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The effect of testosterone on citrate synthesis and citrate oxidation and a proposed mechanism for regulation of net citrate production in prostate.
Horm Metab Res. 1986 Mar; 18(3):177-81.HM

Abstract

Citrate oxidation by rat ventral prostate was reduced by castration and increased by testosterone administration. Similarly, the mitochondrial aconitase activity was decreased by castration; whereas cytosol aconitase was unaffected. The rate of citrate oxidation is extremely low in prostate. Castration also decreased mitochondrial aspartate aminotransferase activity while having no effect on the cytosol isoenzyme. Testosterone markedly stimulated the net production of citrate from aspartate plus glutamate by prostate mitochondria. These studies support the proposal that aspartate is a major source of oxalacetate for citrate production, and that a "glutamate-aspartate-citrate" pathway may be functional in prostate mitochondria. In addition, testosterone can regulate citrate production by a specific effect on mitochondrial aspartate aminotransferase activity. Testosterone also regulates the flux of citrate through the Krebs cycle, but this represents only a small proportion of the citrate accumulated. These conditions would be consistent with the function of prostate epithelium in accumulating and secreting citrate.

Authors

Franklin RB
No affiliation info available
Kahng MW
No affiliation info available
Akuffo V
No affiliation info available
Costello LC
No affiliation info available

MeSH

Acetyl Coenzyme AAnimalsAspartate AminotransferasesAspartic AcidCitratesCitric AcidGlutamatesGlutamic AcidMaleMitochondriaModels, BiologicalOrchiectomyOxidation-ReductionProstateRatsRats, Inbred StrainsTestisTestosterone

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2870972

Citation

Franklin, R B., et al. "The Effect of Testosterone On Citrate Synthesis and Citrate Oxidation and a Proposed Mechanism for Regulation of Net Citrate Production in Prostate." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 18, no. 3, 1986, pp. 177-81.
Franklin RB, Kahng MW, Akuffo V, et al. The effect of testosterone on citrate synthesis and citrate oxidation and a proposed mechanism for regulation of net citrate production in prostate. Horm Metab Res. 1986;18(3):177-81.
Franklin, R. B., Kahng, M. W., Akuffo, V., & Costello, L. C. (1986). The effect of testosterone on citrate synthesis and citrate oxidation and a proposed mechanism for regulation of net citrate production in prostate. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 18(3), 177-81.
Franklin RB, et al. The Effect of Testosterone On Citrate Synthesis and Citrate Oxidation and a Proposed Mechanism for Regulation of Net Citrate Production in Prostate. Horm Metab Res. 1986;18(3):177-81. PubMed PMID: 2870972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of testosterone on citrate synthesis and citrate oxidation and a proposed mechanism for regulation of net citrate production in prostate. AU - Franklin,R B, AU - Kahng,M W, AU - Akuffo,V, AU - Costello,L C, PY - 1986/3/1/pubmed PY - 1986/3/1/medline PY - 1986/3/1/entrez SP - 177 EP - 81 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 18 IS - 3 N2 - Citrate oxidation by rat ventral prostate was reduced by castration and increased by testosterone administration. Similarly, the mitochondrial aconitase activity was decreased by castration; whereas cytosol aconitase was unaffected. The rate of citrate oxidation is extremely low in prostate. Castration also decreased mitochondrial aspartate aminotransferase activity while having no effect on the cytosol isoenzyme. Testosterone markedly stimulated the net production of citrate from aspartate plus glutamate by prostate mitochondria. These studies support the proposal that aspartate is a major source of oxalacetate for citrate production, and that a "glutamate-aspartate-citrate" pathway may be functional in prostate mitochondria. In addition, testosterone can regulate citrate production by a specific effect on mitochondrial aspartate aminotransferase activity. Testosterone also regulates the flux of citrate through the Krebs cycle, but this represents only a small proportion of the citrate accumulated. These conditions would be consistent with the function of prostate epithelium in accumulating and secreting citrate. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/2870972/The_effect_of_testosterone_on_citrate_synthesis_and_citrate_oxidation_and_a_proposed_mechanism_for_regulation_of_net_citrate_production_in_prostate_ DB - PRIME DP - Unbound Medicine ER -