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Plasma somatostatin is elevated in primary hypothyroidism compared with hyperthyroidism.
Acta Endocrinol (Copenh). 1986 Mar; 111(3):331-5.AE

Abstract

Increased pancreatic somatostatin (somatotrophin release inhibiting factor (SRIF) has been found in hypothyroid rats. Therefore, we wanted to investigate plasma SRIF in patients with hypo- and hyperthyroidism. Two groups of patients, 7 cases with autoimmune hypothyroidism, 31-75 years old, and 7 cases with Graves' disease, 19-43 years old, were compared with regard to plasma SRIF before, during and after an arginine infusion (0.5 g/kg/20 min). None of the patients suffered from diabetes mellitus or obesity. Plasma SRIF was higher in the hypothyroid patients (mean basal value 21.5 +/- 3.9, peak value 28.7 +/- 5.1 pmol/l) compared with the hyperthyroid group (mean basal value 11.6 +/- 3.3, peak value 16.2 +/- 4.0 pmol/l). The hypothyroid group also had significantly higher serum insulin values during arginine stimulation. No difference was found in plasma glucagon, serum growth hormone (GH) or blood glucose. In conclusion, plasma SRIF is elevated in primary hypothyroidism compared with hyperthyroidism. The reason for this finding is uncertain, but a reduced SRIF clearance is a possible explanation. The association of our findings with the reduced glucose tolerance in hyperthyroidism is discussed.

Authors

Skare S
No affiliation info available
Hanssen KF
No affiliation info available
Norman N
No affiliation info available

MeSH

AdultAgedBlood GlucoseFemaleGlucagonGraves DiseaseHumansHyperthyroidismHypothyroidismInsulinMaleMiddle AgedMyxedemaSomatostatinThyroiditis, Autoimmune

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2870598

Citation

Skare, S, et al. "Plasma Somatostatin Is Elevated in Primary Hypothyroidism Compared With Hyperthyroidism." Acta Endocrinologica, vol. 111, no. 3, 1986, pp. 331-5.
Skare S, Hanssen KF, Norman N. Plasma somatostatin is elevated in primary hypothyroidism compared with hyperthyroidism. Acta Endocrinol (Copenh). 1986;111(3):331-5.
Skare, S., Hanssen, K. F., & Norman, N. (1986). Plasma somatostatin is elevated in primary hypothyroidism compared with hyperthyroidism. Acta Endocrinologica, 111(3), 331-5.
Skare S, Hanssen KF, Norman N. Plasma Somatostatin Is Elevated in Primary Hypothyroidism Compared With Hyperthyroidism. Acta Endocrinol (Copenh). 1986;111(3):331-5. PubMed PMID: 2870598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma somatostatin is elevated in primary hypothyroidism compared with hyperthyroidism. AU - Skare,S, AU - Hanssen,K F, AU - Norman,N, PY - 1986/3/1/pubmed PY - 1986/3/1/medline PY - 1986/3/1/entrez SP - 331 EP - 5 JF - Acta endocrinologica JO - Acta Endocrinol (Copenh) VL - 111 IS - 3 N2 - Increased pancreatic somatostatin (somatotrophin release inhibiting factor (SRIF) has been found in hypothyroid rats. Therefore, we wanted to investigate plasma SRIF in patients with hypo- and hyperthyroidism. Two groups of patients, 7 cases with autoimmune hypothyroidism, 31-75 years old, and 7 cases with Graves' disease, 19-43 years old, were compared with regard to plasma SRIF before, during and after an arginine infusion (0.5 g/kg/20 min). None of the patients suffered from diabetes mellitus or obesity. Plasma SRIF was higher in the hypothyroid patients (mean basal value 21.5 +/- 3.9, peak value 28.7 +/- 5.1 pmol/l) compared with the hyperthyroid group (mean basal value 11.6 +/- 3.3, peak value 16.2 +/- 4.0 pmol/l). The hypothyroid group also had significantly higher serum insulin values during arginine stimulation. No difference was found in plasma glucagon, serum growth hormone (GH) or blood glucose. In conclusion, plasma SRIF is elevated in primary hypothyroidism compared with hyperthyroidism. The reason for this finding is uncertain, but a reduced SRIF clearance is a possible explanation. The association of our findings with the reduced glucose tolerance in hyperthyroidism is discussed. SN - 0001-5598 UR - https://www.unboundmedicine.com/medline/citation/2870598/Plasma_somatostatin_is_elevated_in_primary_hypothyroidism_compared_with_hyperthyroidism_ DB - PRIME DP - Unbound Medicine ER -