Tags

Type your tag names separated by a space and hit enter

The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis.
J Am Dent Assoc. 2017 10; 148(10):743-749.e9.JA

Abstract

BACKGROUND

The relationship between levels of salivary and serum interleukin (IL)-6 and oral lichen planus (OLP) is not understood fully. The authors conducted a systematic review and meta-analysis to compare levels of salivary and serum IL-6 among people with OLP and healthy control participants.

METHODS

The authors searched the literature for studies whose investigators had evaluated the relationships between IL-6 and OLP before treatment. The authors used meta-analysis to compare the standardized mean differences (SMD) of the levels of salivary and serum IL-6 between people who had OLP and people who did not have OLP and between patients with erosive OLP and patients with nonerosive OLP.

RESULTS

The results of separate meta-analyses, which included 5 studies each, indicated that the levels of salivary and serum IL-6 were significantly higher among patients with OLP than among healthy control participants (SMD, 2.35; 95% confidence interval [CI], 0.50 to 4.19; P = .01; and SMD, 2.03; 95% CI, 0.74 to 3.33; P = .002; respectively). The results of a meta-analysis of 4 studies indicated that the levels of IL-6 were not significantly different between patients with erosive OLP and patients with nonerosive OLP (SMD, 1.37; 95% CI, -0.26 to 3.00; P = .10). There was significant heterogeneity among the studies (P < .00001).

CONCLUSIONS

Through the results of this meta-analysis, the authors found significant differences in the levels of IL-6 in saliva and serum between patients with OLP and healthy control participants. The authors found no differences in the levels of serum IL-6 between patients with erosive OLP and patients with nonerosive OLP. These results should be considered with caution because there was a high degree of heterogeneity among studies.

PRACTICAL IMPLICATIONS

Levels of IL-6 in saliva and serum may be potential biomarkers for OLP. However, additional research is needed to confirm findings of this meta-analysis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

28712412

Citation

Liu, Jinglong, et al. "The Relationship Between Levels of Salivary and Serum Interleukin-6 and Oral Lichen Planus: a Systematic Review and Meta-analysis." Journal of the American Dental Association (1939), vol. 148, no. 10, 2017, pp. 743-749.e9.
Liu J, Shi Q, Yang S, et al. The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis. J Am Dent Assoc. 2017;148(10):743-749.e9.
Liu, J., Shi, Q., Yang, S., Wang, Q., Xu, J., & Guo, B. (2017). The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis. Journal of the American Dental Association (1939), 148(10), 743-e9. https://doi.org/10.1016/j.adaj.2017.05.007
Liu J, et al. The Relationship Between Levels of Salivary and Serum Interleukin-6 and Oral Lichen Planus: a Systematic Review and Meta-analysis. J Am Dent Assoc. 2017;148(10):743-749.e9. PubMed PMID: 28712412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis. AU - Liu,Jinglong, AU - Shi,Quan, AU - Yang,Shuo, AU - Wang,Qianxin, AU - Xu,Juan, AU - Guo,Bin, Y1 - 2017/07/13/ PY - 2017/02/17/received PY - 2017/05/04/revised PY - 2017/05/10/accepted PY - 2017/7/18/pubmed PY - 2018/10/20/medline PY - 2017/7/18/entrez KW - Oral lichen planus KW - interleukins KW - oral diagnosis SP - 743 EP - 749.e9 JF - Journal of the American Dental Association (1939) JO - J Am Dent Assoc VL - 148 IS - 10 N2 - BACKGROUND: The relationship between levels of salivary and serum interleukin (IL)-6 and oral lichen planus (OLP) is not understood fully. The authors conducted a systematic review and meta-analysis to compare levels of salivary and serum IL-6 among people with OLP and healthy control participants. METHODS: The authors searched the literature for studies whose investigators had evaluated the relationships between IL-6 and OLP before treatment. The authors used meta-analysis to compare the standardized mean differences (SMD) of the levels of salivary and serum IL-6 between people who had OLP and people who did not have OLP and between patients with erosive OLP and patients with nonerosive OLP. RESULTS: The results of separate meta-analyses, which included 5 studies each, indicated that the levels of salivary and serum IL-6 were significantly higher among patients with OLP than among healthy control participants (SMD, 2.35; 95% confidence interval [CI], 0.50 to 4.19; P = .01; and SMD, 2.03; 95% CI, 0.74 to 3.33; P = .002; respectively). The results of a meta-analysis of 4 studies indicated that the levels of IL-6 were not significantly different between patients with erosive OLP and patients with nonerosive OLP (SMD, 1.37; 95% CI, -0.26 to 3.00; P = .10). There was significant heterogeneity among the studies (P < .00001). CONCLUSIONS: Through the results of this meta-analysis, the authors found significant differences in the levels of IL-6 in saliva and serum between patients with OLP and healthy control participants. The authors found no differences in the levels of serum IL-6 between patients with erosive OLP and patients with nonerosive OLP. These results should be considered with caution because there was a high degree of heterogeneity among studies. PRACTICAL IMPLICATIONS: Levels of IL-6 in saliva and serum may be potential biomarkers for OLP. However, additional research is needed to confirm findings of this meta-analysis. SN - 1943-4723 UR - https://www.unboundmedicine.com/medline/citation/28712412/The_relationship_between_levels_of_salivary_and_serum_interleukin_6_and_oral_lichen_planus:_A_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.