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Bio-fabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens.
Environ Sci Pollut Res Int. 2018 Apr; 25(11):10392-10406.ES

Abstract

In recent years, the use of nanoparticle-based antimicrobials has been increased due to many advantages over conventional agrochemicals. This study investigates the utilization of common medicinal plant dandelion, Taraxacum officinale, for the synthesis of silver nanoparticles (TOL-AgNPs). AgNPs were evaluated for antimicrobial activity against two important phytopathogens, Xanthomonas axonopodis and Pseudomonas syringae. The morphology, size, and structure of TOL-AgNPs were characterized using UV-visible spectroscopy and X-ray diffraction (XRD). Fourier transform infrared spectroscopy (FT-IR) showed the presence of phytochemicals involved during synthesis of NPs. High-resolution transmission electron microscopy (HR-TEM) analysis shed light on the size of monodispersed spherical AgNPs ranging between 5 and 30 nm, with an average particle size of about 15 nm. The TOL-AgNPs (at 20 μg/mL concentration) showed significant antibacterial activity with significant growth inhibition of phytopathogens X. axonopodis (22.0 ± 0.84 mm) and P. syringae (19.5 ± 0.66 mm). The synthesized AgNPs had higher antibacterial activity in comparison with commercial AgNPs. Synergistic assays with standard antibiotics revealed that nanoformulations with tetracycline showed better broad-spectrum efficiency to control phytopathogens. They also possessed significant antioxidant potential in terms of ABTS (IC50 = 45.6 μg/mL), DPPH (IC50 = 56.1 μg/mL), and NO (IC50 = 55.2 μg/mL) free radical scavenging activity. The TOL-AgNPs showed high cytotoxic effect against human liver cancer cells (HepG2). Overall, dandelion-mediated AgNPs synthesis can represent a novel approach to develop effective antimicrobial and anticancer drugs with a cheap and eco-friendly nature.

Authors+Show Affiliations

Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea.Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy. The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy.Green Processing, Bioremediation and Alternative Energies Research Group (GPBAE), Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Vietnam.Department of Environmental Science and Engineering, Ewha Womans University, Seoul, South Korea.Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea. gdsaratale@dongguk.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28699009

Citation

Saratale, Rijuta G., et al. "Bio-fabrication of Silver Nanoparticles Using the Leaf Extract of an Ancient Herbal Medicine, Dandelion (Taraxacum Officinale), Evaluation of Their Antioxidant, Anticancer Potential, and Antimicrobial Activity Against Phytopathogens." Environmental Science and Pollution Research International, vol. 25, no. 11, 2018, pp. 10392-10406.
Saratale RG, Benelli G, Kumar G, et al. Bio-fabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens. Environ Sci Pollut Res Int. 2018;25(11):10392-10406.
Saratale, R. G., Benelli, G., Kumar, G., Kim, D. S., & Saratale, G. D. (2018). Bio-fabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens. Environmental Science and Pollution Research International, 25(11), 10392-10406. https://doi.org/10.1007/s11356-017-9581-5
Saratale RG, et al. Bio-fabrication of Silver Nanoparticles Using the Leaf Extract of an Ancient Herbal Medicine, Dandelion (Taraxacum Officinale), Evaluation of Their Antioxidant, Anticancer Potential, and Antimicrobial Activity Against Phytopathogens. Environ Sci Pollut Res Int. 2018;25(11):10392-10406. PubMed PMID: 28699009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bio-fabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens. AU - Saratale,Rijuta G, AU - Benelli,Giovanni, AU - Kumar,Gopalakrishnan, AU - Kim,Dong Su, AU - Saratale,Ganesh D, Y1 - 2017/07/11/ PY - 2017/03/29/received PY - 2017/06/19/accepted PY - 2017/7/13/pubmed PY - 2018/12/29/medline PY - 2017/7/13/entrez KW - Antibacterial activity KW - Antioxidant activity KW - Liver cancer cells HepG2 KW - Phytopathogens KW - Silver nanoparticles KW - Taraxacum officinale SP - 10392 EP - 10406 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 25 IS - 11 N2 - In recent years, the use of nanoparticle-based antimicrobials has been increased due to many advantages over conventional agrochemicals. This study investigates the utilization of common medicinal plant dandelion, Taraxacum officinale, for the synthesis of silver nanoparticles (TOL-AgNPs). AgNPs were evaluated for antimicrobial activity against two important phytopathogens, Xanthomonas axonopodis and Pseudomonas syringae. The morphology, size, and structure of TOL-AgNPs were characterized using UV-visible spectroscopy and X-ray diffraction (XRD). Fourier transform infrared spectroscopy (FT-IR) showed the presence of phytochemicals involved during synthesis of NPs. High-resolution transmission electron microscopy (HR-TEM) analysis shed light on the size of monodispersed spherical AgNPs ranging between 5 and 30 nm, with an average particle size of about 15 nm. The TOL-AgNPs (at 20 μg/mL concentration) showed significant antibacterial activity with significant growth inhibition of phytopathogens X. axonopodis (22.0 ± 0.84 mm) and P. syringae (19.5 ± 0.66 mm). The synthesized AgNPs had higher antibacterial activity in comparison with commercial AgNPs. Synergistic assays with standard antibiotics revealed that nanoformulations with tetracycline showed better broad-spectrum efficiency to control phytopathogens. They also possessed significant antioxidant potential in terms of ABTS (IC50 = 45.6 μg/mL), DPPH (IC50 = 56.1 μg/mL), and NO (IC50 = 55.2 μg/mL) free radical scavenging activity. The TOL-AgNPs showed high cytotoxic effect against human liver cancer cells (HepG2). Overall, dandelion-mediated AgNPs synthesis can represent a novel approach to develop effective antimicrobial and anticancer drugs with a cheap and eco-friendly nature. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/28699009/Bio_fabrication_of_silver_nanoparticles_using_the_leaf_extract_of_an_ancient_herbal_medicine_dandelion__Taraxacum_officinale__evaluation_of_their_antioxidant_anticancer_potential_and_antimicrobial_activity_against_phytopathogens_ L2 - https://dx.doi.org/10.1007/s11356-017-9581-5 DB - PRIME DP - Unbound Medicine ER -