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Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma.
Sci Rep. 2017 07 17; 7(1):5543.SR

Abstract

Glaucoma is a disease characterized by pathologic changes in inner retinal layers, which are comprised of retinal ganglion cells (RGCs). As retinal ganglion cells (RGCs) cross over other retinal neurons that are connected by synapses, it is meaningful to investigate the outer retinal changes in glaucoma. We evaluated the association between thicknesses of segmented retinal layers in macular region and severity of visual field loss in open-angle glaucoma (OAG). This study involved 103 glaucomatous eyes. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL) thicknesses were measured at the macular level using the Spectral-domain optical coherence tomography with segmentation software. The functional losses were measured using 24-2 standard automated perimetry. Macular structure losses were positively correlated with functional loss for RNFL, GCL, and IPL (R = 0.550, 0.637, and 0.649, respectively, P < 0.001) and negatively correlated with INL (R = -0.295, P = 0.041). By multivariate regression analysis, INL thickness was significantly associated with visual field mean deviation (dB) and optic disc hemorrhage. These finding carefully suggest reactive responses of neuronal or glial cells located in the INL occur during glaucoma progression.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. ckpark@catholic.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28717139

Citation

Kim, Eun Kyoung, et al. "Relationship Between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma." Scientific Reports, vol. 7, no. 1, 2017, p. 5543.
Kim EK, Park HL, Park CK. Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma. Sci Rep. 2017;7(1):5543.
Kim, E. K., Park, H. L., & Park, C. K. (2017). Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma. Scientific Reports, 7(1), 5543. https://doi.org/10.1038/s41598-017-05282-4
Kim EK, Park HL, Park CK. Relationship Between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma. Sci Rep. 2017 07 17;7(1):5543. PubMed PMID: 28717139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma. AU - Kim,Eun Kyoung, AU - Park,Hae-Young Lopilly, AU - Park,Chan Kee, Y1 - 2017/07/17/ PY - 2017/02/15/received PY - 2017/05/25/accepted PY - 2017/7/19/entrez PY - 2017/7/19/pubmed PY - 2019/1/30/medline SP - 5543 EP - 5543 JF - Scientific reports JO - Sci Rep VL - 7 IS - 1 N2 - Glaucoma is a disease characterized by pathologic changes in inner retinal layers, which are comprised of retinal ganglion cells (RGCs). As retinal ganglion cells (RGCs) cross over other retinal neurons that are connected by synapses, it is meaningful to investigate the outer retinal changes in glaucoma. We evaluated the association between thicknesses of segmented retinal layers in macular region and severity of visual field loss in open-angle glaucoma (OAG). This study involved 103 glaucomatous eyes. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL) thicknesses were measured at the macular level using the Spectral-domain optical coherence tomography with segmentation software. The functional losses were measured using 24-2 standard automated perimetry. Macular structure losses were positively correlated with functional loss for RNFL, GCL, and IPL (R = 0.550, 0.637, and 0.649, respectively, P < 0.001) and negatively correlated with INL (R = -0.295, P = 0.041). By multivariate regression analysis, INL thickness was significantly associated with visual field mean deviation (dB) and optic disc hemorrhage. These finding carefully suggest reactive responses of neuronal or glial cells located in the INL occur during glaucoma progression. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/28717139/Relationship_between_Retinal_Inner_Nuclear_Layer_Thickness_and_Severity_of_Visual_Field_Loss_in_Glaucoma_ L2 - https://doi.org/10.1038/s41598-017-05282-4 DB - PRIME DP - Unbound Medicine ER -