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Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway.
Oncol Rep. 2017 Aug; 38(2):1312-1320.OR

Abstract

Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found that matrine significantly inhibited cervical cancer cell growth by inducing apoptosis, and suppressed the invasion and migration ability of cervical cancer cells in vitro in a concentration-dependent manner. Mechanistically, we found that matrine decreased the expression and activity of the extracellular matrix factors, matrix metalloproteinases-2 (MMP-2) and MMP-9 via the suppression of p38 signaling pathway. In addition, when cervical cancer cells were grown as xenografts in nude mice, intraperitoneal (i.p.) injection of matrine induced a significant dose-dependent decrease in tumor growth. Taken together, these findings suggest that a potential mechanism by which matrine inhibits the growth and metastasis of cervical cancer through downregulating the p38 signaling pathway.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28677790

Citation

Wu, Xiaoling, et al. "Matrine Inhibits the Metastatic Properties of Human Cervical Cancer Cells Via Downregulating the P38 Signaling Pathway." Oncology Reports, vol. 38, no. 2, 2017, pp. 1312-1320.
Wu X, Zhou J, Cai D, et al. Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway. Oncol Rep. 2017;38(2):1312-1320.
Wu, X., Zhou, J., Cai, D., & Li, M. (2017). Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway. Oncology Reports, 38(2), 1312-1320. https://doi.org/10.3892/or.2017.5787
Wu X, et al. Matrine Inhibits the Metastatic Properties of Human Cervical Cancer Cells Via Downregulating the P38 Signaling Pathway. Oncol Rep. 2017;38(2):1312-1320. PubMed PMID: 28677790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway. AU - Wu,Xiaoling, AU - Zhou,Jie, AU - Cai,Dongge, AU - Li,Mu, Y1 - 2017/07/03/ PY - 2017/02/03/received PY - 2017/06/26/accepted PY - 2017/7/6/pubmed PY - 2018/7/24/medline PY - 2017/7/6/entrez SP - 1312 EP - 1320 JF - Oncology reports JO - Oncol Rep VL - 38 IS - 2 N2 - Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found that matrine significantly inhibited cervical cancer cell growth by inducing apoptosis, and suppressed the invasion and migration ability of cervical cancer cells in vitro in a concentration-dependent manner. Mechanistically, we found that matrine decreased the expression and activity of the extracellular matrix factors, matrix metalloproteinases-2 (MMP-2) and MMP-9 via the suppression of p38 signaling pathway. In addition, when cervical cancer cells were grown as xenografts in nude mice, intraperitoneal (i.p.) injection of matrine induced a significant dose-dependent decrease in tumor growth. Taken together, these findings suggest that a potential mechanism by which matrine inhibits the growth and metastasis of cervical cancer through downregulating the p38 signaling pathway. SN - 1791-2431 UR - https://www.unboundmedicine.com/medline/citation/28677790/Matrine_inhibits_the_metastatic_properties_of_human_cervical_cancer_cells_via_downregulating_the_p38_signaling_pathway_ L2 - http://www.spandidos-publications.com/or/38/2/1312 DB - PRIME DP - Unbound Medicine ER -