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Farming and incidence of motor neuron disease: French nationwide study.
Eur J Neurol 2017; 24(9):1191-1195EJ

Abstract

BACKGROUND AND PURPOSE

The association of farming with motor neuron disease (MND) is unclear, with conflicting studies. We performed a French nationwide study of the association of farming with MND incidence, and compared findings with those for Parkinson's disease (PD), which has been shown to be more frequent in farmers.

METHODS

We used the French national health insurance and hospital discharge databases to identify MND/PD incident cases. The Mutualité Sociale Agricole (MSA) guarantees health insurance for farmers and agricultural workers. We compared the incidence of MND (2010-2014) and PD (2011-2012) in MSA farmers, MSA workers and non-MSA affiliates, and estimated relative risks (RRs) and 95% confidence intervals (CIs). Probabilistic sensitivity analyses were used for external smoking adjustment.

RESULTS

Analyses relied on 8931 MND (MSA, 9%) and 45 409 PD (MSA,11%) cases. There was a trend towards higher MND incidence in MSA farmers compared with non-MSA affiliates (RR,1.08; 95% CI,0.99-1.18) and MSA workers (RR, 1.13; 95% CI, 0.97-1.31) that strengthened after smoking adjustment (if associated with MND). PD incidence was higher in MSA farmers than non-MSA affiliates (RR, 1.13; 95% CI, 1.08-1.17) and MSA workers (RR, 1.10; 95% CI, 1.02-1.18); this association remained after smoking adjustment (RR, 1.09; 95% CI, 1.05-1.14).

CONCLUSIONS

This French nationwide study suggested an association between farming and MND, and confirmed higher PD incidence in farmers in France, a country with high pesticide use.

Authors+Show Affiliations

Santé publique France, Saint-Maurice. Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.Santé publique France, Saint-Maurice. Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28727213

Citation

Kab, S, et al. "Farming and Incidence of Motor Neuron Disease: French Nationwide Study." European Journal of Neurology, vol. 24, no. 9, 2017, pp. 1191-1195.
Kab S, Moisan F, Elbaz A. Farming and incidence of motor neuron disease: French nationwide study. Eur J Neurol. 2017;24(9):1191-1195.
Kab, S., Moisan, F., & Elbaz, A. (2017). Farming and incidence of motor neuron disease: French nationwide study. European Journal of Neurology, 24(9), pp. 1191-1195. doi:10.1111/ene.13353.
Kab S, Moisan F, Elbaz A. Farming and Incidence of Motor Neuron Disease: French Nationwide Study. Eur J Neurol. 2017;24(9):1191-1195. PubMed PMID: 28727213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Farming and incidence of motor neuron disease: French nationwide study. AU - Kab,S, AU - Moisan,F, AU - Elbaz,A, Y1 - 2017/07/20/ PY - 2017/01/10/received PY - 2017/06/01/accepted PY - 2017/7/21/pubmed PY - 2018/3/24/medline PY - 2017/7/21/entrez KW - Parkinson's disease KW - agriculture KW - epidemiology KW - farmers KW - motor neuron disease KW - occupational SP - 1191 EP - 1195 JF - European journal of neurology JO - Eur. J. Neurol. VL - 24 IS - 9 N2 - BACKGROUND AND PURPOSE: The association of farming with motor neuron disease (MND) is unclear, with conflicting studies. We performed a French nationwide study of the association of farming with MND incidence, and compared findings with those for Parkinson's disease (PD), which has been shown to be more frequent in farmers. METHODS: We used the French national health insurance and hospital discharge databases to identify MND/PD incident cases. The Mutualité Sociale Agricole (MSA) guarantees health insurance for farmers and agricultural workers. We compared the incidence of MND (2010-2014) and PD (2011-2012) in MSA farmers, MSA workers and non-MSA affiliates, and estimated relative risks (RRs) and 95% confidence intervals (CIs). Probabilistic sensitivity analyses were used for external smoking adjustment. RESULTS: Analyses relied on 8931 MND (MSA, 9%) and 45 409 PD (MSA,11%) cases. There was a trend towards higher MND incidence in MSA farmers compared with non-MSA affiliates (RR,1.08; 95% CI,0.99-1.18) and MSA workers (RR, 1.13; 95% CI, 0.97-1.31) that strengthened after smoking adjustment (if associated with MND). PD incidence was higher in MSA farmers than non-MSA affiliates (RR, 1.13; 95% CI, 1.08-1.17) and MSA workers (RR, 1.10; 95% CI, 1.02-1.18); this association remained after smoking adjustment (RR, 1.09; 95% CI, 1.05-1.14). CONCLUSIONS: This French nationwide study suggested an association between farming and MND, and confirmed higher PD incidence in farmers in France, a country with high pesticide use. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/28727213/Farming_and_incidence_of_motor_neuron_disease:_French_nationwide_study_ L2 - https://doi.org/10.1111/ene.13353 DB - PRIME DP - Unbound Medicine ER -