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Chronic exposure to a glyphosate-based herbicide makes toad larvae more toxic.
Proc Biol Sci. 2017 Jul 12; 284(1858)PB

Abstract

Chemical pollutants can exert various sublethal effects on wildlife, leading to complex fitness consequences. Many animals use defensive chemicals as protection from predators and diseases, yet the effects of chemical contaminants on this important fitness component are poorly known. Understanding such effects is especially relevant for amphibians, the globally most threatened group of vertebrates, because they are particularly vulnerable to chemical pollution. We conducted two experiments to investigate how exposure to glyphosate-based herbicides, the most widespread agrochemicals worldwide, affects the production of bufadienolides, the main compounds of chemical defence in common toads (Bufo bufo). In both experiments, herbicide exposure increased the amount of bufadienolides in toad tadpoles. In the laboratory, individuals exposed to 4 mg a.e./L glyphosate throughout their larval development had higher bufadienolide content at metamorphosis than non-exposed tadpoles, whereas exposure for 9 days to the same concentration or to 2 mg a.e./L throughout larval development or for 9 days had no detectable effect. In outdoor mesocosms, tadpoles from 16 populations exhibited elevated bufadienolide content after three-weeks exposure to both concentrations of the herbicide. These results show that pesticide exposure can have unexpected effects on non-target organisms, with potential consequences for the conservation management of toxin-producing species and their predators.

Authors+Show Affiliations

Lendület Evolutionary Ecology Research Group, Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Herman Ottó út 15, Budapest 1022, Hungary bokony.veronika@agrar.mta.hu.Lendület Evolutionary Ecology Research Group, Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Herman Ottó út 15, Budapest 1022, Hungary.Department of Pathophysiology, Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Herman Ottó út 15, Budapest 1022, Hungary.Department of Pathophysiology, Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Herman Ottó út 15, Budapest 1022, Hungary.Lendület Evolutionary Ecology Research Group, Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Herman Ottó út 15, Budapest 1022, Hungary.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28679726

Citation

Bókony, Veronika, et al. "Chronic Exposure to a Glyphosate-based Herbicide Makes Toad Larvae More Toxic." Proceedings. Biological Sciences, vol. 284, no. 1858, 2017.
Bókony V, Mikó Z, Móricz ÁM, et al. Chronic exposure to a glyphosate-based herbicide makes toad larvae more toxic. Proc Biol Sci. 2017;284(1858).
Bókony, V., Mikó, Z., Móricz, Á. M., Krüzselyi, D., & Hettyey, A. (2017). Chronic exposure to a glyphosate-based herbicide makes toad larvae more toxic. Proceedings. Biological Sciences, 284(1858). https://doi.org/10.1098/rspb.2017.0493
Bókony V, et al. Chronic Exposure to a Glyphosate-based Herbicide Makes Toad Larvae More Toxic. Proc Biol Sci. 2017 Jul 12;284(1858) PubMed PMID: 28679726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic exposure to a glyphosate-based herbicide makes toad larvae more toxic. AU - Bókony,Veronika, AU - Mikó,Zsanett, AU - Móricz,Ágnes M, AU - Krüzselyi,Dániel, AU - Hettyey,Attila, PY - 2017/03/08/received PY - 2017/06/01/accepted PY - 2017/7/7/entrez PY - 2017/7/7/pubmed PY - 2018/2/2/medline KW - bufadienolides KW - chemical defence KW - ecotoxicology KW - pesticides KW - phenotypic plasticity JF - Proceedings. Biological sciences JO - Proc Biol Sci VL - 284 IS - 1858 N2 - Chemical pollutants can exert various sublethal effects on wildlife, leading to complex fitness consequences. Many animals use defensive chemicals as protection from predators and diseases, yet the effects of chemical contaminants on this important fitness component are poorly known. Understanding such effects is especially relevant for amphibians, the globally most threatened group of vertebrates, because they are particularly vulnerable to chemical pollution. We conducted two experiments to investigate how exposure to glyphosate-based herbicides, the most widespread agrochemicals worldwide, affects the production of bufadienolides, the main compounds of chemical defence in common toads (Bufo bufo). In both experiments, herbicide exposure increased the amount of bufadienolides in toad tadpoles. In the laboratory, individuals exposed to 4 mg a.e./L glyphosate throughout their larval development had higher bufadienolide content at metamorphosis than non-exposed tadpoles, whereas exposure for 9 days to the same concentration or to 2 mg a.e./L throughout larval development or for 9 days had no detectable effect. In outdoor mesocosms, tadpoles from 16 populations exhibited elevated bufadienolide content after three-weeks exposure to both concentrations of the herbicide. These results show that pesticide exposure can have unexpected effects on non-target organisms, with potential consequences for the conservation management of toxin-producing species and their predators. SN - 1471-2954 UR - https://www.unboundmedicine.com/medline/citation/28679726/<br />Chronic_exposure_to_a_glyphosate-based_herbicide_makes_toad_larvae_more_toxic.2017 L2 - https://royalsocietypublishing.org/doi/10.1098/rspb.2017.0493?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -