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Compatibility of fosfomycin with different commercial peritoneal dialysis solutions.
Eur J Clin Microbiol Infect Dis. 2017 Nov; 36(11):2237-2242.EJ

Abstract

For treatment of peritoneal dialysis-related peritonitis, intraperitoneal administration of antibiotics remains the preferable route. For home-based therapy, patients are commonly supplied with peritoneal dialysis fluids already containing antimicrobial agents. The present study set out to investigate the compatibility of fosfomycin with different peritoneal dialysis fluids, namely, Extraneal®, Nutrineal®, Physioneal® 1.36% and Physioneal® 2.27%, under varying storage conditions. The peritoneal dialysis fluid bags including 4 g fosfomycin were stored over 14 days at refrigeration temperature (6°C) and room temperature (25°C) and over 24 h at body temperature (37°C). Drug concentrations over time were determined by using high-performance liquid chromatography coupled to a mass spectrometer. In addition, drug activity was assessed by a disk diffusion method, diluent stability by visual inspection and drug adsorption by comparison of the measured and calculated concentrations. Blank peritoneal dialysis fluids and deionized water were used as comparator solutions. Fosfomycin was stable in all peritoneal dialysis fluids and at each storage condition investigated over the whole study period. The remaining drug concentrations ranged between 94% and 104% of the respective initial concentrations. No significant drug adsorption was observed for any peritoneal dialysis fluid at any storage condition. No relevant reduction of antimicrobial activity was observed. Fosfomycin is compatible with Extraneal®, Nutrineal® and Physioneal® for up to two weeks at refrigeration or room temperature and may be used for home-based therapy. No dose adjustment is needed due to adsorption or degradation.

Authors+Show Affiliations

Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Vienna, Austria.Department of Pharmacognosy, University of Vienna, Vienna, Austria.Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Vienna, Austria.Department of Internal Medicine I, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, St. Poelten, Austria.Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria.Department of Internal Medicine I, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, St. Poelten, Austria.Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Vienna, Austria. heinz.burgmann@meduniwien.ac.at.Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Vienna, Austria. Military Medical Cluster East, Austrian Armed Forces, Vienna, Austria.Department of Pharmacognosy, University of Vienna, Vienna, Austria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28685187

Citation

Kussmann, M, et al. "Compatibility of Fosfomycin With Different Commercial Peritoneal Dialysis Solutions." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, vol. 36, no. 11, 2017, pp. 2237-2242.
Kussmann M, Baumann A, Hauer S, et al. Compatibility of fosfomycin with different commercial peritoneal dialysis solutions. Eur J Clin Microbiol Infect Dis. 2017;36(11):2237-2242.
Kussmann, M., Baumann, A., Hauer, S., Pichler, P., Zeitlinger, M., Wiesholzer, M., Burgmann, H., Poeppl, W., & Reznicek, G. (2017). Compatibility of fosfomycin with different commercial peritoneal dialysis solutions. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 36(11), 2237-2242. https://doi.org/10.1007/s10096-017-3051-3
Kussmann M, et al. Compatibility of Fosfomycin With Different Commercial Peritoneal Dialysis Solutions. Eur J Clin Microbiol Infect Dis. 2017;36(11):2237-2242. PubMed PMID: 28685187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compatibility of fosfomycin with different commercial peritoneal dialysis solutions. AU - Kussmann,M, AU - Baumann,A, AU - Hauer,S, AU - Pichler,P, AU - Zeitlinger,M, AU - Wiesholzer,M, AU - Burgmann,H, AU - Poeppl,W, AU - Reznicek,G, Y1 - 2017/07/06/ PY - 2017/05/13/received PY - 2017/06/19/accepted PY - 2017/7/8/pubmed PY - 2018/6/13/medline PY - 2017/7/8/entrez SP - 2237 EP - 2242 JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology JO - Eur J Clin Microbiol Infect Dis VL - 36 IS - 11 N2 - For treatment of peritoneal dialysis-related peritonitis, intraperitoneal administration of antibiotics remains the preferable route. For home-based therapy, patients are commonly supplied with peritoneal dialysis fluids already containing antimicrobial agents. The present study set out to investigate the compatibility of fosfomycin with different peritoneal dialysis fluids, namely, Extraneal®, Nutrineal®, Physioneal® 1.36% and Physioneal® 2.27%, under varying storage conditions. The peritoneal dialysis fluid bags including 4 g fosfomycin were stored over 14 days at refrigeration temperature (6°C) and room temperature (25°C) and over 24 h at body temperature (37°C). Drug concentrations over time were determined by using high-performance liquid chromatography coupled to a mass spectrometer. In addition, drug activity was assessed by a disk diffusion method, diluent stability by visual inspection and drug adsorption by comparison of the measured and calculated concentrations. Blank peritoneal dialysis fluids and deionized water were used as comparator solutions. Fosfomycin was stable in all peritoneal dialysis fluids and at each storage condition investigated over the whole study period. The remaining drug concentrations ranged between 94% and 104% of the respective initial concentrations. No significant drug adsorption was observed for any peritoneal dialysis fluid at any storage condition. No relevant reduction of antimicrobial activity was observed. Fosfomycin is compatible with Extraneal®, Nutrineal® and Physioneal® for up to two weeks at refrigeration or room temperature and may be used for home-based therapy. No dose adjustment is needed due to adsorption or degradation. SN - 1435-4373 UR - https://www.unboundmedicine.com/medline/citation/28685187/Compatibility_of_fosfomycin_with_different_commercial_peritoneal_dialysis_solutions_ L2 - https://dx.doi.org/10.1007/s10096-017-3051-3 DB - PRIME DP - Unbound Medicine ER -