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Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives.
Stem Cell Rev Rep. 2017 Oct; 13(5):575-586.SC

Abstract

Large articular cartilage defects remain an immense challenge in the field of regenerative medicine because of their poor intrinsic repair capacity. Currently, the available medical interventions can relieve clinical symptoms to some extent, but fail to repair the cartilaginous injuries with authentic hyaline cartilage. There has been a surge of interest in developing cell-based therapies, focused particularly on the use of mesenchymal stem/progenitor cells with or without scaffolds. Mesenchymal stem/progenitor cells are promising graft cells for tissue regeneration, but the most suitable source of cells for cartilage repair remains controversial. The tissue origin of mesenchymal stem/progenitor cells notably influences the biological properties and therapeutic potential. It is well known that mesenchymal stem/progenitor cells derived from synovial joint tissues exhibit superior chondrogenic ability compared with those derived from non-joint tissues; thus, these cell populations are considered ideal sources for cartilage regeneration. In addition to the progress in research and promising preclinical results, many important research questions must be answered before widespread success in cartilage regeneration is achieved. This review outlines the biology of stem/progenitor cells derived from the articular cartilage, the synovial membrane, and the synovial fluid, including their tissue distribution, function and biological characteristics. Furthermore, preclinical and clinical trials focusing on their applications for cartilage regeneration are summarized, and future research perspectives are discussed.

Authors+Show Affiliations

Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu, China.Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu, China.Centro di Ricerca E. Menni, Fondazione Poliambulanza-Istituto Ospedaliero, Brescia, Italy.Centro di Ricerca E. Menni, Fondazione Poliambulanza-Istituto Ospedaliero, Brescia, Italy. Istituto di Anatomia Umana e Biologia Cellulare, Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Rome, Italy.Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu, China.Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu, China. dengli2000@gmail.com.Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Orthopaedic Research Center, Peking University Shenzhen Hospital, Shenzhen, China. y.c.huang@connect.hku.hk. Shenzhen Key Laboratory of Spine Surgery, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen, China. y.c.huang@connect.hku.hk. Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, SAR, China. y.c.huang@connect.hku.hk. Beijing Key Laboratory for Genetic Research of Bone and Joint Disease, Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. y.c.huang@connect.hku.hk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28721683

Citation

Huang, Yi-Zhou, et al. "Mesenchymal Stem/Progenitor Cells Derived From Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives." Stem Cell Reviews and Reports, vol. 13, no. 5, 2017, pp. 575-586.
Huang YZ, Xie HQ, Silini A, et al. Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives. Stem Cell Rev Rep. 2017;13(5):575-586.
Huang, Y. Z., Xie, H. Q., Silini, A., Parolini, O., Zhang, Y., Deng, L., & Huang, Y. C. (2017). Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives. Stem Cell Reviews and Reports, 13(5), 575-586. https://doi.org/10.1007/s12015-017-9753-1
Huang YZ, et al. Mesenchymal Stem/Progenitor Cells Derived From Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives. Stem Cell Rev Rep. 2017;13(5):575-586. PubMed PMID: 28721683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives. AU - Huang,Yi-Zhou, AU - Xie,Hui-Qi, AU - Silini,Antonietta, AU - Parolini,Ornella, AU - Zhang,Yi, AU - Deng,Li, AU - Huang,Yong-Can, PY - 2017/7/20/pubmed PY - 2018/6/29/medline PY - 2017/7/20/entrez KW - Articular cartilage KW - Mesenchymal stem cells KW - Regenerative medicine KW - Synovial fluid KW - Synovial joint KW - Synovial membrane KW - progenitors SP - 575 EP - 586 JF - Stem cell reviews and reports JO - Stem Cell Rev Rep VL - 13 IS - 5 N2 - Large articular cartilage defects remain an immense challenge in the field of regenerative medicine because of their poor intrinsic repair capacity. Currently, the available medical interventions can relieve clinical symptoms to some extent, but fail to repair the cartilaginous injuries with authentic hyaline cartilage. There has been a surge of interest in developing cell-based therapies, focused particularly on the use of mesenchymal stem/progenitor cells with or without scaffolds. Mesenchymal stem/progenitor cells are promising graft cells for tissue regeneration, but the most suitable source of cells for cartilage repair remains controversial. The tissue origin of mesenchymal stem/progenitor cells notably influences the biological properties and therapeutic potential. It is well known that mesenchymal stem/progenitor cells derived from synovial joint tissues exhibit superior chondrogenic ability compared with those derived from non-joint tissues; thus, these cell populations are considered ideal sources for cartilage regeneration. In addition to the progress in research and promising preclinical results, many important research questions must be answered before widespread success in cartilage regeneration is achieved. This review outlines the biology of stem/progenitor cells derived from the articular cartilage, the synovial membrane, and the synovial fluid, including their tissue distribution, function and biological characteristics. Furthermore, preclinical and clinical trials focusing on their applications for cartilage regeneration are summarized, and future research perspectives are discussed. SN - 2629-3277 UR - https://www.unboundmedicine.com/medline/citation/28721683/Mesenchymal_Stem/Progenitor_Cells_Derived_from_Articular_Cartilage_Synovial_Membrane_and_Synovial_Fluid_for_Cartilage_Regeneration:_Current_Status_and_Future_Perspectives_ L2 - https://doi.org/10.1007/s12015-017-9753-1 DB - PRIME DP - Unbound Medicine ER -