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Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease.
Front Aging Neurosci. 2017; 9:206.FA

Abstract

Levodopa is considered to be the most effective symptomatic drug for Parkinson's disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose wearing off and unpredictable "on-off"). Protein-rich diets and elevated plasma concentrations of large neutral amino acids have been proved to impair the therapeutic effect of levodopa by reducing its absorption and influx into the brain. On the other hand, the protein-restricted diets including low-protein diet (LPD), protein-redistribution diet (PRD) and PRD with use of low-protein products can all improve the efficacy of levodopa in patients with motor fluctuations. However, it should be noted that protein-restricted diets may also contribute to several side effects, including dyskinesia, weight loss, and malnutrition (e.g., protein and calcium insufficiency). Together, protein-restricted diets are an effective approach to improve motor fluctuations in PD patients, while long-term adherence to these diets requires monitoring for side effects.

Authors+Show Affiliations

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and TechnologyWuhan, China.Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28701947

Citation

Wang, Luxi, et al. "Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease." Frontiers in Aging Neuroscience, vol. 9, 2017, p. 206.
Wang L, Xiong N, Huang J, et al. Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease. Front Aging Neurosci. 2017;9:206.
Wang, L., Xiong, N., Huang, J., Guo, S., Liu, L., Han, C., Zhang, G., Jiang, H., Ma, K., Xia, Y., Xu, X., Li, J., Liu, J. Y., & Wang, T. (2017). Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease. Frontiers in Aging Neuroscience, 9, 206. https://doi.org/10.3389/fnagi.2017.00206
Wang L, et al. Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease. Front Aging Neurosci. 2017;9:206. PubMed PMID: 28701947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease. AU - Wang,Luxi, AU - Xiong,Nian, AU - Huang,Jinsha, AU - Guo,Shiyi, AU - Liu,Ling, AU - Han,Chao, AU - Zhang,Guoxin, AU - Jiang,Haiyang, AU - Ma,Kai, AU - Xia,Yun, AU - Xu,Xiaoyun, AU - Li,Jie, AU - Liu,Jing Y, AU - Wang,Tao, Y1 - 2017/06/28/ PY - 2016/12/21/received PY - 2017/06/08/accepted PY - 2017/7/14/entrez PY - 2017/7/14/pubmed PY - 2017/7/14/medline KW - Parkinson's disease KW - diet therapy KW - fluctuation KW - levodopa KW - protein SP - 206 EP - 206 JF - Frontiers in aging neuroscience JO - Front Aging Neurosci VL - 9 N2 - Levodopa is considered to be the most effective symptomatic drug for Parkinson's disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose wearing off and unpredictable "on-off"). Protein-rich diets and elevated plasma concentrations of large neutral amino acids have been proved to impair the therapeutic effect of levodopa by reducing its absorption and influx into the brain. On the other hand, the protein-restricted diets including low-protein diet (LPD), protein-redistribution diet (PRD) and PRD with use of low-protein products can all improve the efficacy of levodopa in patients with motor fluctuations. However, it should be noted that protein-restricted diets may also contribute to several side effects, including dyskinesia, weight loss, and malnutrition (e.g., protein and calcium insufficiency). Together, protein-restricted diets are an effective approach to improve motor fluctuations in PD patients, while long-term adherence to these diets requires monitoring for side effects. SN - 1663-4365 UR - https://www.unboundmedicine.com/medline/citation/28701947/Protein_Restricted_Diets_for_Ameliorating_Motor_Fluctuations_in_Parkinson's_Disease_ L2 - https://doi.org/10.3389/fnagi.2017.00206 DB - PRIME DP - Unbound Medicine ER -
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