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Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association.
Oxid Med Cell Longev 2017; 2017:6101254OM

Abstract

PURPOSE

This study was aimed at evaluating sirtuin 4 (Sirt4) levels in obese individuals, in relation to their adherence to the Mediterranean diet (MD), a healthy dietary pattern characterized by high antioxidant capacity, and markers of visceral fat storage.

SUBJECTS/METHODS

Forty-three obese patients (44% males; BMI: 36.7-58.8 kg/m2) were consecutively included. PREvención con DIeta MEDiterránea (PREDIMED) and the 7-day food records were used to assess the adherence to MD and dietary pattern, respectively. Visceral adiposity index (VAI) was calculated. Sirt4 levels were detected by ELISA method.

RESULTS

The majority of the obese participants (62.8%) had an average adherence to MD. Compared with average adherers, low adherers had higher BMI, energy intake, and percentage of energy from lipids, mainly saturated fat and polyunsaturated fatty acids (PUFA), and lower Sirt4 levels. After adjusting for BMI, Sirt4 levels remained negatively correlated with VAI. After adjusting for total energy intake, Sirt4 levels remained negatively associated with PREDIMED and consumption of n-3 PUFA, vitamins C and E. The threshold value of PREDIMED predicting the lowest decrease in Sirt4 levels was found at a score of 6.

CONCLUSIONS

Less reduced Sirt4 levels in obese patients adhering to MD suggest a further aspect of the antioxidant advantage of MD.

Authors+Show Affiliations

I.O.S. & COLEMAN Srl, Acerra, 80011 Naples, Italy.Dipartimento di Medicina Clinica e Chirurgia, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.IRCCS SDN, Napoli Via Gianturco 113, 80143 Naples, Italy.I.O.S. & COLEMAN Srl, Acerra, 80011 Naples, Italy.Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.I.O.S. & COLEMAN Srl, Acerra, 80011 Naples, Italy.Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28706576

Citation

Barrea, Luigi, et al. "Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: a Novel Association." Oxidative Medicine and Cellular Longevity, vol. 2017, 2017, p. 6101254.
Barrea L, Tarantino G, Somma CD, et al. Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association. Oxid Med Cell Longev. 2017;2017:6101254.
Barrea, L., Tarantino, G., Somma, C. D., Muscogiuri, G., Macchia, P. E., Falco, A., ... Savastano, S. (2017). Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association. Oxidative Medicine and Cellular Longevity, 2017, p. 6101254. doi:10.1155/2017/6101254.
Barrea L, et al. Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: a Novel Association. Oxid Med Cell Longev. 2017;2017:6101254. PubMed PMID: 28706576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association. AU - Barrea,Luigi, AU - Tarantino,Giovanni, AU - Somma,Carolina Di, AU - Muscogiuri,Giovanna, AU - Macchia,Paolo Emidio, AU - Falco,Andrea, AU - Colao,Annamaria, AU - Savastano,Silvia, Y1 - 2017/06/15/ PY - 2016/12/06/received PY - 2017/03/16/accepted PY - 2017/7/15/entrez PY - 2017/7/15/pubmed PY - 2018/4/11/medline SP - 6101254 EP - 6101254 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2017 N2 - PURPOSE: This study was aimed at evaluating sirtuin 4 (Sirt4) levels in obese individuals, in relation to their adherence to the Mediterranean diet (MD), a healthy dietary pattern characterized by high antioxidant capacity, and markers of visceral fat storage. SUBJECTS/METHODS: Forty-three obese patients (44% males; BMI: 36.7-58.8 kg/m2) were consecutively included. PREvención con DIeta MEDiterránea (PREDIMED) and the 7-day food records were used to assess the adherence to MD and dietary pattern, respectively. Visceral adiposity index (VAI) was calculated. Sirt4 levels were detected by ELISA method. RESULTS: The majority of the obese participants (62.8%) had an average adherence to MD. Compared with average adherers, low adherers had higher BMI, energy intake, and percentage of energy from lipids, mainly saturated fat and polyunsaturated fatty acids (PUFA), and lower Sirt4 levels. After adjusting for BMI, Sirt4 levels remained negatively correlated with VAI. After adjusting for total energy intake, Sirt4 levels remained negatively associated with PREDIMED and consumption of n-3 PUFA, vitamins C and E. The threshold value of PREDIMED predicting the lowest decrease in Sirt4 levels was found at a score of 6. CONCLUSIONS: Less reduced Sirt4 levels in obese patients adhering to MD suggest a further aspect of the antioxidant advantage of MD. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/28706576/Adherence_to_the_Mediterranean_Diet_and_Circulating_Levels_of_Sirtuin_4_in_Obese_Patients:_A_Novel_Association_ L2 - https://dx.doi.org/10.1155/2017/6101254 DB - PRIME DP - Unbound Medicine ER -