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Effects of D1 and D2 receptor antagonists on the discriminative stimulus effects of methylendioxypyrovalerone and mephedrone in male Sprague-Dawley rats trained to discriminate D-amphetamine.
Behav Pharmacol. 2017 10; 28(7):586-589.BP

Abstract

Psychopharmacology research has amassed substantial evidence for similarities between synthetic cathinones and other commonly abused psychostimulants. Few studies have utilized drug discrimination methods to investigate synthetic cathinones, and the precise neurochemical substrates underlying their interoceptive effects have not been examined. The present study assessed the involvement of D1 and D2 dopaminergic receptors in the stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) and mephedrone (MEPH) in rats trained to discriminate D-amphetamine. Eight male Sprague-Dawley rats were trained to discriminate 0.5 mg/kg D-amphetamine (AMPH) from saline. Dose-response curves were then generated with AMPH (0.0-1.0 mg/kg), MDPV (0.0-1.0 mg/kg), and MEPH (0.0-2.0 mg/kg). Subsequently, Sch 39166 (0.3 mg/kg) and haloperidol (0.5 mg/kg) were administered in combination with select doses of MDPV and MEPH. Both MDPV and MEPH produced full substitution for AMPH. Sch 39166 produced a downward shift in the MDPV and MEPH dose-response curves and haloperidol produced similar results with MDPV. These preliminary findings indicate that MDPV and MEPH produce interoceptive stimuli that are similar to those produced by AMPH and that D1 and D2 dopamine receptors contribute to these effects. Additional studies are warranted to investigate the contribution of other receptor mechanisms involved in the interoceptive stimuli produced by synthetic cathinones.

Authors+Show Affiliations

Department of Psychology, Western Michigan University, Kalamazoo, Michigan, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28704276

Citation

Harvey, Eric L., et al. "Effects of D1 and D2 Receptor Antagonists On the Discriminative Stimulus Effects of Methylendioxypyrovalerone and Mephedrone in Male Sprague-Dawley Rats Trained to Discriminate D-amphetamine." Behavioural Pharmacology, vol. 28, no. 7, 2017, pp. 586-589.
Harvey EL, Burroughs RL, Baker LE. Effects of D1 and D2 receptor antagonists on the discriminative stimulus effects of methylendioxypyrovalerone and mephedrone in male Sprague-Dawley rats trained to discriminate D-amphetamine. Behav Pharmacol. 2017;28(7):586-589.
Harvey, E. L., Burroughs, R. L., & Baker, L. E. (2017). Effects of D1 and D2 receptor antagonists on the discriminative stimulus effects of methylendioxypyrovalerone and mephedrone in male Sprague-Dawley rats trained to discriminate D-amphetamine. Behavioural Pharmacology, 28(7), 586-589. https://doi.org/10.1097/FBP.0000000000000328
Harvey EL, Burroughs RL, Baker LE. Effects of D1 and D2 Receptor Antagonists On the Discriminative Stimulus Effects of Methylendioxypyrovalerone and Mephedrone in Male Sprague-Dawley Rats Trained to Discriminate D-amphetamine. Behav Pharmacol. 2017;28(7):586-589. PubMed PMID: 28704276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of D1 and D2 receptor antagonists on the discriminative stimulus effects of methylendioxypyrovalerone and mephedrone in male Sprague-Dawley rats trained to discriminate D-amphetamine. AU - Harvey,Eric L, AU - Burroughs,Rachel L, AU - Baker,Lisa E, PY - 2017/7/14/pubmed PY - 2018/4/17/medline PY - 2017/7/14/entrez SP - 586 EP - 589 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 28 IS - 7 N2 - Psychopharmacology research has amassed substantial evidence for similarities between synthetic cathinones and other commonly abused psychostimulants. Few studies have utilized drug discrimination methods to investigate synthetic cathinones, and the precise neurochemical substrates underlying their interoceptive effects have not been examined. The present study assessed the involvement of D1 and D2 dopaminergic receptors in the stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) and mephedrone (MEPH) in rats trained to discriminate D-amphetamine. Eight male Sprague-Dawley rats were trained to discriminate 0.5 mg/kg D-amphetamine (AMPH) from saline. Dose-response curves were then generated with AMPH (0.0-1.0 mg/kg), MDPV (0.0-1.0 mg/kg), and MEPH (0.0-2.0 mg/kg). Subsequently, Sch 39166 (0.3 mg/kg) and haloperidol (0.5 mg/kg) were administered in combination with select doses of MDPV and MEPH. Both MDPV and MEPH produced full substitution for AMPH. Sch 39166 produced a downward shift in the MDPV and MEPH dose-response curves and haloperidol produced similar results with MDPV. These preliminary findings indicate that MDPV and MEPH produce interoceptive stimuli that are similar to those produced by AMPH and that D1 and D2 dopamine receptors contribute to these effects. Additional studies are warranted to investigate the contribution of other receptor mechanisms involved in the interoceptive stimuli produced by synthetic cathinones. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/28704276/Effects_of_D1_and_D2_receptor_antagonists_on_the_discriminative_stimulus_effects_of_methylendioxypyrovalerone_and_mephedrone_in_male_Sprague_Dawley_rats_trained_to_discriminate_D_amphetamine_ L2 - http://dx.doi.org/10.1097/FBP.0000000000000328 DB - PRIME DP - Unbound Medicine ER -