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Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort.
Int J Cancer 2017; 141(10):1963-1970IJ

Abstract

Findings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35-70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 incident cases) were calculated using Cox proportional hazards models. Alcohol consumption at baseline and over the life course was analyzed, as well as different types of beverages (beer, wine, spirits). Baseline alcohol intake was associated with a statistically nonsignificant increased risk of UCC (HR 1.03; 95% confidence interval (CI) 1.00-1.06 for each additional 12 g/day). HR in smokers was 1.04 (95% CI 1.01-1.07). Men reporting high baseline intakes of alcohol (>96 g/day) had an increased risk of UCC (HR 1.57; 95% CI 1.03-2.40) compared to those reporting moderate intakes (<6 g/day), but no dose-response relationship emerged. In men, an increased risk of aggressive forms of UCC was observed even at lower doses (>6 to 24 g/day). Average lifelong alcohol intake was not associated with the risk of UCC, however intakes of spirits > 24 g/day were associated with an increased risk of UCC in men (1.38; 95% CI 1.01-1.91) and smokers (1.39; 95% CI 1.01-1.92), compared to moderate intakes. We found no association between alcohol and UCC in women and never smokers. In conclusion, we observed some associations between alcohol and UCC in men and in smokers, possibly because of residual confounding by tobacco smoking.

Authors+Show Affiliations

Department of Bowel Cancer Screening, Cancer Registry of Norway, Oslo University Hospital, Oslo, Norway. National Advisory Unit for Women's Health, Women's Clinic, Oslo University Hospital, Oslo, Norway.International Agency for Research on Cancer, Lyon, France.Danish Cancer Society Research Center, Copenhagen, Denmark.Danish Cancer Society Research Center, Copenhagen, Denmark.Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Spain.Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.Hellenic Health Foundation, Athens, Greece. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Athens, Greece.Hellenic Health Foundation, Athens, Greece. 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece.Hellenic Health Foundation, Athens, Greece. Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine. Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.Department of Translational Medicine, Division of Clinical and Experimental Urothelial Carcinoma Research, Lund University, Malmö, Sweden.Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs. Granada. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.International Agency for Research on Cancer, Lyon, France.International Agency for Research on Cancer, Lyon, France.Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.International Agency for Research on Cancer, Lyon, France. Department for biobank research, Umeå University, Umeå, Sweden.Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.Dipartimento di medicina clinica e chirurgia, Federico II University, Naples, Italy.Cancer Registry and Histopathology Unit "Civic - M.P. Arezzo" Hospital ASP, Ragusa, Italy.Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom.Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28722206

Citation

Botteri, E, et al. "Alcohol Consumption and Risk of Urothelial Cell Bladder Cancer in the European Prospective Investigation Into Cancer and Nutrition Cohort." International Journal of Cancer, vol. 141, no. 10, 2017, pp. 1963-1970.
Botteri E, Ferrari P, Roswall N, et al. Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort. Int J Cancer. 2017;141(10):1963-1970.
Botteri, E., Ferrari, P., Roswall, N., Tjønneland, A., Hjartåker, A., Huerta, J. M., ... Weiderpass, E. (2017). Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort. International Journal of Cancer, 141(10), pp. 1963-1970. doi:10.1002/ijc.30894.
Botteri E, et al. Alcohol Consumption and Risk of Urothelial Cell Bladder Cancer in the European Prospective Investigation Into Cancer and Nutrition Cohort. Int J Cancer. 2017 11 15;141(10):1963-1970. PubMed PMID: 28722206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort. AU - Botteri,E, AU - Ferrari,P, AU - Roswall,N, AU - Tjønneland,A, AU - Hjartåker,A, AU - Huerta,J M, AU - Fortner,R T, AU - Trichopoulou,A, AU - Karakatsani,A, AU - La Vecchia,C, AU - Pala,V, AU - Perez-Cornago,A, AU - Sonestedt,E, AU - Liedberg,F, AU - Overvad,K, AU - Sánchez,M J, AU - Gram,I T, AU - Stepien,M, AU - Trijsburg,L, AU - Börje,L, AU - Johansson,M, AU - Kühn,T, AU - Panico,S, AU - Tumino,R, AU - Bueno-de-Mesquita,H B As, AU - Weiderpass,E, Y1 - 2017/07/31/ PY - 2017/04/20/received PY - 2017/06/16/revised PY - 2017/06/28/accepted PY - 2017/7/20/pubmed PY - 2017/10/28/medline PY - 2017/7/20/entrez KW - alcohol KW - alcoholic beverages KW - bladder cancer KW - cancer stage KW - cohort study SP - 1963 EP - 1970 JF - International journal of cancer JO - Int. J. Cancer VL - 141 IS - 10 N2 - Findings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35-70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 incident cases) were calculated using Cox proportional hazards models. Alcohol consumption at baseline and over the life course was analyzed, as well as different types of beverages (beer, wine, spirits). Baseline alcohol intake was associated with a statistically nonsignificant increased risk of UCC (HR 1.03; 95% confidence interval (CI) 1.00-1.06 for each additional 12 g/day). HR in smokers was 1.04 (95% CI 1.01-1.07). Men reporting high baseline intakes of alcohol (>96 g/day) had an increased risk of UCC (HR 1.57; 95% CI 1.03-2.40) compared to those reporting moderate intakes (<6 g/day), but no dose-response relationship emerged. In men, an increased risk of aggressive forms of UCC was observed even at lower doses (>6 to 24 g/day). Average lifelong alcohol intake was not associated with the risk of UCC, however intakes of spirits > 24 g/day were associated with an increased risk of UCC in men (1.38; 95% CI 1.01-1.91) and smokers (1.39; 95% CI 1.01-1.92), compared to moderate intakes. We found no association between alcohol and UCC in women and never smokers. In conclusion, we observed some associations between alcohol and UCC in men and in smokers, possibly because of residual confounding by tobacco smoking. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/28722206/Alcohol_consumption_and_risk_of_urothelial_cell_bladder_cancer_in_the_European_prospective_investigation_into_cancer_and_nutrition_cohort_ L2 - https://doi.org/10.1002/ijc.30894 DB - PRIME DP - Unbound Medicine ER -