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Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study.
J Neurol Neurophysiol. 2017 Feb; 8(1)JN

Abstract

OBJECTIVE

To explore the gut-brain axis by examining gut hormone levels and cognitive test scores in women with (HIV+) and without (HIV-) HIV infection.

DESIGN/METHODS

Participants included 356 women (248 HIV+, 108 at risk HIV-) in the Brooklyn Women's Interagency HIV Study (WIHS) with measured levels of ghrelin, amylin and gastric inhibitory peptide (GIP), also known as glucose-dependent insulinotropic polypeptide. Cross-sectional analyses using linear regression models estimated the relationship between gut hormones and Trails A, Trails B, Stroop interference time, Stroop word recall, Stroop color naming and reading, and Symbol Digit Modalities Test (SDMT) with consideration for age, HIV infection status, Wide Range Achievement Test score (WRAT), CD4 count, insulin resistance, drug use, and race/ethnicity.

RESULTS

Among women at mid-life with chronic (at least 10 years) HIV infection or among those at risk, ghrelin, amylin and GIP were differentially related to cognitive test performance by cognitive domain. Better performance on cognitive tests was generally associated with higher ghrelin, amylin and GIP levels. However, the strength of association varied, as did significance level by HIV status.

CONCLUSION

Previous analyses in WIHS participants have suggested that higher BMI, waist, and WHR are associated with better cognitive function among women at mid-life with HIV infection. This study indicates that higher gut hormone levels are also associated with better cognition. Gut hormones may provide additional mechanistic insights regarding the association between obesity and Type 2 diabetes and cognition in middle-aged HIV+ and at risk HIV- women. In addition, measuring these hormones longitudinally would add to the understanding of mechanisms of actions of these hormones and their use as potential clinical tools for early identification and intervention on cognitive decline in this vulnerable population.

Authors+Show Affiliations

Department of Medicine, Division of Endocrinology, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.Department of Health Sciences Research, Division of Epidemiology, and Department of Neurology Mayo Clinic, Rochester, MN, USA.Empire Clinical Research Program (ECRIP) fellow, Department of Neurology, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.Blood Systems Research Institute, San Francisco, CA, USA.Department of Medicine/STAR Program, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.Maimonides Hospital, Brooklyn, NY, USA. Department of Obstetrics and Gynecology, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.Department of Neurology, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.Department of Neurology, State University of New York - Downstate Medical Center, Brooklyn, NY, USA. Neuropsychiatric Epidemiology Unit, University of Gothenburg, Gothenburg, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28690913

Citation

McFarlane, Samy I., et al. "Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: the Women's Interagency HIV Study." Journal of Neurology & Neurophysiology, vol. 8, no. 1, 2017.
McFarlane SI, Mielke MM, Uglialoro A, et al. Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study. J Neurol Neurophysiol. 2017;8(1).
McFarlane, S. I., Mielke, M. M., Uglialoro, A., Keating, S. M., Holman, S., Minkoff, H., Crystal, H. A., & Gustafson, D. R. (2017). Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study. Journal of Neurology & Neurophysiology, 8(1). https://doi.org/10.4172/2155-9562.1000413
McFarlane SI, et al. Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: the Women's Interagency HIV Study. J Neurol Neurophysiol. 2017;8(1) PubMed PMID: 28690913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study. AU - McFarlane,Samy I, AU - Mielke,Michelle M, AU - Uglialoro,Anthony, AU - Keating,Sheila M, AU - Holman,Susan, AU - Minkoff,Howard, AU - Crystal,Howard A, AU - Gustafson,Deborah R, Y1 - 2017/02/08/ PY - 2017/7/11/entrez PY - 2017/7/12/pubmed PY - 2017/7/12/medline KW - Amylin KW - Cognition KW - Gastric Inhibitory Peptide (GIP) KW - Ghrelin KW - HIV KW - Middle-aged KW - Obesity KW - Overweight KW - Women JF - Journal of neurology & neurophysiology JO - J Neurol Neurophysiol VL - 8 IS - 1 N2 - OBJECTIVE: To explore the gut-brain axis by examining gut hormone levels and cognitive test scores in women with (HIV+) and without (HIV-) HIV infection. DESIGN/METHODS: Participants included 356 women (248 HIV+, 108 at risk HIV-) in the Brooklyn Women's Interagency HIV Study (WIHS) with measured levels of ghrelin, amylin and gastric inhibitory peptide (GIP), also known as glucose-dependent insulinotropic polypeptide. Cross-sectional analyses using linear regression models estimated the relationship between gut hormones and Trails A, Trails B, Stroop interference time, Stroop word recall, Stroop color naming and reading, and Symbol Digit Modalities Test (SDMT) with consideration for age, HIV infection status, Wide Range Achievement Test score (WRAT), CD4 count, insulin resistance, drug use, and race/ethnicity. RESULTS: Among women at mid-life with chronic (at least 10 years) HIV infection or among those at risk, ghrelin, amylin and GIP were differentially related to cognitive test performance by cognitive domain. Better performance on cognitive tests was generally associated with higher ghrelin, amylin and GIP levels. However, the strength of association varied, as did significance level by HIV status. CONCLUSION: Previous analyses in WIHS participants have suggested that higher BMI, waist, and WHR are associated with better cognitive function among women at mid-life with HIV infection. This study indicates that higher gut hormone levels are also associated with better cognition. Gut hormones may provide additional mechanistic insights regarding the association between obesity and Type 2 diabetes and cognition in middle-aged HIV+ and at risk HIV- women. In addition, measuring these hormones longitudinally would add to the understanding of mechanisms of actions of these hormones and their use as potential clinical tools for early identification and intervention on cognitive decline in this vulnerable population. SN - 2155-9562 UR - https://www.unboundmedicine.com/medline/citation/28690913/Ghrelin,_Amylin,_Gastric_Inhibitory_Peptide_and_Cognition_in_Middle-Aged_HIV-Infected_and_Uninfected_Women:_The_Women's_Interagency_HIV_Study L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28690913/ DB - PRIME DP - Unbound Medicine ER -