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Prevalence of and risk factors for diabetic ketosis in Chinese diabetic patients with random blood glucose levels >13.9 mmol/L: Results from the CHina study in prEvalence of diabetiC Ketosis (CHECK) study.
J Diabetes. 2018 Mar; 10(3):249-255.JD

Abstract

BACKGROUND

The aim of the present study was to investigate the prevalence of diabetic ketosis (DK) and its risk factors in Chinese diabetes patients with severe hyperglycemia.

METHODS

The present multicenter cross-sectional study was performed on patients aged >16 years with diabetes mellitus (DM) and random blood glucose levels >13.9 mmol/L (>250 mg/dL). Blood ketones (β-hydroxybutyric acid) and urinary ketones (acetoacetic acid) were measured and information on patient demographic and clinical characteristics was collected.

RESULTS

Of 1235 patients enrolled in the study (93 with type 1 DM [T1DM]), 1142 with type 2 DM [T2DM]), 242 (19.6%) had DK (blood ketone levels ≥0.6 mmol/L). Proportionately, DK was more frequent and more severe in patients with T1DM than T2DM (55.9% vs 16.6%, respectively), but in absolute terms occurred in more patients with T2DM (52 vs 190). In patients with blood ketone levels ≥3 mmol/L, the cut-off point of blood glucose levels was 19.05 mmol/L. Risk factors significantly associated with higher blood ketone levels in T2DM included younger age, a shorter duration of diabetes, and not using antidiabetic medication within 12 months prior to the hyperglycemic episode.

CONCLUSIONS

The prevalence of DK is lower in patients with T2DM than T1DM, but the number of patients with DK is higher for those with T2DM because of more T2DM patients in China. Patients with T2DM who have a younger age, shorter duration of diabetes, and a lack of antidiabetic treatment will suffer from DK more often than older patients with longer T2DM duration and receiving antidiabetic treatment.

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Authors+Show Affiliations

Gao L
Department of Endocrine and Metabolic Diseases, Peking University People's Hospital, Beijing, China.
Li Y
Department of Endocrine, Beijing Pinggu District Hospital, Beijing, China.
Fei D
Department of Endocrine and Metabolic Disease, Zaozhuang City Hospital, Shandong, China.
Ma L
Department of Endocrine, South District of Guanganmen Hospital of Chinese Academy of Medical Sciences, Beijing, China.
Chen S
Department of Endocrine, People's Hospital of Hebei Province, Hebei, China.
Feng B
Department of Endocrine, Xinhua Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
Su Q
Department of Endocrine, Tongji University Oriental Hospital, Shanghai, China.
Ji L
Department of Endocrine and Metabolic Diseases, Peking University People's Hospital, Beijing, China.

MeSH

AdultBiomarkersBlood GlucoseChinaCross-Sectional StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic KetoacidosisFemaleFollow-Up StudiesGlycated Hemoglobin AHumansMaleMiddle AgedPrevalencePrognosisRisk Factors

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28685968

Citation

Gao, Leili, et al. "Prevalence of and Risk Factors for Diabetic Ketosis in Chinese Diabetic Patients With Random Blood Glucose Levels >13.9 mmol/L: Results From the CHina Study in prEvalence of diabetiC Ketosis (CHECK) Study." Journal of Diabetes, vol. 10, no. 3, 2018, pp. 249-255.
Gao L, Li Y, Fei D, et al. Prevalence of and risk factors for diabetic ketosis in Chinese diabetic patients with random blood glucose levels >13.9 mmol/L: Results from the CHina study in prEvalence of diabetiC Ketosis (CHECK) study. J Diabetes. 2018;10(3):249-255.
Gao, L., Li, Y., Fei, D., Ma, L., Chen, S., Feng, B., Su, Q., & Ji, L. (2018). Prevalence of and risk factors for diabetic ketosis in Chinese diabetic patients with random blood glucose levels >13.9 mmol/L: Results from the CHina study in prEvalence of diabetiC Ketosis (CHECK) study. Journal of Diabetes, 10(3), 249-255. https://doi.org/10.1111/1753-0407.12582
Gao L, et al. Prevalence of and Risk Factors for Diabetic Ketosis in Chinese Diabetic Patients With Random Blood Glucose Levels >13.9 mmol/L: Results From the CHina Study in prEvalence of diabetiC Ketosis (CHECK) Study. J Diabetes. 2018;10(3):249-255. PubMed PMID: 28685968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of and risk factors for diabetic ketosis in Chinese diabetic patients with random blood glucose levels >13.9 mmol/L: Results from the CHina study in prEvalence of diabetiC Ketosis (CHECK) study. AU - Gao,Leili, AU - Li,Yufeng, AU - Fei,Dadong, AU - Ma,Li, AU - Chen,Shuchun, AU - Feng,Bo, AU - Su,Qing, AU - Ji,Linong, Y1 - 2017/08/25/ PY - 2017/06/13/received PY - 2017/06/29/accepted PY - 2017/7/8/pubmed PY - 2018/8/18/medline PY - 2017/7/8/entrez KW - China KW - diabetes mellitus KW - diabetic ketosis KW - prevalence KW - risk factors KW - 中国 KW - 危险因素 KW - 患病率 KW - 糖尿病 KW - 糖尿病酮症 SP - 249 EP - 255 JF - Journal of diabetes JO - J Diabetes VL - 10 IS - 3 N2 - BACKGROUND: The aim of the present study was to investigate the prevalence of diabetic ketosis (DK) and its risk factors in Chinese diabetes patients with severe hyperglycemia. METHODS: The present multicenter cross-sectional study was performed on patients aged >16 years with diabetes mellitus (DM) and random blood glucose levels >13.9 mmol/L (>250 mg/dL). Blood ketones (β-hydroxybutyric acid) and urinary ketones (acetoacetic acid) were measured and information on patient demographic and clinical characteristics was collected. RESULTS: Of 1235 patients enrolled in the study (93 with type 1 DM [T1DM]), 1142 with type 2 DM [T2DM]), 242 (19.6%) had DK (blood ketone levels ≥0.6 mmol/L). Proportionately, DK was more frequent and more severe in patients with T1DM than T2DM (55.9% vs 16.6%, respectively), but in absolute terms occurred in more patients with T2DM (52 vs 190). In patients with blood ketone levels ≥3 mmol/L, the cut-off point of blood glucose levels was 19.05 mmol/L. Risk factors significantly associated with higher blood ketone levels in T2DM included younger age, a shorter duration of diabetes, and not using antidiabetic medication within 12 months prior to the hyperglycemic episode. CONCLUSIONS: The prevalence of DK is lower in patients with T2DM than T1DM, but the number of patients with DK is higher for those with T2DM because of more T2DM patients in China. Patients with T2DM who have a younger age, shorter duration of diabetes, and a lack of antidiabetic treatment will suffer from DK more often than older patients with longer T2DM duration and receiving antidiabetic treatment. SN - 1753-0407 UR - https://www.unboundmedicine.com/medline/citation/28685968/Prevalence_of_and_risk_factors_for_diabetic_ketosis_in_Chinese_diabetic_patients_with_random_blood_glucose_levels_>13_9_mmol/L:_Results_from_the_CHina_study_in_prEvalence_of_diabetiC_Ketosis__CHECK__study_ L2 - https://doi.org/10.1111/1753-0407.12582 DB - PRIME DP - Unbound Medicine ER -