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A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients.
Prog Orthod. 2017 Dec; 18(1):20.PO

Abstract

BACKGROUND

The aim of this study was to investigate the prevalence of tooth agenesis, microdontia, and tooth malformation among non-syndromic oral cleft patients and their potential association with cleft type and gender.

METHODS

Intraoral records and radiographs of 154 patients (97 males and 57 females) were examined. The variables assessed were tooth agenesis, microdontia, dental malformations, and cleft types. The statistics included chi-square and Fisher's exact tests as well as logistic regression to assess any mutual effects of gender and cleft type on the dental variables.

RESULTS

Tooth agenesis occurred in 50% of the sample and microdontia in 18%. Non-statistically significant odds ratios for the association of gender and cleft type with tooth agenesis were obtained. Tooth agenesis was substantially higher at the unilateral right CL + P and the bilateral CL + P in quadrant 1 and at the unilateral left CL + P and bilateral CL + P in quadrant 2. It was also higher, at the isolated cleft palate (CP) in quadrants 3 and 4. These results were attributed to teeth 22 (31.8%) and 12 (21.6%) in the maxilla and to teeth 35 (6.1%) and 45 (5.4%) in the mandible. In unilateral CL + P patients, the cleft quadrant that presented tooth agenesis was associated with the side of the cleft.

CONCLUSIONS

Interdisciplinary treatment of the oral cleft patients should take into consideration the high prevalence of tooth agenesis and their association with the different cleft types. The most frequently affected teeth by cleft are by far the upper lateral incisors. Results indicate that tooth agenesis appears to be a genetically controlled anomaly related to the orofacial cleft development through various genetic links and not caused by the cleft disruptive process.

Authors+Show Affiliations

Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon st, 115 26, Athens, Greece. dikons@dent.uoa.gr. Clinic of Orthodontics and Pediatric Dentistry, University of Zurich, Zurich, Switzerland. dikons@dent.uoa.gr.Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon st, 115 26, Athens, Greece.Center for Advanced Dental Education, Department of Orthodontics, Saint Louis University, Saint Louis, MO, USA.Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon st, 115 26, Athens, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28681357

Citation

Konstantonis, Dimitrios, et al. "A Cross-sectional Analysis of the Prevalence of Tooth Agenesis and Structural Dental Anomalies in Association With Cleft Type in Non-syndromic Oral Cleft Patients." Progress in Orthodontics, vol. 18, no. 1, 2017, p. 20.
Konstantonis D, Alexandropoulos A, Konstantoni N, et al. A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients. Prog Orthod. 2017;18(1):20.
Konstantonis, D., Alexandropoulos, A., Konstantoni, N., & Nassika, M. (2017). A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients. Progress in Orthodontics, 18(1), 20. https://doi.org/10.1186/s40510-017-0169-x
Konstantonis D, et al. A Cross-sectional Analysis of the Prevalence of Tooth Agenesis and Structural Dental Anomalies in Association With Cleft Type in Non-syndromic Oral Cleft Patients. Prog Orthod. 2017;18(1):20. PubMed PMID: 28681357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients. AU - Konstantonis,Dimitrios, AU - Alexandropoulos,Alexandros, AU - Konstantoni,Nikoleta, AU - Nassika,Maria, Y1 - 2017/06/25/ PY - 2016/12/28/received PY - 2017/05/15/accepted PY - 2017/7/7/entrez PY - 2017/7/7/pubmed PY - 2018/5/16/medline KW - Cleft lip and palate KW - Dental anomalies KW - Microdontia KW - Tooth agenesis SP - 20 EP - 20 JF - Progress in orthodontics JO - Prog Orthod VL - 18 IS - 1 N2 - BACKGROUND: The aim of this study was to investigate the prevalence of tooth agenesis, microdontia, and tooth malformation among non-syndromic oral cleft patients and their potential association with cleft type and gender. METHODS: Intraoral records and radiographs of 154 patients (97 males and 57 females) were examined. The variables assessed were tooth agenesis, microdontia, dental malformations, and cleft types. The statistics included chi-square and Fisher's exact tests as well as logistic regression to assess any mutual effects of gender and cleft type on the dental variables. RESULTS: Tooth agenesis occurred in 50% of the sample and microdontia in 18%. Non-statistically significant odds ratios for the association of gender and cleft type with tooth agenesis were obtained. Tooth agenesis was substantially higher at the unilateral right CL + P and the bilateral CL + P in quadrant 1 and at the unilateral left CL + P and bilateral CL + P in quadrant 2. It was also higher, at the isolated cleft palate (CP) in quadrants 3 and 4. These results were attributed to teeth 22 (31.8%) and 12 (21.6%) in the maxilla and to teeth 35 (6.1%) and 45 (5.4%) in the mandible. In unilateral CL + P patients, the cleft quadrant that presented tooth agenesis was associated with the side of the cleft. CONCLUSIONS: Interdisciplinary treatment of the oral cleft patients should take into consideration the high prevalence of tooth agenesis and their association with the different cleft types. The most frequently affected teeth by cleft are by far the upper lateral incisors. Results indicate that tooth agenesis appears to be a genetically controlled anomaly related to the orofacial cleft development through various genetic links and not caused by the cleft disruptive process. SN - 2196-1042 UR - https://www.unboundmedicine.com/medline/citation/28681357/A_cross_sectional_analysis_of_the_prevalence_of_tooth_agenesis_and_structural_dental_anomalies_in_association_with_cleft_type_in_non_syndromic_oral_cleft_patients_ L2 - https://dx.doi.org/10.1186/s40510-017-0169-x DB - PRIME DP - Unbound Medicine ER -