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Vitamin D Status Is Associated with Hepcidin and Hemoglobin Concentrations in Children with Inflammatory Bowel Disease.
Inflamm Bowel Dis. 2017 09; 23(9):1650-1658.IB

Abstract

BACKGROUND

Anemia, iron deficiency, and hypovitaminosis D are well-known comorbidities in inflammatory bowel disease (IBD). Epidemiologic studies have linked vitamin D deficiency with increased risk of anemia, and in vitro studies suggest that vitamin D may improve iron recycling through downregulatory effects on hepcidin and proinflammatory cytokines.

METHODS

We aimed to investigate the association of vitamin D status with inflammation, iron biomarkers, and anemia in pediatric IBD. Cross-sectional data were obtained from N = 69 patients with IBD aged 5 to <19 years. Iron biomarkers (ferritin, soluble transferrin receptor), and 25-hydroxyvitamin D (25(OH)D), inflammatory biomarkers (C-reactive protein and α-1-acid glycoprotein), hepcidin, and hemoglobin were collected. Iron biomarkers were regression corrected for inflammation. Multivariable logistic/linear models were used to examine the associations of 25(OH)D with inflammation, iron status, hepcidin, and anemia.

RESULTS

Approximately 50% of subjects were inflamed (C-reactive protein >5 mg/L or α-1-acid glycoprotein >1 g/L). Iron deficiency prevalence (inflammation-corrected ferritin <15 μg/L or soluble transferrin receptor >8.3 mg/L) was 67%; anemia was 36%, and vitamin D insufficiency (25(OH)D <30 ng/mL) was 77%. In linear regression models, vitamin D insufficiency was associated with increased hepcidin levels (β [SE] = 0.6 [0.2], P = 0.01) and reduced hemoglobin (β [SE] = -0.9 [0.5], P = 0.046), controlling for age, sex, race, insurance status, body mass index for age, inflammation, disease diagnosis (ulcerative colitis versus Crohn's disease), and disease duration, compared with 25(OH)D ≥30 ng/mL.

CONCLUSIONS

Our results suggest that concentrations of 25(OH)D ≥30 ng/mL are associated with lower hepcidin and higher hemoglobin levels. Further research is needed to clarify the association of vitamin D with inflammation, iron status, and anemia in pediatric IBD.

Authors+Show Affiliations

*Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; †Division of Gastroenterology, Hepatology and Nutrition, Children's Healthcare of Atlanta, Atlanta, Georgia; ‡Nutrition and Health Sciences Program, Laney Graduate School, Emory University, Atlanta, Georgia; §Department of Medicine, Emory University School of Medicine; and ‖Atlanta VA Medical Center, Atlanta, Georgia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28700535

Citation

Syed, Sana, et al. "Vitamin D Status Is Associated With Hepcidin and Hemoglobin Concentrations in Children With Inflammatory Bowel Disease." Inflammatory Bowel Diseases, vol. 23, no. 9, 2017, pp. 1650-1658.
Syed S, Michalski ES, Tangpricha V, et al. Vitamin D Status Is Associated with Hepcidin and Hemoglobin Concentrations in Children with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017;23(9):1650-1658.
Syed, S., Michalski, E. S., Tangpricha, V., Chesdachai, S., Kumar, A., Prince, J., Ziegler, T. R., Suchdev, P. S., & Kugathasan, S. (2017). Vitamin D Status Is Associated with Hepcidin and Hemoglobin Concentrations in Children with Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 23(9), 1650-1658. https://doi.org/10.1097/MIB.0000000000001178
Syed S, et al. Vitamin D Status Is Associated With Hepcidin and Hemoglobin Concentrations in Children With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017;23(9):1650-1658. PubMed PMID: 28700535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Status Is Associated with Hepcidin and Hemoglobin Concentrations in Children with Inflammatory Bowel Disease. AU - Syed,Sana, AU - Michalski,Ellen S, AU - Tangpricha,Vin, AU - Chesdachai,Supavit, AU - Kumar,Archana, AU - Prince,Jarod, AU - Ziegler,Thomas R, AU - Suchdev,Parminder S, AU - Kugathasan,Subra, PY - 2017/7/13/pubmed PY - 2018/5/16/medline PY - 2017/7/13/entrez SP - 1650 EP - 1658 JF - Inflammatory bowel diseases JO - Inflamm. Bowel Dis. VL - 23 IS - 9 N2 - BACKGROUND: Anemia, iron deficiency, and hypovitaminosis D are well-known comorbidities in inflammatory bowel disease (IBD). Epidemiologic studies have linked vitamin D deficiency with increased risk of anemia, and in vitro studies suggest that vitamin D may improve iron recycling through downregulatory effects on hepcidin and proinflammatory cytokines. METHODS: We aimed to investigate the association of vitamin D status with inflammation, iron biomarkers, and anemia in pediatric IBD. Cross-sectional data were obtained from N = 69 patients with IBD aged 5 to <19 years. Iron biomarkers (ferritin, soluble transferrin receptor), and 25-hydroxyvitamin D (25(OH)D), inflammatory biomarkers (C-reactive protein and α-1-acid glycoprotein), hepcidin, and hemoglobin were collected. Iron biomarkers were regression corrected for inflammation. Multivariable logistic/linear models were used to examine the associations of 25(OH)D with inflammation, iron status, hepcidin, and anemia. RESULTS: Approximately 50% of subjects were inflamed (C-reactive protein >5 mg/L or α-1-acid glycoprotein >1 g/L). Iron deficiency prevalence (inflammation-corrected ferritin <15 μg/L or soluble transferrin receptor >8.3 mg/L) was 67%; anemia was 36%, and vitamin D insufficiency (25(OH)D <30 ng/mL) was 77%. In linear regression models, vitamin D insufficiency was associated with increased hepcidin levels (β [SE] = 0.6 [0.2], P = 0.01) and reduced hemoglobin (β [SE] = -0.9 [0.5], P = 0.046), controlling for age, sex, race, insurance status, body mass index for age, inflammation, disease diagnosis (ulcerative colitis versus Crohn's disease), and disease duration, compared with 25(OH)D ≥30 ng/mL. CONCLUSIONS: Our results suggest that concentrations of 25(OH)D ≥30 ng/mL are associated with lower hepcidin and higher hemoglobin levels. Further research is needed to clarify the association of vitamin D with inflammation, iron status, and anemia in pediatric IBD. SN - 1536-4844 UR - https://www.unboundmedicine.com/medline/citation/28700535/Vitamin_D_Status_Is_Associated_with_Hepcidin_and_Hemoglobin_Concentrations_in_Children_with_Inflammatory_Bowel_Disease_ L2 - https://academic.oup.com/ibdjournal/article-lookup/doi/10.1097/MIB.0000000000001178 DB - PRIME DP - Unbound Medicine ER -