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Direct and indirect measurements of enhanced phenolic bioavailability from litchi pericarp procyanidins by Lactobacillus casei-01.
Food Funct. 2017 Aug 01; 8(8):2760-2770.FF

Abstract

Litchi pericarp procyanidins (LPP) are dietary supplements with high antioxidant activity, but poor oral bioavailability and efficacy. Lactobacillus casei (L. casei-01) can transform flavan-3-ols from litchi pericarp and increase their antioxidant ability; thus, L. casei-01 with LPP was administered to rats for four and eight weeks to study the effect of such a combination on metabolic parameters and on phase II metabolism and detoxification pathways in the liver as an indirect measure for phenolic bioavailability. Our data indicated that the T-AOC of the plasma, the liver GSH-Px and GSH-ST activity, and the expression of UGT and SULT isoforms in the liver of the rats were all enhanced after the eight-week administration compared with those of the control. However, at 1 h after administration the concentration of (-)-epicatechin in the combined system was lower than that obtained after the ingestion of LPP alone, suggesting that L. casei-01 enhances the bioavailability of phenolics from LPP by modulating the transformation to other compounds but not by increasing its absorption in the native form.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li S
College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China. lishuyisz@sina.com.
Li X
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.
Shpigelman A
Faculty of Biotechnology and Food Engineering, Technion, Israel Institute of Technology, Haifa, Israel.
Lorenzo JM
Centro Tecnológico de la Carne de Galicia, c/Galicia, 4, 32900 San Ciprián de Viñas, Ourense, Spain. jmlorenzo@ceteca.net.
Montesano D
Dipartimento di Scienze Farmaceutiche, Sezione di Scienza degli Alimenti e Nutrizione, Università di Perugia, Via S. Costanzo, 1, Perugia, Italy.
Barba FJ
Nutrition and Food Science Area, Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Faculty of Pharmacy, Universitat de València, Avda. Vicent Andrés Estellés, s/n, 46100 Burjassot, València, Spain.

MeSH

AnimalsBiflavonoidsBiotransformationCatechinFruitGlutathione PeroxidaseGlutathione TransferaseLactobacillus caseiLitchiLiverMalePhenolsPlant ExtractsProanthocyanidinsRatsRats, Sprague-Dawley

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28702654

Citation

Li, Shuyi, et al. "Direct and Indirect Measurements of Enhanced Phenolic Bioavailability From Litchi Pericarp Procyanidins By Lactobacillus Casei-01." Food & Function, vol. 8, no. 8, 2017, pp. 2760-2770.
Li S, Li X, Shpigelman A, et al. Direct and indirect measurements of enhanced phenolic bioavailability from litchi pericarp procyanidins by Lactobacillus casei-01. Food Funct. 2017;8(8):2760-2770.
Li, S., Li, X., Shpigelman, A., Lorenzo, J. M., Montesano, D., & Barba, F. J. (2017). Direct and indirect measurements of enhanced phenolic bioavailability from litchi pericarp procyanidins by Lactobacillus casei-01. Food & Function, 8(8), 2760-2770. https://doi.org/10.1039/c7fo00749c
Li S, et al. Direct and Indirect Measurements of Enhanced Phenolic Bioavailability From Litchi Pericarp Procyanidins By Lactobacillus Casei-01. Food Funct. 2017 Aug 1;8(8):2760-2770. PubMed PMID: 28702654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Direct and indirect measurements of enhanced phenolic bioavailability from litchi pericarp procyanidins by Lactobacillus casei-01. AU - Li,Shuyi, AU - Li,Xiaopeng, AU - Shpigelman,Avi, AU - Lorenzo,Jose M, AU - Montesano,Domenico, AU - Barba,Francisco J, Y1 - 2017/07/12/ PY - 2017/7/14/pubmed PY - 2017/12/16/medline PY - 2017/7/14/entrez SP - 2760 EP - 2770 JF - Food & function JO - Food Funct VL - 8 IS - 8 N2 - Litchi pericarp procyanidins (LPP) are dietary supplements with high antioxidant activity, but poor oral bioavailability and efficacy. Lactobacillus casei (L. casei-01) can transform flavan-3-ols from litchi pericarp and increase their antioxidant ability; thus, L. casei-01 with LPP was administered to rats for four and eight weeks to study the effect of such a combination on metabolic parameters and on phase II metabolism and detoxification pathways in the liver as an indirect measure for phenolic bioavailability. Our data indicated that the T-AOC of the plasma, the liver GSH-Px and GSH-ST activity, and the expression of UGT and SULT isoforms in the liver of the rats were all enhanced after the eight-week administration compared with those of the control. However, at 1 h after administration the concentration of (-)-epicatechin in the combined system was lower than that obtained after the ingestion of LPP alone, suggesting that L. casei-01 enhances the bioavailability of phenolics from LPP by modulating the transformation to other compounds but not by increasing its absorption in the native form. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/28702654/Direct_and_indirect_measurements_of_enhanced_phenolic_bioavailability_from_litchi_pericarp_procyanidins_by_Lactobacillus_casei_01_ L2 - https://doi.org/10.1039/c7fo00749c DB - PRIME DP - Unbound Medicine ER -