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FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder.
Mov Disord. 2017 Oct; 32(10):1482-1486.MD

Abstract

BACKGROUND

Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder.

METHODS

In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent [18] F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included [18] F-fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD-related pattern expression z-scores were computed from all PET scans.

RESULTS

PD-related pattern expression was higher in idiopathic REM sleep behavior disorder subjects compared with controls (P = 0.048), but lower compared with PD (P = 0.001) and dementia with Lewy bodies (P < 0.0001). PD-related pattern expression was higher in idiopathic REM sleep behavior disorder subjects with hyposmia and in subjects with an abnormal dopamine transporter scan (P < 0.05, uncorrected).

CONCLUSION

PD-related pattern expression, dopamine transporter binding, and olfaction may provide complementary information for predicting phenoconversion. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Authors+Show Affiliations

Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Neurology, Philipps-Universität Marburg, Marburg, Germany.Neuroimaging Center, Department of Neuroscience, University of Groningen, Groningen, The Netherlands.Department of Neurology, Philipps-Universität Marburg, Marburg, Germany.Department of Neurology, Philipps-Universität Marburg, Marburg, Germany. Hephata Klinik, Schwalmstadt, Germany.Department of Neurology, Philipps-Universität Marburg, Marburg, Germany.Department of Neurology and JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Aachen University, Aachen, Germany.Kempenhaeghe Foundation, Sleep Medicine Centre, Heeze, The Netherlands.Kempenhaeghe Foundation, Sleep Medicine Centre, Heeze, The Netherlands.Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Nuclear Medicine, Philipps-Universität Marburg, Marburg, Germany.Department of Nuclear Medicine, Philipps-Universität Marburg, Marburg, Germany.Department of Internal Medicine, Section Respiratory Diseases, Philipps Universität Marburg, Marburg, Germany.Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Neurology, Philipps-Universität Marburg, Marburg, Germany. Institute for Neurogenomics, Helmholtz Center for Health and Environment, München, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28734065

Citation

Meles, Sanne K., et al. "FDG PET, Dopamine Transporter SPECT, and Olfaction: Combining Biomarkers in REM Sleep Behavior Disorder." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 32, no. 10, 2017, pp. 1482-1486.
Meles SK, Vadasz D, Renken RJ, et al. FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder. Mov Disord. 2017;32(10):1482-1486.
Meles, S. K., Vadasz, D., Renken, R. J., Sittig-Wiegand, E., Mayer, G., Depboylu, C., Reetz, K., Overeem, S., Pijpers, A., Reesink, F. E., van Laar, T., Heinen, L., Teune, L. K., Höffken, H., Luster, M., Kesper, K., Adriaanse, S. M., Booij, J., Leenders, K. L., & Oertel, W. H. (2017). FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder. Movement Disorders : Official Journal of the Movement Disorder Society, 32(10), 1482-1486. https://doi.org/10.1002/mds.27094
Meles SK, et al. FDG PET, Dopamine Transporter SPECT, and Olfaction: Combining Biomarkers in REM Sleep Behavior Disorder. Mov Disord. 2017;32(10):1482-1486. PubMed PMID: 28734065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder. AU - Meles,Sanne K, AU - Vadasz,David, AU - Renken,Remco J, AU - Sittig-Wiegand,Elisabeth, AU - Mayer,Geert, AU - Depboylu,Candan, AU - Reetz,Kathrin, AU - Overeem,Sebastiaan, AU - Pijpers,Angelique, AU - Reesink,Fransje E, AU - van Laar,Teus, AU - Heinen,Lisette, AU - Teune,Laura K, AU - Höffken,Helmut, AU - Luster,Marcus, AU - Kesper,Karl, AU - Adriaanse,Sofie M, AU - Booij,Jan, AU - Leenders,Klaus L, AU - Oertel,Wolfgang H, Y1 - 2017/07/22/ PY - 2017/02/07/received PY - 2017/05/09/revised PY - 2017/05/26/accepted PY - 2017/7/25/pubmed PY - 2018/6/13/medline PY - 2017/7/23/entrez KW - 18F-FDG-PET KW - Parkinson's disease-related pattern KW - dopamine transporter 123I-FP-CIT SPECT KW - idiopathic REM sleep behavior disorder KW - olfaction SP - 1482 EP - 1486 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 32 IS - 10 N2 - BACKGROUND: Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder. METHODS: In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent [18] F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included [18] F-fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD-related pattern expression z-scores were computed from all PET scans. RESULTS: PD-related pattern expression was higher in idiopathic REM sleep behavior disorder subjects compared with controls (P = 0.048), but lower compared with PD (P = 0.001) and dementia with Lewy bodies (P < 0.0001). PD-related pattern expression was higher in idiopathic REM sleep behavior disorder subjects with hyposmia and in subjects with an abnormal dopamine transporter scan (P < 0.05, uncorrected). CONCLUSION: PD-related pattern expression, dopamine transporter binding, and olfaction may provide complementary information for predicting phenoconversion. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/28734065/FDG_PET_dopamine_transporter_SPECT_and_olfaction:_Combining_biomarkers_in_REM_sleep_behavior_disorder_ DB - PRIME DP - Unbound Medicine ER -