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Hybrid smoothed dissipative particle dynamics and immersed boundary method for simulation of red blood cells in flows.
Phys Rev E 2017; 95(6-1):063314PR

Abstract

In biofluid flow systems, often the flow problems of fluids of complex structures, such as the flow of red blood cells (RBCs) through complex capillary vessels, need to be considered. The smoothed dissipative particle dynamics (SDPD), a particle-based method, is one of the easy and flexible methods to model such complex structure fluids. It couples the best features of the smoothed particle hydrodynamics (SPH) and dissipative particle dynamics (DPD), with parameters having specific physical meaning (coming from SPH discretization of the Navier-Stokes equations), combined with thermal fluctuations in a mesoscale simulation, in a similar manner to the DPD. On the other hand, the immersed boundary method (IBM), a preferred method for handling fluid-structure interaction problems, has also been widely used to handle the fluid-RBC interaction in RBC simulations. In this paper, we aim to couple SDPD and IBM together to carry out the simulations of RBCs in complex flow problems. First, we develop the SDPD-IBM model in details, including the SDPD model for the evolving fluid flow, the RBC model for calculating RBC deformation force, the IBM for treating fluid-RBC interaction, and the solid boundary treatment model as well. We then conduct the verification and validation of the combined SDPD-IBM method. Finally, we demonstrate the capability of the SDPD-IBM method by simulating the flows of RBCs in rectangular, cylinder, curved, bifurcated, and constricted tubes, respectively.

Authors+Show Affiliations

Department of Computational Mathematics, Jilin University, Changchun, Jilin 130012, China.Department of Mechanical Engineering, National University of Singapore, Singapore 117583.Department of Biomedical Engineering, National University of Singapore, Singapore 117581. Mechanobiology Institute, National University of Singapore, Singapore 117411.Department of Computational Mathematics, Jilin University, Changchun, Jilin 130012, China. Department of Mechanical Engineering, National University of Singapore, Singapore 117583. Department of Biomedical Engineering, National University of Singapore, Singapore 117581. Mechanobiology Institute, National University of Singapore, Singapore 117411.Department of Computational Mathematics, Jilin University, Changchun, Jilin 130012, China. Department of Mechanical Engineering, National University of Singapore, Singapore 117583. Department of Biomedical Engineering, National University of Singapore, Singapore 117581. Mechanobiology Institute, National University of Singapore, Singapore 117411.

Pub Type(s)

Journal Article
Validation Studies

Language

eng

PubMed ID

28709282

Citation

Ye, Ting, et al. "Hybrid Smoothed Dissipative Particle Dynamics and Immersed Boundary Method for Simulation of Red Blood Cells in Flows." Physical Review. E, vol. 95, no. 6-1, 2017, p. 063314.
Ye T, Phan-Thien N, Lim CT, et al. Hybrid smoothed dissipative particle dynamics and immersed boundary method for simulation of red blood cells in flows. Phys Rev E. 2017;95(6-1):063314.
Ye, T., Phan-Thien, N., Lim, C. T., Peng, L., & Shi, H. (2017). Hybrid smoothed dissipative particle dynamics and immersed boundary method for simulation of red blood cells in flows. Physical Review. E, 95(6-1), p. 063314. doi:10.1103/PhysRevE.95.063314.
Ye T, et al. Hybrid Smoothed Dissipative Particle Dynamics and Immersed Boundary Method for Simulation of Red Blood Cells in Flows. Phys Rev E. 2017;95(6-1):063314. PubMed PMID: 28709282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hybrid smoothed dissipative particle dynamics and immersed boundary method for simulation of red blood cells in flows. AU - Ye,Ting, AU - Phan-Thien,Nhan, AU - Lim,Chwee Teck, AU - Peng,Lina, AU - Shi,Huixin, Y1 - 2017/06/26/ PY - 2017/02/28/received PY - 2017/7/16/entrez PY - 2017/7/16/pubmed PY - 2018/10/5/medline SP - 063314 EP - 063314 JF - Physical review. E JO - Phys Rev E VL - 95 IS - 6-1 N2 - In biofluid flow systems, often the flow problems of fluids of complex structures, such as the flow of red blood cells (RBCs) through complex capillary vessels, need to be considered. The smoothed dissipative particle dynamics (SDPD), a particle-based method, is one of the easy and flexible methods to model such complex structure fluids. It couples the best features of the smoothed particle hydrodynamics (SPH) and dissipative particle dynamics (DPD), with parameters having specific physical meaning (coming from SPH discretization of the Navier-Stokes equations), combined with thermal fluctuations in a mesoscale simulation, in a similar manner to the DPD. On the other hand, the immersed boundary method (IBM), a preferred method for handling fluid-structure interaction problems, has also been widely used to handle the fluid-RBC interaction in RBC simulations. In this paper, we aim to couple SDPD and IBM together to carry out the simulations of RBCs in complex flow problems. First, we develop the SDPD-IBM model in details, including the SDPD model for the evolving fluid flow, the RBC model for calculating RBC deformation force, the IBM for treating fluid-RBC interaction, and the solid boundary treatment model as well. We then conduct the verification and validation of the combined SDPD-IBM method. Finally, we demonstrate the capability of the SDPD-IBM method by simulating the flows of RBCs in rectangular, cylinder, curved, bifurcated, and constricted tubes, respectively. SN - 2470-0053 UR - https://www.unboundmedicine.com/medline/citation/28709282/Hybrid_smoothed_dissipative_particle_dynamics_and_immersed_boundary_method_for_simulation_of_red_blood_cells_in_flows_ DB - PRIME DP - Unbound Medicine ER -