomotor retardation, and a cluster of seven negative parameters, while positive symptoms were unaffected. This seemed to represent more than simple reversal of drug-induced akinesia and underscores the importance of distinguishing between positive and negative syndromes in psychopharmacological research. SN - 0091-2174 UR - https://www.unboundmedicine.com/medline/citation/2866168/L_dopa_in_the_treatment_of_negative_schizophrenic_symptoms:_a_single_subject_experimental_study_ L2 - http://journals.sagepub.com/doi/full/10.2190/lmel-l5hq-peqv-vycj?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -