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Eradication of Helicobacter pylori infection might improve clinical status of patients with Parkinson's disease, especially on bradykinesia.
Clin Neurol Neurosurg. 2017 Sep; 160:101-104.CN

Abstract

OBJECTIVES

Previous studies have shown that Helicobacter pylori infection might make clinical status worse in patients with Parkinson's disease and Helicobacter pylori eradication might improve clinical status by modifying the pharmacokinetics of L-dopa. Here, we investigate whether Helicobacter pylori eradication could benefit idiopathic parkinsonism and Helicobacter pylori infection will effect which aspect of motor symptom significantly.

PATIENTS AND METHODS

A cohort study involving idiopathic Parkinson's disease patients, screened for Helicobacter status by 13C urea breath test. Clinical status was evaluated by using the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn-Yahr stage. If patients had motor complications, they were quantified at the "on" time. The Helicobacter pylori positive patients could choose to receive Helicobacter pylori eradication or not by themselves. Group 1 was Helicobacter pylori negative patients. Group 2 was Helicobacter pylori positive patients who didn't receive eradication treatment. Group 3 was Helicobacter pylori positive patients who received successful eradication treatment. Repeat clinical assessments and 13C urea breath test was performed at 1year later. Numerical data were expressed as mean±standard deviation (SD) RESULTS: Ninety-four consecutive patients with Parkinson's disease were recruited and underwent the initial 13C urea breath test, but only forty-eight patients successfully completed the total study. In Group 3, the UPDRS-III scores (=Motor Examination Section Scores) were significantly lower 1year later compared to baseline (18.3±8.38 vs. 25.9±8.37, P=0.007). The differences were main in UPDRS-23 (=Finger Taps) (1.7±1.16 vs. 2.4±1.51, P=0.045), UPDRS-25 (Rapid Alternation Movements of Hands) (1.6±1.35 vs. 2.4±1.71, P=0.031) and UPDRS-26 (=Leg Agility) (1.3±1.25 vs.2.1±0.99, P=0.011). There was difference among three groups in the UPDRS-26 (P=0.040) of clinical status change of one year.

CONCLUSION

The eradication of Helicobacter might improve the clinical status of idiopathic parkinsonism, especially on bradykinesia.

Authors+Show Affiliations

Department of Neurology, Beijing Hospital, National Center of Gerontology. No.1 DaHua Road, Dong Dan, Beijing, China. Electronic address: liuhuijing.2007@163.com.Department of Neurology, Beijing Hospital, National Center of Gerontology. No.1 DaHua Road, Dong Dan, Beijing, China. Electronic address: suwendy@126.com.Department of Neurology, Beijing Hospital, National Center of Gerontology. No.1 DaHua Road, Dong Dan, Beijing, China.Department of Neurology, Beijing Hospital, National Center of Gerontology. No.1 DaHua Road, Dong Dan, Beijing, China. Electronic address: raindw@126.com.Department of Neurology, Beijing Hospital, National Center of Gerontology. No.1 DaHua Road, Dong Dan, Beijing, China.Department of Neurology, Beijing Hospital, National Center of Gerontology. No.1 DaHua Road, Dong Dan, Beijing, China.Department of Neurology, Beijing Hospital, National Center of Gerontology. No.1 DaHua Road, Dong Dan, Beijing, China. Electronic address: likai_bjh@hotmail.com.Department of Neurology, Beijing Hospital, National Center of Gerontology. No.1 DaHua Road, Dong Dan, Beijing, China. Electronic address: chenhb_bjh@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28704778

Citation

Liu, Huijing, et al. "Eradication of Helicobacter Pylori Infection Might Improve Clinical Status of Patients With Parkinson's Disease, Especially On Bradykinesia." Clinical Neurology and Neurosurgery, vol. 160, 2017, pp. 101-104.
Liu H, Su W, Li S, et al. Eradication of Helicobacter pylori infection might improve clinical status of patients with Parkinson's disease, especially on bradykinesia. Clin Neurol Neurosurg. 2017;160:101-104.
Liu, H., Su, W., Li, S., Du, W., Ma, X., Jin, Y., Li, K., & Chen, H. (2017). Eradication of Helicobacter pylori infection might improve clinical status of patients with Parkinson's disease, especially on bradykinesia. Clinical Neurology and Neurosurgery, 160, 101-104. https://doi.org/10.1016/j.clineuro.2017.07.003
Liu H, et al. Eradication of Helicobacter Pylori Infection Might Improve Clinical Status of Patients With Parkinson's Disease, Especially On Bradykinesia. Clin Neurol Neurosurg. 2017;160:101-104. PubMed PMID: 28704778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eradication of Helicobacter pylori infection might improve clinical status of patients with Parkinson's disease, especially on bradykinesia. AU - Liu,Huijing, AU - Su,Wen, AU - Li,Shuhua, AU - Du,Wei, AU - Ma,Xinxin, AU - Jin,Ying, AU - Li,Kai, AU - Chen,Haibo, Y1 - 2017/07/05/ PY - 2017/01/14/received PY - 2017/07/02/revised PY - 2017/07/04/accepted PY - 2017/7/14/pubmed PY - 2018/5/11/medline PY - 2017/7/14/entrez KW - Bradykinesia KW - Eradication KW - Helicobacter pylori KW - Parkinson’s disease SP - 101 EP - 104 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 160 N2 - OBJECTIVES: Previous studies have shown that Helicobacter pylori infection might make clinical status worse in patients with Parkinson's disease and Helicobacter pylori eradication might improve clinical status by modifying the pharmacokinetics of L-dopa. Here, we investigate whether Helicobacter pylori eradication could benefit idiopathic parkinsonism and Helicobacter pylori infection will effect which aspect of motor symptom significantly. PATIENTS AND METHODS: A cohort study involving idiopathic Parkinson's disease patients, screened for Helicobacter status by 13C urea breath test. Clinical status was evaluated by using the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn-Yahr stage. If patients had motor complications, they were quantified at the "on" time. The Helicobacter pylori positive patients could choose to receive Helicobacter pylori eradication or not by themselves. Group 1 was Helicobacter pylori negative patients. Group 2 was Helicobacter pylori positive patients who didn't receive eradication treatment. Group 3 was Helicobacter pylori positive patients who received successful eradication treatment. Repeat clinical assessments and 13C urea breath test was performed at 1year later. Numerical data were expressed as mean±standard deviation (SD) RESULTS: Ninety-four consecutive patients with Parkinson's disease were recruited and underwent the initial 13C urea breath test, but only forty-eight patients successfully completed the total study. In Group 3, the UPDRS-III scores (=Motor Examination Section Scores) were significantly lower 1year later compared to baseline (18.3±8.38 vs. 25.9±8.37, P=0.007). The differences were main in UPDRS-23 (=Finger Taps) (1.7±1.16 vs. 2.4±1.51, P=0.045), UPDRS-25 (Rapid Alternation Movements of Hands) (1.6±1.35 vs. 2.4±1.71, P=0.031) and UPDRS-26 (=Leg Agility) (1.3±1.25 vs.2.1±0.99, P=0.011). There was difference among three groups in the UPDRS-26 (P=0.040) of clinical status change of one year. CONCLUSION: The eradication of Helicobacter might improve the clinical status of idiopathic parkinsonism, especially on bradykinesia. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/28704778/Eradication_of_Helicobacter_pylori_infection_might_improve_clinical_status_of_patients_with_Parkinson's_disease_especially_on_bradykinesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(17)30198-1 DB - PRIME DP - Unbound Medicine ER -