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Somatostatin, insulin and glucagon after arginine stimulation in active and treated acromegaly.
Acta Endocrinol (Copenh). 1986 Feb; 111(2):145-50.AE

Abstract

Ten acromegalic patients, 28-71 years old, were compared with 10 normal controls, 21-39 years old. In another study, 7 patients with active acromegaly, 19-70 years old, were investigated before and 4-9 months following transsphenoidal adenectomy and radiation. They were all investigated following an arginine infusion (0.5 g/kg/20 min). Although the mean plasma somatostatin (somatotrophin release inhibiting factor (SRIF] was somewhat higher in acromegalic patients compared to normal controls (mean basal values 21 +/- 3.8 and 16.6 +/- 2.1 pmol/l, respectively), the difference was not significant. The patients had higher serum insulin (peak values 118 +/- 23.9 and 63 +/- 11.8 mU/l, respectively) and lower plasma glucagon (peak values 171 +/- 29.0 and 310 +/- 52.7 pmol/l, respectively). Plasma SRIF increased during arginine infusion, but the concentrations were similar before and following the operation (mean basal values 18.2 +/- 2.6 and 15.2 +/- 2.3 pmol/l, respectively). Serum insulin was significantly higher before the operation (peak values 154 +/- 38.8 and 91 +/- 24.9 mU/l, respectively). Plasma glucagon was similar before and after the operation (peak values 143 +/- 23.4 and 127 +/- 22.7 pmol/l, respectively). Plasma SRIF is similar in active acromegaly and normal controls, and in acromegaly before and following treatment, despite differences in serum growth hormone (GH), serum insulin and plasma glucagon. This points towards a modulating role for GH on plasma SRIF, possibly by affecting the other islet cell hormones.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2869632

Citation

Skare, S, et al. "Somatostatin, Insulin and Glucagon After Arginine Stimulation in Active and Treated Acromegaly." Acta Endocrinologica, vol. 111, no. 2, 1986, pp. 145-50.
Skare S, Kriz V, Hanssen KF. Somatostatin, insulin and glucagon after arginine stimulation in active and treated acromegaly. Acta Endocrinol (Copenh). 1986;111(2):145-50.
Skare, S., Kriz, V., & Hanssen, K. F. (1986). Somatostatin, insulin and glucagon after arginine stimulation in active and treated acromegaly. Acta Endocrinologica, 111(2), 145-50.
Skare S, Kriz V, Hanssen KF. Somatostatin, Insulin and Glucagon After Arginine Stimulation in Active and Treated Acromegaly. Acta Endocrinol (Copenh). 1986;111(2):145-50. PubMed PMID: 2869632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatostatin, insulin and glucagon after arginine stimulation in active and treated acromegaly. AU - Skare,S, AU - Kriz,V, AU - Hanssen,K F, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 145 EP - 50 JF - Acta endocrinologica JO - Acta Endocrinol (Copenh) VL - 111 IS - 2 N2 - Ten acromegalic patients, 28-71 years old, were compared with 10 normal controls, 21-39 years old. In another study, 7 patients with active acromegaly, 19-70 years old, were investigated before and 4-9 months following transsphenoidal adenectomy and radiation. They were all investigated following an arginine infusion (0.5 g/kg/20 min). Although the mean plasma somatostatin (somatotrophin release inhibiting factor (SRIF] was somewhat higher in acromegalic patients compared to normal controls (mean basal values 21 +/- 3.8 and 16.6 +/- 2.1 pmol/l, respectively), the difference was not significant. The patients had higher serum insulin (peak values 118 +/- 23.9 and 63 +/- 11.8 mU/l, respectively) and lower plasma glucagon (peak values 171 +/- 29.0 and 310 +/- 52.7 pmol/l, respectively). Plasma SRIF increased during arginine infusion, but the concentrations were similar before and following the operation (mean basal values 18.2 +/- 2.6 and 15.2 +/- 2.3 pmol/l, respectively). Serum insulin was significantly higher before the operation (peak values 154 +/- 38.8 and 91 +/- 24.9 mU/l, respectively). Plasma glucagon was similar before and after the operation (peak values 143 +/- 23.4 and 127 +/- 22.7 pmol/l, respectively). Plasma SRIF is similar in active acromegaly and normal controls, and in acromegaly before and following treatment, despite differences in serum growth hormone (GH), serum insulin and plasma glucagon. This points towards a modulating role for GH on plasma SRIF, possibly by affecting the other islet cell hormones. SN - 0001-5598 UR - https://www.unboundmedicine.com/medline/citation/2869632/Somatostatin_insulin_and_glucagon_after_arginine_stimulation_in_active_and_treated_acromegaly_ DB - PRIME DP - Unbound Medicine ER -