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James Parkinson's Chimera: syndrome or disease?
J R Coll Physicians Edinb. 2017 Jun; 47(2):190-195.JR

Abstract

It is 200 years since James Parkinson published An Essay on the Shaking Palsy. While his monograph continues to be acclaimed for its precedence and clarity of description, what is often overlooked is the originality of Parkinson's ideas. Here we show that he appreciated the weakness of the systematic 18th century nosologies, which presupposed that medical species, the building blocks of these Linnaean taxonomic schemes, were as distinct as plant and animal species; and that Parkinson made a conceptual leap about combinations of clinical phenomena in recurring patterns, now recognised to be one of the germs of neurological thinking about syndromes. The Essay's written style underpins another aspect of significance to contemporary neurological practice - an inherent intellectual humility. In this commemorative year we locate the continuing importance of the related notions of syndrome and disease in successive frameworks of knowledge about the shaking palsy. Syndrome and disease are interpreted as dual character concepts, one clinically-based and the other restricted to pathophysiological causation. They both remain fundamental to understanding Parkinson's syndrome-disease today.

Authors+Show Affiliations

PA Kempster, Neurosciences Department, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3121, Australia. Email: peter.kempster@monashhealth.org.No affiliation info availableNo affiliation info available

Pub Type(s)

Biography
Historical Article
Journal Article

Language

eng

PubMed ID

28675197

Citation

Kempster, P A., et al. "James Parkinson's Chimera: Syndrome or Disease?" The Journal of the Royal College of Physicians of Edinburgh, vol. 47, no. 2, 2017, pp. 190-195.
Kempster PA, Hurwitz B, Lees AJ. James Parkinson's Chimera: syndrome or disease? J R Coll Physicians Edinb. 2017;47(2):190-195.
Kempster, P. A., Hurwitz, B., & Lees, A. J. (2017). James Parkinson's Chimera: syndrome or disease? The Journal of the Royal College of Physicians of Edinburgh, 47(2), 190-195. https://doi.org/10.4997/JRCPE.2017.220
Kempster PA, Hurwitz B, Lees AJ. James Parkinson's Chimera: Syndrome or Disease. J R Coll Physicians Edinb. 2017;47(2):190-195. PubMed PMID: 28675197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - James Parkinson's Chimera: syndrome or disease? AU - Kempster,P A, AU - Hurwitz,B, AU - Lees,A J, PY - 2017/7/5/entrez PY - 2017/7/5/pubmed PY - 2018/5/22/medline KW - James Parkinson KW - Parkinson’s disease KW - aortic valve replacement KW - nosology KW - syndrome SP - 190 EP - 195 JF - The journal of the Royal College of Physicians of Edinburgh JO - J R Coll Physicians Edinb VL - 47 IS - 2 N2 - It is 200 years since James Parkinson published An Essay on the Shaking Palsy. While his monograph continues to be acclaimed for its precedence and clarity of description, what is often overlooked is the originality of Parkinson's ideas. Here we show that he appreciated the weakness of the systematic 18th century nosologies, which presupposed that medical species, the building blocks of these Linnaean taxonomic schemes, were as distinct as plant and animal species; and that Parkinson made a conceptual leap about combinations of clinical phenomena in recurring patterns, now recognised to be one of the germs of neurological thinking about syndromes. The Essay's written style underpins another aspect of significance to contemporary neurological practice - an inherent intellectual humility. In this commemorative year we locate the continuing importance of the related notions of syndrome and disease in successive frameworks of knowledge about the shaking palsy. Syndrome and disease are interpreted as dual character concepts, one clinically-based and the other restricted to pathophysiological causation. They both remain fundamental to understanding Parkinson's syndrome-disease today. SN - 2042-8189 UR - https://www.unboundmedicine.com/medline/citation/28675197/James_Parkinson's_Chimera:_syndrome_or_disease L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -