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Gastroprotective actions of Taraxacum coreanum Nakai water extracts in ethanol-induced rat models of acute and chronic gastritis.
J Ethnopharmacol. 2017 Aug 17; 208:84-93.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Taraxacum coreanum Nakai has been traditionally used for treating inflammatory diseases including gastrointestinal diseases.

AIM OF THE STUDY

We studied whether water extracts of Taraxacum coreanum Nakai (TCN) had a protective effect on acute and chronic gastritis induced by ethanol/HCl in an animal model of gastritis and its mechanism was also explored.

MATERIALS AND METHODS

In the acute study, rats were orally administered 0.15g/mL dextrin (normal-control), 0.15g/mL dextrin (control), 0.05g/mL TCN (TCN-L), 0.15g/mL TCN (TCN-H), or 0.01g/mL omeprazole (orally; positive-control), followed by oral administration of 1mL of 60% ethanol plus 150mM HCl (inducer). In the chronic study, rats were administered 10% diluted inducer in drinking water, and 0.6% dextrin, 0.2% or 0.6% TCN, and 0.05% omeprazole were administered in chow for 4 weeks. Acid content, gastric structure, oxidative stress, and markers of inflammation in the stomach tissue were measured at the end of experiment.

RESULTS

Acute and chronic ethanol/HCl administration caused the inner layer of the stomach to redden, hemorrhage, and edema in the control group; TCN-H reduced these symptoms more effectively than did the omeprazole positive-control. Acid production and total acidity in the stomach increased in the control group, which was markedly suppressed by omeprazole. TCN also reduced the acid production and acidity, but not to the same degree as omeprazole. H-E and PAS staining revealed that in the inner layer of the stomach, cellular structure was disrupted, with an increased nuclear size and thickness, disarrangement, and decreased mucin in the control group. TCN prevented the cellular disruption in the inner layer, and TCN-H was more effective than the positive-control. This was associated with oxidative stress and inflammation. TCN dose-dependently reduced the infiltration of mast cells and TNF-α expression in the inner layer of the stomach, and decreased lipid peroxides by increasing superoxide dismutase and glutathione peroxidase expression.

CONCLUSIONS

TCN-H acutely and chronically protected against gastritis and gastric ulcer by reducing oxidative stress and inflammation, not by completely suppressing gastric acid production.

Authors+Show Affiliations

Food Functional Research Division, Korean Food Research Institutes, Sungnam, South Korea. Electronic address: yhj@kfri.re.kr.Food Functional Research Division, Korean Food Research Institutes, Sungnam, South Korea. Electronic address: kmj@kfri.re.kr.Food Functional Research Division, Korean Food Research Institutes, Sungnam, South Korea. Electronic address: dykwon@kfri.re.kr.Dept. of Food and Nutrition, Obesity/Diabetes Center, Hoseo University, Asan, South Korea. Electronic address: rdts6546@naver.com.Dept. of Food and Nutrition, Obesity/Diabetes Center, Hoseo University, Asan, South Korea. Electronic address: roypower003@naver.com.Dept. of Food and Nutrition, Obesity/Diabetes Center, Hoseo University, Asan, South Korea. Electronic address: smpark@hoseo.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28687507

Citation

Yang, Hye Jeong, et al. "Gastroprotective Actions of Taraxacum Coreanum Nakai Water Extracts in Ethanol-induced Rat Models of Acute and Chronic Gastritis." Journal of Ethnopharmacology, vol. 208, 2017, pp. 84-93.
Yang HJ, Kim MJ, Kwon DY, et al. Gastroprotective actions of Taraxacum coreanum Nakai water extracts in ethanol-induced rat models of acute and chronic gastritis. J Ethnopharmacol. 2017;208:84-93.
Yang, H. J., Kim, M. J., Kwon, D. Y., Kang, E. S., Kang, S., & Park, S. (2017). Gastroprotective actions of Taraxacum coreanum Nakai water extracts in ethanol-induced rat models of acute and chronic gastritis. Journal of Ethnopharmacology, 208, 84-93. https://doi.org/10.1016/j.jep.2017.06.045
Yang HJ, et al. Gastroprotective Actions of Taraxacum Coreanum Nakai Water Extracts in Ethanol-induced Rat Models of Acute and Chronic Gastritis. J Ethnopharmacol. 2017 Aug 17;208:84-93. PubMed PMID: 28687507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective actions of Taraxacum coreanum Nakai water extracts in ethanol-induced rat models of acute and chronic gastritis. AU - Yang,Hye Jeong, AU - Kim,Min Jung, AU - Kwon,Dae Young, AU - Kang,Eun Seon, AU - Kang,Suna, AU - Park,Sunmin, Y1 - 2017/07/05/ PY - 2017/04/20/received PY - 2017/06/25/revised PY - 2017/06/27/accepted PY - 2017/7/9/pubmed PY - 2018/2/8/medline PY - 2017/7/9/entrez KW - Gastric ulcer KW - Gastritis KW - Inflammation KW - Oxidative stress KW - Taraxacum coreanum Nakai SP - 84 EP - 93 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 208 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Taraxacum coreanum Nakai has been traditionally used for treating inflammatory diseases including gastrointestinal diseases. AIM OF THE STUDY: We studied whether water extracts of Taraxacum coreanum Nakai (TCN) had a protective effect on acute and chronic gastritis induced by ethanol/HCl in an animal model of gastritis and its mechanism was also explored. MATERIALS AND METHODS: In the acute study, rats were orally administered 0.15g/mL dextrin (normal-control), 0.15g/mL dextrin (control), 0.05g/mL TCN (TCN-L), 0.15g/mL TCN (TCN-H), or 0.01g/mL omeprazole (orally; positive-control), followed by oral administration of 1mL of 60% ethanol plus 150mM HCl (inducer). In the chronic study, rats were administered 10% diluted inducer in drinking water, and 0.6% dextrin, 0.2% or 0.6% TCN, and 0.05% omeprazole were administered in chow for 4 weeks. Acid content, gastric structure, oxidative stress, and markers of inflammation in the stomach tissue were measured at the end of experiment. RESULTS: Acute and chronic ethanol/HCl administration caused the inner layer of the stomach to redden, hemorrhage, and edema in the control group; TCN-H reduced these symptoms more effectively than did the omeprazole positive-control. Acid production and total acidity in the stomach increased in the control group, which was markedly suppressed by omeprazole. TCN also reduced the acid production and acidity, but not to the same degree as omeprazole. H-E and PAS staining revealed that in the inner layer of the stomach, cellular structure was disrupted, with an increased nuclear size and thickness, disarrangement, and decreased mucin in the control group. TCN prevented the cellular disruption in the inner layer, and TCN-H was more effective than the positive-control. This was associated with oxidative stress and inflammation. TCN dose-dependently reduced the infiltration of mast cells and TNF-α expression in the inner layer of the stomach, and decreased lipid peroxides by increasing superoxide dismutase and glutathione peroxidase expression. CONCLUSIONS: TCN-H acutely and chronically protected against gastritis and gastric ulcer by reducing oxidative stress and inflammation, not by completely suppressing gastric acid production. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/28687507/Gastroprotective_actions_of_Taraxacum_coreanum_Nakai_water_extracts_in_ethanol_induced_rat_models_of_acute_and_chronic_gastritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(17)31598-2 DB - PRIME DP - Unbound Medicine ER -