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Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury.
Dig Dis Sci. 2017 09; 62(9):2223-2230.DD

Abstract

Of the numerous gaseous substances that can act as signaling molecules, the best characterized are nitric oxide, carbon monoxide and hydrogen sulfide. Contributions of each of these low molecular weight substances, alone or in combination, to maintenance of gastrointestinal mucosal integrity have been established. There is considerable overlap in the actions of these gases in modulating mucosal defense and responses to injury, and in some instances they act in a cooperative manner. Each also play important roles in regulating inflammatory and repair processes throughout the gastrointestinal tract. In recent years, significant progress has been made in the development of novel anti-inflammatory and cytoprotective drugs that exploit the beneficial activities of one or more of these gaseous mediators.

Authors+Show Affiliations

Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada. altapharm@hotmail.com. Department of Medicine, Universidade Camilo Castelo Branco, Fernandopolis, SP, Brazil. altapharm@hotmail.com.Department of Experimental Pharmacology, University of Naples, Naples, Italy.Department of Medicine, Universidade Camilo Castelo Branco, Fernandopolis, SP, Brazil.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28733867

Citation

Wallace, John L., et al. "Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury." Digestive Diseases and Sciences, vol. 62, no. 9, 2017, pp. 2223-2230.
Wallace JL, Ianaro A, de Nucci G. Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury. Dig Dis Sci. 2017;62(9):2223-2230.
Wallace, J. L., Ianaro, A., & de Nucci, G. (2017). Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury. Digestive Diseases and Sciences, 62(9), 2223-2230. https://doi.org/10.1007/s10620-017-4681-0
Wallace JL, Ianaro A, de Nucci G. Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury. Dig Dis Sci. 2017;62(9):2223-2230. PubMed PMID: 28733867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury. AU - Wallace,John L, AU - Ianaro,Angela, AU - de Nucci,Gilberto, Y1 - 2017/07/21/ PY - 2017/06/13/received PY - 2017/07/11/accepted PY - 2017/7/25/pubmed PY - 2017/12/8/medline PY - 2017/7/23/entrez KW - Carbon monoxide KW - Colitis KW - Hydrogen sulfide KW - Inflammation KW - Inflammatory bowel disease KW - Mucosal defense KW - Nitric oxide KW - Ulcer SP - 2223 EP - 2230 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 62 IS - 9 N2 - Of the numerous gaseous substances that can act as signaling molecules, the best characterized are nitric oxide, carbon monoxide and hydrogen sulfide. Contributions of each of these low molecular weight substances, alone or in combination, to maintenance of gastrointestinal mucosal integrity have been established. There is considerable overlap in the actions of these gases in modulating mucosal defense and responses to injury, and in some instances they act in a cooperative manner. Each also play important roles in regulating inflammatory and repair processes throughout the gastrointestinal tract. In recent years, significant progress has been made in the development of novel anti-inflammatory and cytoprotective drugs that exploit the beneficial activities of one or more of these gaseous mediators. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/28733867/Gaseous_Mediators_in_Gastrointestinal_Mucosal_Defense_and_Injury_ L2 - https://doi.org/10.1007/s10620-017-4681-0 DB - PRIME DP - Unbound Medicine ER -