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Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis.
Proc Natl Acad Sci U S A. 1979 Apr; 76(4):2047-51.PN

Abstract

Studies on the immunoprecipitation of the proteins of several different measles and subacute sclerosing panencephalitis (SSPE) virus strains from lysates of infected cells have revealed a relative lack of antibodies to the nonglycosylated viral membrane protein (M) in the sera of patients with SSPE, in contrast to a high level of antibodies to other viral proteins. No evidence was found for the existence of a large number of antigenically unique M proteins. In contrast to SSPE sera, other hyperimmune human or rabbit sera precipitated M protein as well as the other viral proteins. The results suggest that in patients with SSPE there is either diminished synthesis of M, or it is not recognized normally by the immune system, and that an abnormality in M protein is involved in the pathogenesis of SSPE. Although differences in electrophoretic mobility of the M proteins and several other viral proteins were observed among different SSPE and measles strains, there was no pattern characteristic of SSPE strains, nor could these strains be distinguished by peptide mapping.

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Authors

Hall WW
No affiliation info available
Lamb RA
No affiliation info available
Choppin PW
No affiliation info available

MeSH

Antibodies, ViralHumansMeasles virusMembrane ProteinsSSPE VirusSubacute Sclerosing PanencephalitisViral Proteins

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

287042

Citation

Hall, W W., et al. "Measles and Subacute Sclerosing Panencephalitis Virus Proteins: Lack of Antibodies to the M Protein in Patients With Subacute Sclerosing Panencephalitis." Proceedings of the National Academy of Sciences of the United States of America, vol. 76, no. 4, 1979, pp. 2047-51.
Hall WW, Lamb RA, Choppin PW. Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. Proc Natl Acad Sci U S A. 1979;76(4):2047-51.
Hall, W. W., Lamb, R. A., & Choppin, P. W. (1979). Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. Proceedings of the National Academy of Sciences of the United States of America, 76(4), 2047-51.
Hall WW, Lamb RA, Choppin PW. Measles and Subacute Sclerosing Panencephalitis Virus Proteins: Lack of Antibodies to the M Protein in Patients With Subacute Sclerosing Panencephalitis. Proc Natl Acad Sci U S A. 1979;76(4):2047-51. PubMed PMID: 287042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. AU - Hall,W W, AU - Lamb,R A, AU - Choppin,P W, PY - 1979/4/1/pubmed PY - 1979/4/1/medline PY - 1979/4/1/entrez SP - 2047 EP - 51 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 76 IS - 4 N2 - Studies on the immunoprecipitation of the proteins of several different measles and subacute sclerosing panencephalitis (SSPE) virus strains from lysates of infected cells have revealed a relative lack of antibodies to the nonglycosylated viral membrane protein (M) in the sera of patients with SSPE, in contrast to a high level of antibodies to other viral proteins. No evidence was found for the existence of a large number of antigenically unique M proteins. In contrast to SSPE sera, other hyperimmune human or rabbit sera precipitated M protein as well as the other viral proteins. The results suggest that in patients with SSPE there is either diminished synthesis of M, or it is not recognized normally by the immune system, and that an abnormality in M protein is involved in the pathogenesis of SSPE. Although differences in electrophoretic mobility of the M proteins and several other viral proteins were observed among different SSPE and measles strains, there was no pattern characteristic of SSPE strains, nor could these strains be distinguished by peptide mapping. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/287042/Measles_and_subacute_sclerosing_panencephalitis_virus_proteins:_lack_of_antibodies_to_the_M_protein_in_patients_with_subacute_sclerosing_panencephalitis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/287042/ DB - PRIME DP - Unbound Medicine ER -