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The skin as a window to the blood: Cutaneous manifestations of myeloid malignancies.
Blood Rev. 2017 11; 31(6):370-388.BR

Abstract

Cutaneous manifestations of myeloid malignancies are common and have a broad range of presentations. These skin findings are classified as specific, due to direct infiltration by malignant hematopoietic cells, or non-specific. Early recognition and diagnosis can have significant clinical implications, as skin manifestations may be the first indication of underlying hematologic malignancy, can reflect the immune status and stage of disease, and cutaneous reactions may occur from conventional and targeted agents used to treat myeloid disease. In addition, infections with cutaneous involvement are common in immunocompromised patients with myeloid disease. Given the varying presentations, dermatologic findings associated with myeloid malignancies can pose diagnostic challenges for hematologists and dermatologists. In this clinical review intended for the practicing hematologist/oncologist, we discuss the presentation, diagnosis, treatment, and prognostic value of the most common cutaneous manifestations associated with myeloid malignancies using illustrative macro- and microscopic figures and with a special emphasis on practical considerations.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li AW
Department of Dermatology, Yale School of Medicine, New Haven, USA.
Yin ES
Department of Dermatology, Yale School of Medicine, New Haven, USA.
Stahl M
Department of Medicine (Hematology), Yale School of Medicine, New Haven, USA.
Kim TK
Department of Medicine (Hematology), Yale School of Medicine, New Haven, USA.
Panse G
Department of Dermatology, Yale School of Medicine, New Haven, USA.
Zeidan AM
Department of Medicine (Hematology), Yale School of Medicine, New Haven, USA.
Leventhal JS
Department of Dermatology, Yale School of Medicine, New Haven, USA. Electronic address: jonathan.leventhal@yale.edu.

MeSH

AnimalsDermatomycosesHematologic NeoplasmsHumansSkinSkin DiseasesSkin Diseases, BacterialSkin Diseases, Viral

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28732587

Citation

Li, Alvin W., et al. "The Skin as a Window to the Blood: Cutaneous Manifestations of Myeloid Malignancies." Blood Reviews, vol. 31, no. 6, 2017, pp. 370-388.
Li AW, Yin ES, Stahl M, et al. The skin as a window to the blood: Cutaneous manifestations of myeloid malignancies. Blood Rev. 2017;31(6):370-388.
Li, A. W., Yin, E. S., Stahl, M., Kim, T. K., Panse, G., Zeidan, A. M., & Leventhal, J. S. (2017). The skin as a window to the blood: Cutaneous manifestations of myeloid malignancies. Blood Reviews, 31(6), 370-388. https://doi.org/10.1016/j.blre.2017.07.003
Li AW, et al. The Skin as a Window to the Blood: Cutaneous Manifestations of Myeloid Malignancies. Blood Rev. 2017;31(6):370-388. PubMed PMID: 28732587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The skin as a window to the blood: Cutaneous manifestations of myeloid malignancies. AU - Li,Alvin W, AU - Yin,Emily S, AU - Stahl,Maximilian, AU - Kim,Tae Kon, AU - Panse,Gauri, AU - Zeidan,Amer M, AU - Leventhal,Jonathan S, Y1 - 2017/07/14/ PY - 2017/03/30/received PY - 2017/05/26/revised PY - 2017/07/11/accepted PY - 2017/7/25/pubmed PY - 2018/6/13/medline PY - 2017/7/23/entrez KW - Dermatology KW - Leukemia KW - Leukemia cutis KW - Myeloid malignancies KW - Paraneoplastic KW - Skin SP - 370 EP - 388 JF - Blood reviews JO - Blood Rev VL - 31 IS - 6 N2 - Cutaneous manifestations of myeloid malignancies are common and have a broad range of presentations. These skin findings are classified as specific, due to direct infiltration by malignant hematopoietic cells, or non-specific. Early recognition and diagnosis can have significant clinical implications, as skin manifestations may be the first indication of underlying hematologic malignancy, can reflect the immune status and stage of disease, and cutaneous reactions may occur from conventional and targeted agents used to treat myeloid disease. In addition, infections with cutaneous involvement are common in immunocompromised patients with myeloid disease. Given the varying presentations, dermatologic findings associated with myeloid malignancies can pose diagnostic challenges for hematologists and dermatologists. In this clinical review intended for the practicing hematologist/oncologist, we discuss the presentation, diagnosis, treatment, and prognostic value of the most common cutaneous manifestations associated with myeloid malignancies using illustrative macro- and microscopic figures and with a special emphasis on practical considerations. SN - 1532-1681 UR - https://www.unboundmedicine.com/medline/citation/28732587/The_skin_as_a_window_to_the_blood:_Cutaneous_manifestations_of_myeloid_malignancies_ DB - PRIME DP - Unbound Medicine ER -