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First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls.
Environ Health Perspect. 2017 07 11; 125(7):077008.EH

Abstract

INTRODUCTION

Evidence from animal models suggests that prenatal exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is associated with adverse reproductive outcomes in females. Exposure during early gestation, a critical period for reproductive development, is of particular concern. Anogenital distance (AGD) is a sensitive biomarker of the fetal hormonal milieu and a measure of reproductive toxicity in animal models. In some studies, the daughters of BPA-exposed dams have shorter AGD than controls. Here, we investigate this relationship in humans.

METHODS

BPA was assayed in first-trimester urine samples from 385 participants who delivered infant girls in a multicenter pregnancy cohort study. After birth, daughters underwent exams that included two measures of AGD (AGD-AC: distance from center of anus to clitoris; AGD-AF: distance from center of anus to fourchette). We fit linear regression models to examine the association between specific gravity-adjusted (SPG-adj) maternal BPA concentrations and infant AGD, adjusting for covariates.

RESULTS

BPA was detectable in 94% of women. In covariate-adjusted models fit on 381 eligible subjects, the natural logarithm of SpG-adj maternal BPA concentration was inversely associated with infant AGD-AC [β=−0.56, 95% confidence interval (CI): −0.97, −0.15]. We observed no association between maternal BPA and infant AGD-AF.

CONCLUSION

BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. https://doi.org/10.1289/EHP875.

Authors+Show Affiliations

Department of Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers University School of Public Health, Piscataway, New Jersey, USA Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USADepartment of Pediatrics, University of Washington, Seattle, Washington, USA Seattle Children’s Research Institute, Seattle, Washington, USADepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USADepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USADepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USADepartment of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28728138

Citation

Barrett, Emily S., et al. "First-Trimester Urinary Bisphenol a Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls." Environmental Health Perspectives, vol. 125, no. 7, 2017, p. 077008.
Barrett ES, Sathyanarayana S, Mbowe O, et al. First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls. Environ Health Perspect. 2017;125(7):077008.
Barrett, E. S., Sathyanarayana, S., Mbowe, O., Thurston, S. W., Redmon, J. B., Nguyen, R. H. N., & Swan, S. H. (2017). First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls. Environmental Health Perspectives, 125(7), 077008. https://doi.org/10.1289/EHP875
Barrett ES, et al. First-Trimester Urinary Bisphenol a Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls. Environ Health Perspect. 2017 07 11;125(7):077008. PubMed PMID: 28728138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls. AU - Barrett,Emily S, AU - Sathyanarayana,Sheela, AU - Mbowe,Omar, AU - Thurston,Sally W, AU - Redmon,J Bruce, AU - Nguyen,Ruby H N, AU - Swan,Shanna H, Y1 - 2017/07/11/ PY - 2016/07/27/received PY - 2017/01/18/revised PY - 2017/01/19/accepted PY - 2017/7/21/entrez PY - 2017/7/21/pubmed PY - 2017/11/7/medline SP - 077008 EP - 077008 JF - Environmental health perspectives JO - Environ Health Perspect VL - 125 IS - 7 N2 - INTRODUCTION: Evidence from animal models suggests that prenatal exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is associated with adverse reproductive outcomes in females. Exposure during early gestation, a critical period for reproductive development, is of particular concern. Anogenital distance (AGD) is a sensitive biomarker of the fetal hormonal milieu and a measure of reproductive toxicity in animal models. In some studies, the daughters of BPA-exposed dams have shorter AGD than controls. Here, we investigate this relationship in humans. METHODS: BPA was assayed in first-trimester urine samples from 385 participants who delivered infant girls in a multicenter pregnancy cohort study. After birth, daughters underwent exams that included two measures of AGD (AGD-AC: distance from center of anus to clitoris; AGD-AF: distance from center of anus to fourchette). We fit linear regression models to examine the association between specific gravity-adjusted (SPG-adj) maternal BPA concentrations and infant AGD, adjusting for covariates. RESULTS: BPA was detectable in 94% of women. In covariate-adjusted models fit on 381 eligible subjects, the natural logarithm of SpG-adj maternal BPA concentration was inversely associated with infant AGD-AC [β=−0.56, 95% confidence interval (CI): −0.97, −0.15]. We observed no association between maternal BPA and infant AGD-AF. CONCLUSION: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. https://doi.org/10.1289/EHP875. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/28728138/First_Trimester_Urinary_Bisphenol_A_Concentration_in_Relation_to_Anogenital_Distance_an_Androgen_Sensitive_Measure_of_Reproductive_Development_in_Infant_Girls_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/EHP875?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -