Tags

Type your tag names separated by a space and hit enter

[Comparison of the effect of linolenic acid and eicosapentaenoic acid on prostaglandin biosynthesis and thrombocyte function in humans].
Klin Wochenschr. 1986 Mar 17; 64(6):274-80.KW

Abstract

Platelet aggregation, bleeding time, prostaglandin biosynthesis and plasma cholesterol fatty acids were investigated in 12 healthy females (25-32 years), who were given different amounts of linolenic acid (0%, 4%, 8%, 12%, 16% of total energy intake) or eicosapentaenoic acid (1.7%) with formula diets for 2 weeks each. Linolenic and eicosapentaenoic acids prolonged the bleeding time and inhibited platelet aggregation and prostaglandin biosynthesis. These effects became apparent after a linolenic acid intake of 12% of the energy intake. A decrease in PGE in 24 h urine was observed after intake of linolenic acid amounting to 8% of energy intake. Eicosapentaenoic acid influenced all parameters measured ten times more than linolenic acid. Linolenic acid intake had no effect on the ratio of linoleic/arachidonic acids in plasma cholesterol esters in contrast to in vitro findings. Thus energy intake comprising 1.7% of eicosapentaenoic acid is sufficient to affect thrombocyte function in man. The concomitant intake of linolenic-type fatty acids inhibits the biosynthesis of prostaglandins E2 and F2 alpha to different degrees.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

2872365

Citation

Adam, O, et al. "[Comparison of the Effect of Linolenic Acid and Eicosapentaenoic Acid On Prostaglandin Biosynthesis and Thrombocyte Function in Humans]." Klinische Wochenschrift, vol. 64, no. 6, 1986, pp. 274-80.
Adam O, Wolfram G, Zöllner N. [Comparison of the effect of linolenic acid and eicosapentaenoic acid on prostaglandin biosynthesis and thrombocyte function in humans]. Klin Wochenschr. 1986;64(6):274-80.
Adam, O., Wolfram, G., & Zöllner, N. (1986). [Comparison of the effect of linolenic acid and eicosapentaenoic acid on prostaglandin biosynthesis and thrombocyte function in humans]. Klinische Wochenschrift, 64(6), 274-80.
Adam O, Wolfram G, Zöllner N. [Comparison of the Effect of Linolenic Acid and Eicosapentaenoic Acid On Prostaglandin Biosynthesis and Thrombocyte Function in Humans]. Klin Wochenschr. 1986 Mar 17;64(6):274-80. PubMed PMID: 2872365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison of the effect of linolenic acid and eicosapentaenoic acid on prostaglandin biosynthesis and thrombocyte function in humans]. AU - Adam,O, AU - Wolfram,G, AU - Zöllner,N, PY - 1986/3/17/pubmed PY - 1986/3/17/medline PY - 1986/3/17/entrez SP - 274 EP - 80 JF - Klinische Wochenschrift JO - Klin Wochenschr VL - 64 IS - 6 N2 - Platelet aggregation, bleeding time, prostaglandin biosynthesis and plasma cholesterol fatty acids were investigated in 12 healthy females (25-32 years), who were given different amounts of linolenic acid (0%, 4%, 8%, 12%, 16% of total energy intake) or eicosapentaenoic acid (1.7%) with formula diets for 2 weeks each. Linolenic and eicosapentaenoic acids prolonged the bleeding time and inhibited platelet aggregation and prostaglandin biosynthesis. These effects became apparent after a linolenic acid intake of 12% of the energy intake. A decrease in PGE in 24 h urine was observed after intake of linolenic acid amounting to 8% of energy intake. Eicosapentaenoic acid influenced all parameters measured ten times more than linolenic acid. Linolenic acid intake had no effect on the ratio of linoleic/arachidonic acids in plasma cholesterol esters in contrast to in vitro findings. Thus energy intake comprising 1.7% of eicosapentaenoic acid is sufficient to affect thrombocyte function in man. The concomitant intake of linolenic-type fatty acids inhibits the biosynthesis of prostaglandins E2 and F2 alpha to different degrees. SN - 0023-2173 UR - https://www.unboundmedicine.com/medline/citation/2872365/[Comparison_of_the_effect_of_linolenic_acid_and_eicosapentaenoic_acid_on_prostaglandin_biosynthesis_and_thrombocyte_function_in_humans]_ DB - PRIME DP - Unbound Medicine ER -