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Increased serum ferritin levels are independently associated with carotid atherosclerosis in women.
Br J Nutr 2017; 117(11):1623-1630BJ

Abstract

Previous studies have supported the theory that there is a positive association between ferritin and carotid atherosclerosis in Western people. Diet plays an important role in determining serum ferritin concentration. Asian dietary patterns are different from Western dietary patterns, implying that there may be a difference in the association of ferritin with carotid atherosclerosis between Asian and Western people. However, few studies focus on the association between ferritin and carotid atherosclerosis among Asians. The aim of this study was to investigate how serum ferritin levels are associated with carotid atherosclerosis in an Asian adult population. A cross-sectional assessment was performed in 8302 adults in Tianjin, China. Carotid intima-media thickness (IMT) and plaques were assessed using ultrasonography, and serum ferritin was measured using the protein chip-chemiluminescence method. Multiple logistic regression analysis was used to examine the association between quartiles of serum ferritin concentration and carotid atherosclerosis. In the present study, the overall prevalence of IMT and carotid plaques in participants is 29·2 and 22·7 %, respectively. In women, after adjustments for potentially confounding factors, the OR of IMT and carotid plaques by increasing serum ferritin quartiles were 1·00, 1·39 (95 % CI 0·98-1·99), 1·39 (95 % CI 0·99-1·97), 1·81 (95 % CI 1·30-2·55) (P for trend<0·001) and 1·00, 1·24 (95 % CI 0·89-1·73), 1·18 (95 % CI 0·85-1·65), 1·59 (95 % CI 1·15-2·20) (P for trend<0·01), respectively. However, no association was found between serum ferritin and carotid atherosclerosis in men. The study demonstrated that increased serum ferritin levels are independently associated with IMT and carotid plaques in Asian women but not in Asian men.

Authors+Show Affiliations

1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.2Tianjin University of Traditional Chinese Medicine,Tianjin 300193,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.3Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300070,People's Republic of China.3Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.3Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.3Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300070,People's Republic of China.3Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300070,People's Republic of China.3Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300070,People's Republic of China.3Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300070,People's Republic of China.3Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300070,People's Republic of China.3Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.1Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28721838

Citation

Xu, Haiyan, et al. "Increased Serum Ferritin Levels Are Independently Associated With Carotid Atherosclerosis in Women." The British Journal of Nutrition, vol. 117, no. 11, 2017, pp. 1623-1630.
Xu H, Song Y, Xu J, et al. Increased serum ferritin levels are independently associated with carotid atherosclerosis in women. Br J Nutr. 2017;117(11):1623-1630.
Xu, H., Song, Y., Xu, J., Gu, Y., Zhang, Q., Liu, L., ... Niu, K. (2017). Increased serum ferritin levels are independently associated with carotid atherosclerosis in women. The British Journal of Nutrition, 117(11), pp. 1623-1630. doi:10.1017/S0007114517001544.
Xu H, et al. Increased Serum Ferritin Levels Are Independently Associated With Carotid Atherosclerosis in Women. Br J Nutr. 2017;117(11):1623-1630. PubMed PMID: 28721838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased serum ferritin levels are independently associated with carotid atherosclerosis in women. AU - Xu,Haiyan, AU - Song,Yanqi, AU - Xu,Jing, AU - Gu,Yeqing, AU - Zhang,Qing, AU - Liu,Li, AU - Meng,Ge, AU - Wu,Hongmei, AU - Xia,Yang, AU - Bao,Xue, AU - Shi,Hongbin, AU - Su,Qian, AU - Fang,Liyun, AU - Yu,Fei, AU - Yang,Huijun, AU - Sun,Shaomei, AU - Wang,Xing, AU - Zhou,Ming, AU - Jia,Qiyu, AU - Wang,Guolin, AU - Song,Kun, AU - Wu,Yuntang, AU - Sun,Zhong, AU - Niu,Kaijun, PY - 2017/7/20/entrez PY - 2017/7/20/pubmed PY - 2017/8/2/medline KW - FBG fasting blood glucose KW - IMT intima-media thickness KW - ROS reactive oxygen species KW - Asian population KW - Carotid atherosclerosis KW - Carotid intima-media thickness KW - Carotid plaques KW - Ferritin SP - 1623 EP - 1630 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 117 IS - 11 N2 - Previous studies have supported the theory that there is a positive association between ferritin and carotid atherosclerosis in Western people. Diet plays an important role in determining serum ferritin concentration. Asian dietary patterns are different from Western dietary patterns, implying that there may be a difference in the association of ferritin with carotid atherosclerosis between Asian and Western people. However, few studies focus on the association between ferritin and carotid atherosclerosis among Asians. The aim of this study was to investigate how serum ferritin levels are associated with carotid atherosclerosis in an Asian adult population. A cross-sectional assessment was performed in 8302 adults in Tianjin, China. Carotid intima-media thickness (IMT) and plaques were assessed using ultrasonography, and serum ferritin was measured using the protein chip-chemiluminescence method. Multiple logistic regression analysis was used to examine the association between quartiles of serum ferritin concentration and carotid atherosclerosis. In the present study, the overall prevalence of IMT and carotid plaques in participants is 29·2 and 22·7 %, respectively. In women, after adjustments for potentially confounding factors, the OR of IMT and carotid plaques by increasing serum ferritin quartiles were 1·00, 1·39 (95 % CI 0·98-1·99), 1·39 (95 % CI 0·99-1·97), 1·81 (95 % CI 1·30-2·55) (P for trend<0·001) and 1·00, 1·24 (95 % CI 0·89-1·73), 1·18 (95 % CI 0·85-1·65), 1·59 (95 % CI 1·15-2·20) (P for trend<0·01), respectively. However, no association was found between serum ferritin and carotid atherosclerosis in men. The study demonstrated that increased serum ferritin levels are independently associated with IMT and carotid plaques in Asian women but not in Asian men. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/28721838/Increased_serum_ferritin_levels_are_independently_associated_with_carotid_atherosclerosis_in_women_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517001544/type/journal_article DB - PRIME DP - Unbound Medicine ER -