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Carotid artery intimal medial thickness and carotid artery plaques in hypertensive patients with non-arteritic anterior ischaemic optic neuropathy.
Graefes Arch Clin Exp Ophthalmol. 2017 Oct; 255(10):2037-2043.GA

Abstract

PURPOSE

To assess the correlation of carotid artery intimal medial thickness (C-IMT) and carotid artery plaque score (CPS) of the common carotid artery with non-arteritic anterior ischemic optic neuropathy (NAION) in hypertensive patients.

METHODS

This case-control study recruited 192 subjects. Forty-eight patients had NAION with systemic hypertension, 46 had hypertension without visual complaints, and 98 were normal controls. C-IMT and common carotid arterial plaque were measured by high-resolution vascular ultrasonography.

RESULTS

High-density lipoprotein (HDL) in patients with NAION (1.24 ± 0.31) was significantly lower than that of the Hypertensive group (1.39 ± 0.30, P = 0.034). The C-IMT in the affected side of patients with NAION (1.00 ± 0.23) was significantly increased compared to the unaffected side (0.83 ± 0.19, P < 0.001), the Hypertensive group (0.83 ± 0.17, P < 0.001), and the Normal group (0.69 ± 0.16, P < 0.001). The presence of carotid artery plaque was more frequent in the patients with NAION, compared to either the Hypertensive group (P = 0.001) or the Normal group (P < 0.001). By multiple regression analysis, lower high-density lipoprotein (HDL) (P = 0.009), thicker C-IMT (P = 0.002), CPS Grade = 1 (P = 0.028), and Grade = 2 (P = 0.005) were associated with increased NAION risk, when the NAION group compared with the Hypertensive group (OR > 1.0). Systolic blood pressure (P = 0.001), thicker C-IMT (P < 0.001), CPS Grade = 1 (P = 0.006), Grade = 2 (P = 0.002), and Grade = 3 (P = 0.015) were associated with increased NAION risk, when the NAION group compared with the Normal group (OR > 1.0).

CONCLUSIONS

C-IMT and CPS were associated with NAION in hypertensive patients, suggesting that NAION might be associated with carotid artery atherosclerosis. This association may be due to similar pathological changes of the inner vascular walls in the carotid artery and the arteries supplying the optic nerve head.

Authors+Show Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S. Xianlie Road, Guangzhou, People's Republic of China, 510060. Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S. Xianlie Road, Guangzhou, People's Republic of China, 510060. Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S. Xianlie Road, Guangzhou, People's Republic of China, 510060.School of Medicine, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.Department of Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S. Xianlie Road, Guangzhou, People's Republic of China, 510060.Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S. Xianlie Road, Guangzhou, People's Republic of China, 510060. ncongdon1@gmail.com. Centre for Public Health, Queen's University Belfast, Belfast, BT12 6BJ, UK. ncongdon1@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28733725

Citation

Zhu, Wenhui, et al. "Carotid Artery Intimal Medial Thickness and Carotid Artery Plaques in Hypertensive Patients With Non-arteritic Anterior Ischaemic Optic Neuropathy." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 255, no. 10, 2017, pp. 2037-2043.
Zhu W, Chen T, Jin L, et al. Carotid artery intimal medial thickness and carotid artery plaques in hypertensive patients with non-arteritic anterior ischaemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2017;255(10):2037-2043.
Zhu, W., Chen, T., Jin, L., Wang, H., Yao, F., Wang, C., Wang, Q., & Congdon, N. (2017). Carotid artery intimal medial thickness and carotid artery plaques in hypertensive patients with non-arteritic anterior ischaemic optic neuropathy. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 255(10), 2037-2043. https://doi.org/10.1007/s00417-017-3744-4
Zhu W, et al. Carotid Artery Intimal Medial Thickness and Carotid Artery Plaques in Hypertensive Patients With Non-arteritic Anterior Ischaemic Optic Neuropathy. Graefes Arch Clin Exp Ophthalmol. 2017;255(10):2037-2043. PubMed PMID: 28733725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid artery intimal medial thickness and carotid artery plaques in hypertensive patients with non-arteritic anterior ischaemic optic neuropathy. AU - Zhu,Wenhui, AU - Chen,Tingting, AU - Jin,Ling, AU - Wang,Haoyu, AU - Yao,Fengjuan, AU - Wang,Congyao, AU - Wang,Qi, AU - Congdon,Nathan, Y1 - 2017/07/22/ PY - 2017/04/17/received PY - 2017/07/03/accepted PY - 2017/06/21/revised PY - 2017/7/25/pubmed PY - 2018/1/11/medline PY - 2017/7/23/entrez KW - Carotid artery plaque KW - Doppler sonography KW - Intimal medial thickness KW - Non-arteritic anterior ischaemic optic neuropathy SP - 2037 EP - 2043 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 255 IS - 10 N2 - PURPOSE: To assess the correlation of carotid artery intimal medial thickness (C-IMT) and carotid artery plaque score (CPS) of the common carotid artery with non-arteritic anterior ischemic optic neuropathy (NAION) in hypertensive patients. METHODS: This case-control study recruited 192 subjects. Forty-eight patients had NAION with systemic hypertension, 46 had hypertension without visual complaints, and 98 were normal controls. C-IMT and common carotid arterial plaque were measured by high-resolution vascular ultrasonography. RESULTS: High-density lipoprotein (HDL) in patients with NAION (1.24 ± 0.31) was significantly lower than that of the Hypertensive group (1.39 ± 0.30, P = 0.034). The C-IMT in the affected side of patients with NAION (1.00 ± 0.23) was significantly increased compared to the unaffected side (0.83 ± 0.19, P < 0.001), the Hypertensive group (0.83 ± 0.17, P < 0.001), and the Normal group (0.69 ± 0.16, P < 0.001). The presence of carotid artery plaque was more frequent in the patients with NAION, compared to either the Hypertensive group (P = 0.001) or the Normal group (P < 0.001). By multiple regression analysis, lower high-density lipoprotein (HDL) (P = 0.009), thicker C-IMT (P = 0.002), CPS Grade = 1 (P = 0.028), and Grade = 2 (P = 0.005) were associated with increased NAION risk, when the NAION group compared with the Hypertensive group (OR > 1.0). Systolic blood pressure (P = 0.001), thicker C-IMT (P < 0.001), CPS Grade = 1 (P = 0.006), Grade = 2 (P = 0.002), and Grade = 3 (P = 0.015) were associated with increased NAION risk, when the NAION group compared with the Normal group (OR > 1.0). CONCLUSIONS: C-IMT and CPS were associated with NAION in hypertensive patients, suggesting that NAION might be associated with carotid artery atherosclerosis. This association may be due to similar pathological changes of the inner vascular walls in the carotid artery and the arteries supplying the optic nerve head. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/28733725/Carotid_artery_intimal_medial_thickness_and_carotid_artery_plaques_in_hypertensive_patients_with_non_arteritic_anterior_ischaemic_optic_neuropathy_ L2 - https://dx.doi.org/10.1007/s00417-017-3744-4 DB - PRIME DP - Unbound Medicine ER -