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Development of a membrane of poly (L-co-D,L lactic acid-co-trimethylene carbonate) with aloe vera: An alternative biomaterial designed to improve skin healing.
J Biomater Appl. 2017 09; 32(3):311-320.JB

Abstract

The search for new therapies and drugs that act as topical agents to relieve pain and control the infectious processes in burns always attracted interest in clinical trials. As an alternative to synthetic drugs, the use of natural extracts is useful in the development of new strategies and formulations for improving the life quality. The aim of this study was to develop a wound dressing using Poly(L-co-D,L lactic acid-co-TMC) (PLDLA-co-TMC) containing aloe vera (AV). This natural plant extract is known for its modulatory effects under healing process. The membrane of PLDLA-co-TMC+aloe vera was prepared at different concentrations of AV (5, 10, 15 and 50%). The FTIR showed no change in the PLDLA-co-TMC spectrum after AV addition, while the swelling test showed changes only in PLDLA-co-TMC+AV at 50%. The wettability measurements showed decrease in the contact angle in all samples after the AV addition in the polymer, while the AV release test showed that PLDLA-co-TMC+50%AV sample has higher AV release rate than the sample with other AV concentrations. The SEM analysis showed that AV was homogeneously distributed at 5% only. Tensile tests demonstrated an increase in the Young's modulus and a reduction in the elongation till rupture of the PLDLA-co-TMC after the addition of AV. Biocompatibility in vitro evaluation with fibroblast cells seeded in the membranes of PLDLA-co-TMC+AV showed that the cells were able to adhere, proliferate and maintain mitochondrial activity in all AV concentrations tested. Due to the known skin medicinal properties attributed to AV and the results here obtained, we suggest that after in vivo trials, the PLDLA-co-TMC+AV should be a promising biomaterial for application as a device for skin curative and healing agent.

Authors+Show Affiliations

1 Faculdade de Ciencias Medicas e da Saude, Pontificia Universidade Catolica de Sao Paulo, São Paulo, Brazil.2 Universidade Estadual de Campinas Instituto de Biologia, São Paulo, Brazil.1 Faculdade de Ciencias Medicas e da Saude, Pontificia Universidade Catolica de Sao Paulo, São Paulo, Brazil.2 Universidade Estadual de Campinas Instituto de Biologia, São Paulo, Brazil.1 Faculdade de Ciencias Medicas e da Saude, Pontificia Universidade Catolica de Sao Paulo, São Paulo, Brazil.1 Faculdade de Ciencias Medicas e da Saude, Pontificia Universidade Catolica de Sao Paulo, São Paulo, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28707999

Citation

Komatsu, Daniel, et al. "Development of a Membrane of Poly (L-co-D,L Lactic Acid-co-trimethylene Carbonate) With Aloe Vera: an Alternative Biomaterial Designed to Improve Skin Healing." Journal of Biomaterials Applications, vol. 32, no. 3, 2017, pp. 311-320.
Komatsu D, Mistura DV, Motta A, et al. Development of a membrane of poly (L-co-D,L lactic acid-co-trimethylene carbonate) with aloe vera: An alternative biomaterial designed to improve skin healing. J Biomater Appl. 2017;32(3):311-320.
Komatsu, D., Mistura, D. V., Motta, A., Domingues, J. A., Hausen, M. A., & Duek, E. (2017). Development of a membrane of poly (L-co-D,L lactic acid-co-trimethylene carbonate) with aloe vera: An alternative biomaterial designed to improve skin healing. Journal of Biomaterials Applications, 32(3), 311-320. https://doi.org/10.1177/0885328217719854
Komatsu D, et al. Development of a Membrane of Poly (L-co-D,L Lactic Acid-co-trimethylene Carbonate) With Aloe Vera: an Alternative Biomaterial Designed to Improve Skin Healing. J Biomater Appl. 2017;32(3):311-320. PubMed PMID: 28707999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of a membrane of poly (L-co-D,L lactic acid-co-trimethylene carbonate) with aloe vera: An alternative biomaterial designed to improve skin healing. AU - Komatsu,Daniel, AU - Mistura,Daniel V, AU - Motta,Adriana, AU - Domingues,Juliana A, AU - Hausen,Moema A, AU - Duek,Eliana, Y1 - 2017/07/14/ PY - 2017/7/15/pubmed PY - 2018/5/8/medline PY - 2017/7/15/entrez KW - Bioreabsorbable polymers KW - L lactic acid-co-trimethylene carbonate) KW - aloe vera KW - curative KW - poly (L-co-D KW - wound healing SP - 311 EP - 320 JF - Journal of biomaterials applications JO - J Biomater Appl VL - 32 IS - 3 N2 - The search for new therapies and drugs that act as topical agents to relieve pain and control the infectious processes in burns always attracted interest in clinical trials. As an alternative to synthetic drugs, the use of natural extracts is useful in the development of new strategies and formulations for improving the life quality. The aim of this study was to develop a wound dressing using Poly(L-co-D,L lactic acid-co-TMC) (PLDLA-co-TMC) containing aloe vera (AV). This natural plant extract is known for its modulatory effects under healing process. The membrane of PLDLA-co-TMC+aloe vera was prepared at different concentrations of AV (5, 10, 15 and 50%). The FTIR showed no change in the PLDLA-co-TMC spectrum after AV addition, while the swelling test showed changes only in PLDLA-co-TMC+AV at 50%. The wettability measurements showed decrease in the contact angle in all samples after the AV addition in the polymer, while the AV release test showed that PLDLA-co-TMC+50%AV sample has higher AV release rate than the sample with other AV concentrations. The SEM analysis showed that AV was homogeneously distributed at 5% only. Tensile tests demonstrated an increase in the Young's modulus and a reduction in the elongation till rupture of the PLDLA-co-TMC after the addition of AV. Biocompatibility in vitro evaluation with fibroblast cells seeded in the membranes of PLDLA-co-TMC+AV showed that the cells were able to adhere, proliferate and maintain mitochondrial activity in all AV concentrations tested. Due to the known skin medicinal properties attributed to AV and the results here obtained, we suggest that after in vivo trials, the PLDLA-co-TMC+AV should be a promising biomaterial for application as a device for skin curative and healing agent. SN - 1530-8022 UR - https://www.unboundmedicine.com/medline/citation/28707999/Development_of_a_membrane_of_poly_(L-co-D,L_lactic_acid-co-trimethylene_carbonate)_with_aloe_vera:_An_alternative_biomaterial_designed_to_improve_skin_healing L2 - http://journals.sagepub.com/doi/full/10.1177/0885328217719854?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -