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Pharmacokinetics of delta 9-tetrahydrocannabinol in rabbits following single or multiple intravenous doses.
Drug Metab Dispos. 1986 Mar-Apr; 14(2):230-8.DM

Abstract

The pharmacokinetics of delta 9-tetrahydrocannabinol (delta 9-THC) has been studied in rabbits under conditions of single or multiple administration. Measurement of the drug was by a sensitive GC/MS technique using metastable ion monitoring and capable of measuring 0.005 ng/ml of the drug in plasma. This method enabled measurements of the drug to be made for 8-10 days after a single iv dose of 1 mg/kg of delta 9-THC and for 26 days following treatment for 22 days with the same dose. Plasma concentration-time data were analyzed by least squares nonlinear regression with the program NONLIN and terminal half-lives in the range 30-66 hr [mean 47.1 +/- 3.5 (SE), n = 8] were found after acute drug treatment. These increased to 74.6 +/- 1.7 hr (n = 4) after an 8-day treatment and to 83.0 hr after the 22-day treatment. Plasma clearance values were high, but the large amount of drug sequestered in tissues, reflected by large volumes of distribution, was the main determinant of terminal half-life. Measurements of the drug in several tissues indicated that fat was the major site of sequestration. The relative concentrations of delta 9-THC in the various tissues were similar to those observed for other lipophilic compounds, suggesting that distribution of delta 9-THC is governed by its physicochemical properties and not by any active transport process or specific barriers.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2870899

Citation

Leuschner, J T., et al. "Pharmacokinetics of Delta 9-tetrahydrocannabinol in Rabbits Following Single or Multiple Intravenous Doses." Drug Metabolism and Disposition: the Biological Fate of Chemicals, vol. 14, no. 2, 1986, pp. 230-8.
Leuschner JT, Harvey DJ, Bullingham RE, et al. Pharmacokinetics of delta 9-tetrahydrocannabinol in rabbits following single or multiple intravenous doses. Drug Metab Dispos. 1986;14(2):230-8.
Leuschner, J. T., Harvey, D. J., Bullingham, R. E., & Paton, W. D. (1986). Pharmacokinetics of delta 9-tetrahydrocannabinol in rabbits following single or multiple intravenous doses. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 14(2), 230-8.
Leuschner JT, et al. Pharmacokinetics of Delta 9-tetrahydrocannabinol in Rabbits Following Single or Multiple Intravenous Doses. Drug Metab Dispos. 1986 Mar-Apr;14(2):230-8. PubMed PMID: 2870899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of delta 9-tetrahydrocannabinol in rabbits following single or multiple intravenous doses. AU - Leuschner,J T, AU - Harvey,D J, AU - Bullingham,R E, AU - Paton,W D, PY - 1986/3/1/pubmed PY - 1986/3/1/medline PY - 1986/3/1/entrez SP - 230 EP - 8 JF - Drug metabolism and disposition: the biological fate of chemicals JO - Drug Metab Dispos VL - 14 IS - 2 N2 - The pharmacokinetics of delta 9-tetrahydrocannabinol (delta 9-THC) has been studied in rabbits under conditions of single or multiple administration. Measurement of the drug was by a sensitive GC/MS technique using metastable ion monitoring and capable of measuring 0.005 ng/ml of the drug in plasma. This method enabled measurements of the drug to be made for 8-10 days after a single iv dose of 1 mg/kg of delta 9-THC and for 26 days following treatment for 22 days with the same dose. Plasma concentration-time data were analyzed by least squares nonlinear regression with the program NONLIN and terminal half-lives in the range 30-66 hr [mean 47.1 +/- 3.5 (SE), n = 8] were found after acute drug treatment. These increased to 74.6 +/- 1.7 hr (n = 4) after an 8-day treatment and to 83.0 hr after the 22-day treatment. Plasma clearance values were high, but the large amount of drug sequestered in tissues, reflected by large volumes of distribution, was the main determinant of terminal half-life. Measurements of the drug in several tissues indicated that fat was the major site of sequestration. The relative concentrations of delta 9-THC in the various tissues were similar to those observed for other lipophilic compounds, suggesting that distribution of delta 9-THC is governed by its physicochemical properties and not by any active transport process or specific barriers. SN - 0090-9556 UR - https://www.unboundmedicine.com/medline/citation/2870899/Pharmacokinetics_of_delta_9_tetrahydrocannabinol_in_rabbits_following_single_or_multiple_intravenous_doses_ L2 - http://dmd.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2870899 DB - PRIME DP - Unbound Medicine ER -