Tags

Type your tag names separated by a space and hit enter

MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases.
Biochem Pharmacol. 2017 10 01; 141:118-131.BP

Abstract

MicroRNAs (miRNA) are small non-coding molecules that revolutionized our knowledge about the regulation of gene expression. Capable to target a large number of mRNA, miRNA are thought to regulate around 30% of the entire human genome. Therefore, these molecules are able to regulate several biological processes, including neuronal survival, differentiation and regeneration. Additionally, miRNA might act as valuable clinical agents in brain pathological conditions. Their specific expression patterns in the brain parenchyma and/or in circulating fluids have been highlighted as potential biomarkers, while the modulation of their activity may have therapeutic value for several neurodegenerative diseases. In this review, we describe miRNA biogenesis, signaling and regulation as well as the role of miR-9, miR-124, miR-132 and miR-137 in both adult neurogenesis and neurodegeneration, namely in Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. The relationship between miRNA, neurodegeneration and neurogenesis will be highlighted. Moreover, the benefits, outcomes and limitations of therapies using miRNA technology for neurodegenerative disorders will also be discussed.

Authors+Show Affiliations

Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal. Electronic address: libernardino@fcsaude.ubi.pt.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28709951

Citation

Saraiva, Cláudia, et al. "MicroRNA: Basic Concepts and Implications for Regeneration and Repair of Neurodegenerative Diseases." Biochemical Pharmacology, vol. 141, 2017, pp. 118-131.
Saraiva C, Esteves M, Bernardino L. MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases. Biochem Pharmacol. 2017;141:118-131.
Saraiva, C., Esteves, M., & Bernardino, L. (2017). MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases. Biochemical Pharmacology, 141, 118-131. https://doi.org/10.1016/j.bcp.2017.07.008
Saraiva C, Esteves M, Bernardino L. MicroRNA: Basic Concepts and Implications for Regeneration and Repair of Neurodegenerative Diseases. Biochem Pharmacol. 2017 10 1;141:118-131. PubMed PMID: 28709951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases. AU - Saraiva,Cláudia, AU - Esteves,Marta, AU - Bernardino,Liliana, Y1 - 2017/07/11/ PY - 2017/04/13/received PY - 2017/07/07/accepted PY - 2017/7/16/pubmed PY - 2017/10/4/medline PY - 2017/7/16/entrez KW - Neurodegeneration KW - Neurogenesis KW - Regeneration KW - miRNA KW - miRNA-based therapies SP - 118 EP - 131 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 141 N2 - MicroRNAs (miRNA) are small non-coding molecules that revolutionized our knowledge about the regulation of gene expression. Capable to target a large number of mRNA, miRNA are thought to regulate around 30% of the entire human genome. Therefore, these molecules are able to regulate several biological processes, including neuronal survival, differentiation and regeneration. Additionally, miRNA might act as valuable clinical agents in brain pathological conditions. Their specific expression patterns in the brain parenchyma and/or in circulating fluids have been highlighted as potential biomarkers, while the modulation of their activity may have therapeutic value for several neurodegenerative diseases. In this review, we describe miRNA biogenesis, signaling and regulation as well as the role of miR-9, miR-124, miR-132 and miR-137 in both adult neurogenesis and neurodegeneration, namely in Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. The relationship between miRNA, neurodegeneration and neurogenesis will be highlighted. Moreover, the benefits, outcomes and limitations of therapies using miRNA technology for neurodegenerative disorders will also be discussed. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/28709951/MicroRNA:_Basic_concepts_and_implications_for_regeneration_and_repair_of_neurodegenerative_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(17)30485-9 DB - PRIME DP - Unbound Medicine ER -