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Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project.
Osteoarthritis Cartilage. 2017 10; 25(10):1672-1679.OC

Abstract

OBJECTIVE

To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA.

DESIGN

A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels were graded by severity (OST and DSN) and presence (FOA) of degeneration. Biomarkers included hyaluronan (HA) and type II collagen (CTX-II). Adjusted risk ratios (aRRR) were estimated using multinomial regression, with adjustment for age, race, sex, body mass index (BMI), and radiographic OA (knee, hip, hand). Interactions were tested between sex, race and low back symptoms.

RESULTS

FOA only was present in 22.4%, 14.5% had spine OA only, and 34.6% had the combination of FOA and spine OA. Compared to the reference group of neither FOA or spine OA, a one unit higher ln HA level was associated with 31% higher relative risk ratio (RRR = 1.31 (95% 1.03, 1.67)) of having FOA only, while, a one unit higher lnuCTX-II level was associated with 84% higher relative risk ratio (RRR = 1.84 (95% CI 1.19, 2.84)) of having spine OA only. No significant interactions were identified.

CONCLUSION

Interestingly, OA affecting the synovial facet joint was associated with a marker of inflammation (HA). Spine OA, affecting intervertebral discs that contain collagen type II, was associated with a marker reflecting collagen type II degradation (CTX-II). These findings suggest that biomarkers may reflect the different pathophysiologic processes of lumbar spine OA phenotypes.

Authors+Show Affiliations

Department of Orthopedic Surgery, Duke Clinical Research Institute, Duke University School of Medicine, USA. Electronic address: adam.goode@duke.edu.Department of Medicine, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, USA.Duke Molecular Physiology Institute and Division of Rheumatology, Duke University School of Medicine, Durham, NC, USA.Thurston Arthritis Research Center, Department of Radiology, University of North Carolina, Chapel Hill, USA.Department of Medicine, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28711584

Citation

Goode, A P., et al. "Biomarkers Reflect Differences in Osteoarthritis Phenotypes of the Lumbar Spine: the Johnston County Osteoarthritis Project." Osteoarthritis and Cartilage, vol. 25, no. 10, 2017, pp. 1672-1679.
Goode AP, Nelson AE, Kraus VB, et al. Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2017;25(10):1672-1679.
Goode, A. P., Nelson, A. E., Kraus, V. B., Renner, J. B., & Jordan, J. M. (2017). Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project. Osteoarthritis and Cartilage, 25(10), 1672-1679. https://doi.org/10.1016/j.joca.2017.07.007
Goode AP, et al. Biomarkers Reflect Differences in Osteoarthritis Phenotypes of the Lumbar Spine: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2017;25(10):1672-1679. PubMed PMID: 28711584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project. AU - Goode,A P, AU - Nelson,A E, AU - Kraus,V B, AU - Renner,J B, AU - Jordan,J M, Y1 - 2017/07/12/ PY - 2016/11/02/received PY - 2017/06/02/revised PY - 2017/07/05/accepted PY - 2017/7/18/pubmed PY - 2018/7/19/medline PY - 2017/7/17/entrez KW - Biomarkers KW - Lumbar spine KW - Osteoarthritis KW - Phenotypes SP - 1672 EP - 1679 JF - Osteoarthritis and cartilage JO - Osteoarthritis Cartilage VL - 25 IS - 10 N2 - OBJECTIVE: To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA. DESIGN: A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels were graded by severity (OST and DSN) and presence (FOA) of degeneration. Biomarkers included hyaluronan (HA) and type II collagen (CTX-II). Adjusted risk ratios (aRRR) were estimated using multinomial regression, with adjustment for age, race, sex, body mass index (BMI), and radiographic OA (knee, hip, hand). Interactions were tested between sex, race and low back symptoms. RESULTS: FOA only was present in 22.4%, 14.5% had spine OA only, and 34.6% had the combination of FOA and spine OA. Compared to the reference group of neither FOA or spine OA, a one unit higher ln HA level was associated with 31% higher relative risk ratio (RRR = 1.31 (95% 1.03, 1.67)) of having FOA only, while, a one unit higher lnuCTX-II level was associated with 84% higher relative risk ratio (RRR = 1.84 (95% CI 1.19, 2.84)) of having spine OA only. No significant interactions were identified. CONCLUSION: Interestingly, OA affecting the synovial facet joint was associated with a marker of inflammation (HA). Spine OA, affecting intervertebral discs that contain collagen type II, was associated with a marker reflecting collagen type II degradation (CTX-II). These findings suggest that biomarkers may reflect the different pathophysiologic processes of lumbar spine OA phenotypes. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/28711584/Biomarkers_reflect_differences_in_osteoarthritis_phenotypes_of_the_lumbar_spine:_the_Johnston_County_Osteoarthritis_Project_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1063-4584(17)31086-5 DB - PRIME DP - Unbound Medicine ER -