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Silver nanoparticles functionalized with ampicillin.
Electrophoresis. 2017 11; 38(21):2757-2764.E

Abstract

The resistance of pathogenic bacteria to antibiotics has become a serious problem. The emphasis is placed on the development of new, effective antimicrobial strategies. One of them is the use of AgNPs in association with antibiotic drugs. The aim of this study was to obtain silver nanoparticles functionalized with ampicillin and to investigate the mechanism of binding antibiotics to nanoparticle using high-performance liquid chromatography approach. To confirm the occurrence of silver nanoparticles functionalization, FTIR, MALDI-TOF MS, and DLS analysis and zeta potential measurements were performed. Moreover we assessed the antibacterial activity of biologically synthesized nanoparticles functionalized with ampicillin against a range of gram (+) and gram (-) bacteria strains such as Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus epidermidis, and Escherichia coli.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Rogowska A
Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Poland. Interdisciplinary Centre of Modern Technology, Nicolaus Copernicus University, Poland.
Rafińska K
Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Poland. Interdisciplinary Centre of Modern Technology, Nicolaus Copernicus University, Poland.
Pomastowski P
Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Poland. Interdisciplinary Centre of Modern Technology, Nicolaus Copernicus University, Poland.
Walczak J
Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Poland. Interdisciplinary Centre of Modern Technology, Nicolaus Copernicus University, Poland.
Railean-Plugaru V
Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Poland. Interdisciplinary Centre of Modern Technology, Nicolaus Copernicus University, Poland.
Buszewska-Forajta M
Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gdansk, Poland.
Buszewski B
Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Poland. Interdisciplinary Centre of Modern Technology, Nicolaus Copernicus University, Poland.

MeSH

AmpicillinAnti-Bacterial AgentsChromatography, High Pressure LiquidGram-Negative BacteriaGram-Positive BacteriaHumansMetal NanoparticlesMicrobial Sensitivity TestsParticle SizeSilverSurface Properties

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28704596

Citation

Rogowska, Agnieszka, et al. "Silver Nanoparticles Functionalized With Ampicillin." Electrophoresis, vol. 38, no. 21, 2017, pp. 2757-2764.
Rogowska A, Rafińska K, Pomastowski P, et al. Silver nanoparticles functionalized with ampicillin. Electrophoresis. 2017;38(21):2757-2764.
Rogowska, A., Rafińska, K., Pomastowski, P., Walczak, J., Railean-Plugaru, V., Buszewska-Forajta, M., & Buszewski, B. (2017). Silver nanoparticles functionalized with ampicillin. Electrophoresis, 38(21), 2757-2764. https://doi.org/10.1002/elps.201700093
Rogowska A, et al. Silver Nanoparticles Functionalized With Ampicillin. Electrophoresis. 2017;38(21):2757-2764. PubMed PMID: 28704596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Silver nanoparticles functionalized with ampicillin. AU - Rogowska,Agnieszka, AU - Rafińska,Katarzyna, AU - Pomastowski,Paweł, AU - Walczak,Justyna, AU - Railean-Plugaru,Viorica, AU - Buszewska-Forajta,Magdalena, AU - Buszewski,Bogusław, Y1 - 2017/08/14/ PY - 2017/03/02/received PY - 2017/07/07/revised PY - 2017/07/07/accepted PY - 2017/7/14/pubmed PY - 2018/4/28/medline PY - 2017/7/14/entrez KW - Antibacterial activity KW - Antibiotic KW - Functionalization KW - Silver nanoparticles KW - Sorption SP - 2757 EP - 2764 JF - Electrophoresis JO - Electrophoresis VL - 38 IS - 21 N2 - The resistance of pathogenic bacteria to antibiotics has become a serious problem. The emphasis is placed on the development of new, effective antimicrobial strategies. One of them is the use of AgNPs in association with antibiotic drugs. The aim of this study was to obtain silver nanoparticles functionalized with ampicillin and to investigate the mechanism of binding antibiotics to nanoparticle using high-performance liquid chromatography approach. To confirm the occurrence of silver nanoparticles functionalization, FTIR, MALDI-TOF MS, and DLS analysis and zeta potential measurements were performed. Moreover we assessed the antibacterial activity of biologically synthesized nanoparticles functionalized with ampicillin against a range of gram (+) and gram (-) bacteria strains such as Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus epidermidis, and Escherichia coli. SN - 1522-2683 UR - https://www.unboundmedicine.com/medline/citation/28704596/Silver_nanoparticles_functionalized_with_ampicillin_ L2 - https://doi.org/10.1002/elps.201700093 DB - PRIME DP - Unbound Medicine ER -