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Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice.
Am J Trop Med Hyg. 2017 Jun; 96(6):1365-1369.AJ

Abstract

AbstractBurkholderia pseudomallei is the causative agent of melioidosis, an emerging tropical disease of high mortality. Sub-Saharan Africa represents potential melioidosis "hotspots"; however, to date, only a few cases have been reported. Here in, we compared the inflammatory patterns induced by a B. pseudomallei strain recently isolated from a fatal Gabonese case with the Thai reference strain B. pseudomallei-1026b and Burkholderia thailandensis-E264. Ex vivo, no differences were observed in terms of cellular responsiveness between strains. However, when compared with the B. pseudomallei-1026b strain, the Gabonese isolate was significantly less virulent in terms of bacterial dissemination, inflammatory response, and organ damage in mice. Genomic comparison between strains showed differences in regions containing a fimbriae/adhesion virulence protein. In addition to a lack of microbiology facilities, differences in virulence of Burkholderia strains might contribute to the diverse global clinical occurrence of melioidosis.

Authors+Show Affiliations

Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands. Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.Centre de Recherches Médicales en Lambaréné (CERMEL), Lambaréné, Gabon. Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands. Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands.Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands. Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands. Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands. Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.Institute of Tropical Medicine, University of Tübingen, Germany. Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands. Centre de Recherches Médicales en Lambaréné (CERMEL), Lambaréné, Gabon.Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands. Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands. Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28719265

Citation

Weehuizen, Tassili A F., et al. "Differences in Inflammation Patterns Induced By African and Asian Burkholderia Pseudomallei Isolates in Mice." The American Journal of Tropical Medicine and Hygiene, vol. 96, no. 6, 2017, pp. 1365-1369.
Weehuizen TAF, Birnie E, Ferwerda B, et al. Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice. Am J Trop Med Hyg. 2017;96(6):1365-1369.
Weehuizen, T. A. F., Birnie, E., Ferwerda, B., Roelofs, J. J. T. H., de Vos, A. F., Grobusch, M. P., & Wiersinga, W. J. (2017). Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice. The American Journal of Tropical Medicine and Hygiene, 96(6), 1365-1369. https://doi.org/10.4269/ajtmh.16-0121
Weehuizen TAF, et al. Differences in Inflammation Patterns Induced By African and Asian Burkholderia Pseudomallei Isolates in Mice. Am J Trop Med Hyg. 2017;96(6):1365-1369. PubMed PMID: 28719265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice. AU - Weehuizen,Tassili A F, AU - Birnie,Emma, AU - Ferwerda,Bart, AU - Roelofs,Joris J T H, AU - de Vos,Alex F, AU - Grobusch,Martin P, AU - Wiersinga,W Joost, PY - 2017/7/19/entrez PY - 2017/7/19/pubmed PY - 2017/8/24/medline SP - 1365 EP - 1369 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 96 IS - 6 N2 - AbstractBurkholderia pseudomallei is the causative agent of melioidosis, an emerging tropical disease of high mortality. Sub-Saharan Africa represents potential melioidosis "hotspots"; however, to date, only a few cases have been reported. Here in, we compared the inflammatory patterns induced by a B. pseudomallei strain recently isolated from a fatal Gabonese case with the Thai reference strain B. pseudomallei-1026b and Burkholderia thailandensis-E264. Ex vivo, no differences were observed in terms of cellular responsiveness between strains. However, when compared with the B. pseudomallei-1026b strain, the Gabonese isolate was significantly less virulent in terms of bacterial dissemination, inflammatory response, and organ damage in mice. Genomic comparison between strains showed differences in regions containing a fimbriae/adhesion virulence protein. In addition to a lack of microbiology facilities, differences in virulence of Burkholderia strains might contribute to the diverse global clinical occurrence of melioidosis. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/28719265/Differences_in_Inflammation_Patterns_Induced_by_African_and_Asian_Burkholderia_pseudomallei_Isolates_in_Mice_ L2 - http://www.ajtmh.org/content/journals/10.4269/ajtmh.16-0121?crawler=true&mimetype=application/pdf DB - PRIME DP - Unbound Medicine ER -