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The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism.
Life Sci 2017; 183:110-115LS

Abstract

Cancer cells are well documented to reprogram their metabolism in order to support the maintenance and reproduction. 3-oxoacid CoA-transferase 1 (OXCT1) is a key enzyme in ketone body metabolism that catalyzes the first and rate-determining step of ketolysis. The product of OXCT1 converts to acetyl-CoA and finally fed into the tricarboxylic acid cycle for oxidation and ATP production. However, little is known of its regulation right now. Recently, some studies suggested that OXCT1 participates in tumorigenesis and signaling in cancer cells. Furthermore, our recent work showed that a marked elevation of OXCT1 expression in different categories of cancer cells. Here we review the metabolic functions of OXCT1 and its surprising roles in supporting the biological hallmarks of malignancy. We also review recent efforts in exploring the mechanism responsible for the tumor promoting effect of OXCT1 and suggest a novel therapeutic target for cancer therapy.

Authors+Show Affiliations

School of Life Sciences, Nanchang University, Nanchang, Jiangxi, PR China; Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, PR China.Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, PR China. Electronic address: xiecaifeng@ncu.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28684065

Citation

Zhang, Song, and Caifeng Xie. "The Role of OXCT1 in the Pathogenesis of Cancer as a Rate-limiting Enzyme of Ketone Body Metabolism." Life Sciences, vol. 183, 2017, pp. 110-115.
Zhang S, Xie C. The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism. Life Sci. 2017;183:110-115.
Zhang, S., & Xie, C. (2017). The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism. Life Sciences, 183, pp. 110-115. doi:10.1016/j.lfs.2017.07.003.
Zhang S, Xie C. The Role of OXCT1 in the Pathogenesis of Cancer as a Rate-limiting Enzyme of Ketone Body Metabolism. Life Sci. 2017 Aug 15;183:110-115. PubMed PMID: 28684065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism. AU - Zhang,Song, AU - Xie,Caifeng, Y1 - 2017/07/04/ PY - 2017/04/07/received PY - 2017/06/23/revised PY - 2017/07/03/accepted PY - 2017/7/8/pubmed PY - 2017/8/9/medline PY - 2017/7/8/entrez KW - Cancer KW - Ketone body KW - OXCT1 KW - Pathogenesis SP - 110 EP - 115 JF - Life sciences JO - Life Sci. VL - 183 N2 - Cancer cells are well documented to reprogram their metabolism in order to support the maintenance and reproduction. 3-oxoacid CoA-transferase 1 (OXCT1) is a key enzyme in ketone body metabolism that catalyzes the first and rate-determining step of ketolysis. The product of OXCT1 converts to acetyl-CoA and finally fed into the tricarboxylic acid cycle for oxidation and ATP production. However, little is known of its regulation right now. Recently, some studies suggested that OXCT1 participates in tumorigenesis and signaling in cancer cells. Furthermore, our recent work showed that a marked elevation of OXCT1 expression in different categories of cancer cells. Here we review the metabolic functions of OXCT1 and its surprising roles in supporting the biological hallmarks of malignancy. We also review recent efforts in exploring the mechanism responsible for the tumor promoting effect of OXCT1 and suggest a novel therapeutic target for cancer therapy. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/28684065/The_role_of_OXCT1_in_the_pathogenesis_of_cancer_as_a_rate-limiting_enzyme_of_ketone_body_metabolism L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(17)30323-5 DB - PRIME DP - Unbound Medicine ER -