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Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism.
Eur Rev Med Pharmacol Sci 2017; 21(2 Suppl):51-59ER

Abstract

OBJECTIVE

Clinical evidence suggests that oral supplementation with myo-inositol (MI) and selenium (Se) is useful in the treatment of autoimmune thyroiditis. The purpose of this study was to highlight the positive response of Hashimoto's patients with subclinical hypothyroidism (SH) treated with MI and Se (MI-Se) in restoring a normal thyroid function.

PATIENTS AND METHODS

A total of 168 patients with Hashimoto's thyroiditis (HT) having Thyroid Stimulating Hormone (TSH) levels between 3 and 6 µIU/ml were randomized into 2 groups: one receiving MI-Se and the other one Se alone.

RESULTS

TSH, anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels were significantly decreased in patients treated with combined MI-Se after six months of treatment. Also, a significant free serum T4 increase was observed in MI-Se group, along with an amelioration of patients' quality of life.

CONCLUSIONS

The administration of MI-Se is significantly effective in decreasing TSH, TPOAb and TgAb levels, as well as in enhancing thyroid hormones and personal wellbeing. Such treatment restored euthyroidism in patients diagnosed with autoimmune thyroiditis.

Authors+Show Affiliations

Department of Experimental Medicine, University of Rome "Sapienza", Rome, Italy. maurizionordio1@gmail.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28724185

Citation

Nordio, M, and S Basciani. "Myo-inositol Plus Selenium Supplementation Restores Euthyroid State in Hashimoto's Patients With Subclinical Hypothyroidism." European Review for Medical and Pharmacological Sciences, vol. 21, no. 2 Suppl, 2017, pp. 51-59.
Nordio M, Basciani S. Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):51-59.
Nordio, M., & Basciani, S. (2017). Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism. European Review for Medical and Pharmacological Sciences, 21(2 Suppl), pp. 51-59.
Nordio M, Basciani S. Myo-inositol Plus Selenium Supplementation Restores Euthyroid State in Hashimoto's Patients With Subclinical Hypothyroidism. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):51-59. PubMed PMID: 28724185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism. AU - Nordio,M, AU - Basciani,S, PY - 2017/7/21/entrez PY - 2017/7/21/pubmed PY - 2018/7/19/medline SP - 51 EP - 59 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 21 IS - 2 Suppl N2 - OBJECTIVE: Clinical evidence suggests that oral supplementation with myo-inositol (MI) and selenium (Se) is useful in the treatment of autoimmune thyroiditis. The purpose of this study was to highlight the positive response of Hashimoto's patients with subclinical hypothyroidism (SH) treated with MI and Se (MI-Se) in restoring a normal thyroid function. PATIENTS AND METHODS: A total of 168 patients with Hashimoto's thyroiditis (HT) having Thyroid Stimulating Hormone (TSH) levels between 3 and 6 µIU/ml were randomized into 2 groups: one receiving MI-Se and the other one Se alone. RESULTS: TSH, anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels were significantly decreased in patients treated with combined MI-Se after six months of treatment. Also, a significant free serum T4 increase was observed in MI-Se group, along with an amelioration of patients' quality of life. CONCLUSIONS: The administration of MI-Se is significantly effective in decreasing TSH, TPOAb and TgAb levels, as well as in enhancing thyroid hormones and personal wellbeing. Such treatment restored euthyroidism in patients diagnosed with autoimmune thyroiditis. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/28724185/Myo_inositol_plus_selenium_supplementation_restores_euthyroid_state_in_Hashimoto's_patients_with_subclinical_hypothyroidism_ L2 - http://www.europeanreview.org/article/12297 DB - PRIME DP - Unbound Medicine ER -