Tags

Type your tag names separated by a space and hit enter

Efficacy of Intravenous Ondansetron for Prevention of Postspinal Shivering during Lower Segment Cesarean Section: A Double-Blinded Randomized Trial.
Anesth Essays Res 2017 Apr-Jun; 11(2):508-513AE

Abstract

BACKGROUND AND AIMS

Elective lower segment cesarean section under spinal anesthesia is frequently associated with shivering. Ondansetron has been shown to be effective for postspinal shivering. In the present study, we compare the efficacy of ondansetron to prevent postspinal shivering in parturients undergoing cesarean delivery under spinal anesthesia.

MATERIALS AND METHODS

A total of eighty full-term parturients scheduled for elective lower segment cesarean section under spinal anesthesia were randomly allocated into two groups. Group O received 8 mg/4 ml ondansetron, and Group S received 4 ml normal saline intravenously immediately before induction of spinal anesthesia. The level of sensory block, core body temperature, shivering score, and presence or absence of nausea and vomiting during the perioperative period, 1st and 5th min neonates Apgar scores were recorded. The data analysis was carried out with Z-test and Chi-square test.

RESULTS

Ten percent (4/40) of patients in Group O and 42.5% (17/40) of patients in Group S had Grade III shivering during the perioperative period and that was treated with intravenous injection tramadol (P = 0.001). Two patients (5%) in ondansetron and 19 patients (47.5%) in control group had nausea and vomiting (P < 0.001) and was treated with intravenous 10 mg metoclopramide. 1st and 5th min Apgar scores of neonates were not statistically different in the groups.

CONCLUSIONS

Ondansetron is an effective way to prevent shivering, nausea and vomiting during lower segment cesarean section under spinal anesthesia with no effect on Apgar score.

Authors+Show Affiliations

Department of Anaesthesiology and Critical Care, RIMS, Kadapa, Andhra Pradesh, India.Department of Anaesthesiology and Critical Care, RIMS, Kadapa, Andhra Pradesh, India.Department of Anaesthesiology and Critical Care, RIMS, Kadapa, Andhra Pradesh, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28663651

Citation

Nallam, Srinivasa Rao, et al. "Efficacy of Intravenous Ondansetron for Prevention of Postspinal Shivering During Lower Segment Cesarean Section: a Double-Blinded Randomized Trial." Anesthesia, Essays and Researches, vol. 11, no. 2, 2017, pp. 508-513.
Nallam SR, Cherukuru K, Sateesh G. Efficacy of Intravenous Ondansetron for Prevention of Postspinal Shivering during Lower Segment Cesarean Section: A Double-Blinded Randomized Trial. Anesth Essays Res. 2017;11(2):508-513.
Nallam, S. R., Cherukuru, K., & Sateesh, G. (2017). Efficacy of Intravenous Ondansetron for Prevention of Postspinal Shivering during Lower Segment Cesarean Section: A Double-Blinded Randomized Trial. Anesthesia, Essays and Researches, 11(2), pp. 508-513. doi:10.4103/aer.AER_26_17.
Nallam SR, Cherukuru K, Sateesh G. Efficacy of Intravenous Ondansetron for Prevention of Postspinal Shivering During Lower Segment Cesarean Section: a Double-Blinded Randomized Trial. Anesth Essays Res. 2017;11(2):508-513. PubMed PMID: 28663651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Intravenous Ondansetron for Prevention of Postspinal Shivering during Lower Segment Cesarean Section: A Double-Blinded Randomized Trial. AU - Nallam,Srinivasa Rao, AU - Cherukuru,Kavya, AU - Sateesh,Gokul, PY - 2017/7/1/entrez PY - 2017/7/1/pubmed PY - 2017/7/1/medline KW - Anesthesia KW - cesarean section KW - female KW - ondansetron KW - pregnancy KW - shivering KW - spinal SP - 508 EP - 513 JF - Anesthesia, essays and researches JO - Anesth Essays Res VL - 11 IS - 2 N2 - BACKGROUND AND AIMS: Elective lower segment cesarean section under spinal anesthesia is frequently associated with shivering. Ondansetron has been shown to be effective for postspinal shivering. In the present study, we compare the efficacy of ondansetron to prevent postspinal shivering in parturients undergoing cesarean delivery under spinal anesthesia. MATERIALS AND METHODS: A total of eighty full-term parturients scheduled for elective lower segment cesarean section under spinal anesthesia were randomly allocated into two groups. Group O received 8 mg/4 ml ondansetron, and Group S received 4 ml normal saline intravenously immediately before induction of spinal anesthesia. The level of sensory block, core body temperature, shivering score, and presence or absence of nausea and vomiting during the perioperative period, 1st and 5th min neonates Apgar scores were recorded. The data analysis was carried out with Z-test and Chi-square test. RESULTS: Ten percent (4/40) of patients in Group O and 42.5% (17/40) of patients in Group S had Grade III shivering during the perioperative period and that was treated with intravenous injection tramadol (P = 0.001). Two patients (5%) in ondansetron and 19 patients (47.5%) in control group had nausea and vomiting (P < 0.001) and was treated with intravenous 10 mg metoclopramide. 1st and 5th min Apgar scores of neonates were not statistically different in the groups. CONCLUSIONS: Ondansetron is an effective way to prevent shivering, nausea and vomiting during lower segment cesarean section under spinal anesthesia with no effect on Apgar score. SN - 0259-1162 UR - https://www.unboundmedicine.com/medline/citation/28663651/Efficacy_of_Intravenous_Ondansetron_for_Prevention_of_Postspinal_Shivering_during_Lower_Segment_Cesarean_Section:_A_Double_Blinded_Randomized_Trial_ L2 - http://www.aeronline.org/article.asp?issn=0259-1162;year=2017;volume=11;issue=2;spage=508;epage=513;aulast=Nallam;type=2 DB - PRIME DP - Unbound Medicine ER -