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Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain before and after pentylenetetrazol-induced convulsion.
Neuropeptides. 1986 Jan; 7(1):63-71.N

Abstract

Wistar rats were injected with a convulsant doze of pentylenetetrazol (PTZ) (50 mg/kg, i.p.). Somatostatin-like immunoreactivity (SLI) and 125I-Tyr11-somatostatin binding were measured in various brain areas immediately after PTZ injection, after the first head twitches, and 15 minutes, 1 h, 4 h, and 24 h after generalized tonic-clonic convulsions. SLI tended to decrease in the striatum (p less than 0.02), frontal cortex, hippocampus, and hypothalamus 1 hour after convulsion. Specific somatostatin binding remained stable. According to our results, somatostatin is not connected to initiation or spread of seizure but may play some role in depressing seizures.

Authors

Pitkänen A
No affiliation info available
Sirviö J
No affiliation info available
Jolkkonen J
No affiliation info available
Riekkinen P
No affiliation info available

MeSH

AnimalsBrainFrontal LobeHippocampusHypothalamusMalePentylenetetrazoleRatsRats, Inbred StrainsReceptors, Cell SurfaceReceptors, SomatostatinSeizuresSomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2869441

Citation

Pitkänen, A, et al. "Somatostatin-like Immunoreactivity and Somatostatin Receptor Binding in Rat Brain Before and After Pentylenetetrazol-induced Convulsion." Neuropeptides, vol. 7, no. 1, 1986, pp. 63-71.
Pitkänen A, Sirviö J, Jolkkonen J, et al. Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain before and after pentylenetetrazol-induced convulsion. Neuropeptides. 1986;7(1):63-71.
Pitkänen, A., Sirviö, J., Jolkkonen, J., & Riekkinen, P. (1986). Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain before and after pentylenetetrazol-induced convulsion. Neuropeptides, 7(1), 63-71.
Pitkänen A, et al. Somatostatin-like Immunoreactivity and Somatostatin Receptor Binding in Rat Brain Before and After Pentylenetetrazol-induced Convulsion. Neuropeptides. 1986;7(1):63-71. PubMed PMID: 2869441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain before and after pentylenetetrazol-induced convulsion. AU - Pitkänen,A, AU - Sirviö,J, AU - Jolkkonen,J, AU - Riekkinen,P, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 63 EP - 71 JF - Neuropeptides JO - Neuropeptides VL - 7 IS - 1 N2 - Wistar rats were injected with a convulsant doze of pentylenetetrazol (PTZ) (50 mg/kg, i.p.). Somatostatin-like immunoreactivity (SLI) and 125I-Tyr11-somatostatin binding were measured in various brain areas immediately after PTZ injection, after the first head twitches, and 15 minutes, 1 h, 4 h, and 24 h after generalized tonic-clonic convulsions. SLI tended to decrease in the striatum (p less than 0.02), frontal cortex, hippocampus, and hypothalamus 1 hour after convulsion. Specific somatostatin binding remained stable. According to our results, somatostatin is not connected to initiation or spread of seizure but may play some role in depressing seizures. SN - 0143-4179 UR - https://www.unboundmedicine.com/medline/citation/2869441/Somatostatin_like_immunoreactivity_and_somatostatin_receptor_binding_in_rat_brain_before_and_after_pentylenetetrazol_induced_convulsion_ DB - PRIME DP - Unbound Medicine ER -