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Aripiprazole prevents renal ischemia/reperfusion injury in rats, probably through nitric oxide involvement.
Eur J Pharmacol. 2017 Oct 15; 813:17-23.EJ

Abstract

Renal ischemia/reperfusion (I/R) injury is strongly related to morbidity and mortality. Oxidative stress, inflammation, and apoptosis play key roles in renal dysfunction following renal I/R. Aripiprazole is an atypical antipsychotic which used for the treatment of schizophrenia and bipolar disorder. Recent studies have reported aripiprazole as displaying certain anti-inflammatory effects. Regarding the underlying mechanisms of renal ischemia-reperfusion, therefore, nephroprotective effects might be predicted to be seen with aripiprazole. I/R injury was induced by bilateral clamping of the renal pedicles (45min) followed by reperfusion (24h). The mechanism of aripiprazole-mediated nephroprotection was explored by a combined use of aripiprazole and L-NAME (non-selective nitric oxide synthase inhibitor). Animals were given aripiprazole (2.5, 5, 10 and 20mg/kg) intraperitoneally, 30min before ischemia. L-NAME was administered before the aripiprazole injection. Serum creatinine and blood urea nitrogen were assessed after 24h of reperfusion. Serum levels of malondialdehyde (MDA), TNF-α and IL-1β were measured for rats treated with aripiprazole. The extent of necrosis was measured by the stereology method. Ischemia/reperfusion caused significant renal dysfunction and marked renal injury. Aripiprazole reduced creatinine and blood urea nitrogen. Serum levels of MDA, IL-1β and TNF-α were significantly lower in the aripiprazole group. Aripiprazole treatment also decreased the volume of kidney necrosis. The administration of L-NAME reversed the renoprotective effect of aripiprazole on BUN and creatinine, but enhanced the anti-necrotic effect of aripiprazole. The results show that a single dose of aripiprazole significantly improved renal function following ischemia/reperfusion injury - probably through the involvement of nitric oxide.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Shafaroodih@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28734929

Citation

Gholampour, Hanieh, et al. "Aripiprazole Prevents Renal Ischemia/reperfusion Injury in Rats, Probably Through Nitric Oxide Involvement." European Journal of Pharmacology, vol. 813, 2017, pp. 17-23.
Gholampour H, Moezi L, Shafaroodi H. Aripiprazole prevents renal ischemia/reperfusion injury in rats, probably through nitric oxide involvement. Eur J Pharmacol. 2017;813:17-23.
Gholampour, H., Moezi, L., & Shafaroodi, H. (2017). Aripiprazole prevents renal ischemia/reperfusion injury in rats, probably through nitric oxide involvement. European Journal of Pharmacology, 813, 17-23. https://doi.org/10.1016/j.ejphar.2017.07.032
Gholampour H, Moezi L, Shafaroodi H. Aripiprazole Prevents Renal Ischemia/reperfusion Injury in Rats, Probably Through Nitric Oxide Involvement. Eur J Pharmacol. 2017 Oct 15;813:17-23. PubMed PMID: 28734929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aripiprazole prevents renal ischemia/reperfusion injury in rats, probably through nitric oxide involvement. AU - Gholampour,Hanieh, AU - Moezi,Leila, AU - Shafaroodi,Hamed, Y1 - 2017/07/19/ PY - 2017/03/08/received PY - 2017/07/15/revised PY - 2017/07/17/accepted PY - 2017/7/25/pubmed PY - 2018/5/3/medline PY - 2017/7/24/entrez KW - Aripiprazole KW - IL-1β KW - Nitric oxide KW - Rat KW - Renal ischemia/reperfusion injury KW - Stereology KW - TNF-α SP - 17 EP - 23 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 813 N2 - Renal ischemia/reperfusion (I/R) injury is strongly related to morbidity and mortality. Oxidative stress, inflammation, and apoptosis play key roles in renal dysfunction following renal I/R. Aripiprazole is an atypical antipsychotic which used for the treatment of schizophrenia and bipolar disorder. Recent studies have reported aripiprazole as displaying certain anti-inflammatory effects. Regarding the underlying mechanisms of renal ischemia-reperfusion, therefore, nephroprotective effects might be predicted to be seen with aripiprazole. I/R injury was induced by bilateral clamping of the renal pedicles (45min) followed by reperfusion (24h). The mechanism of aripiprazole-mediated nephroprotection was explored by a combined use of aripiprazole and L-NAME (non-selective nitric oxide synthase inhibitor). Animals were given aripiprazole (2.5, 5, 10 and 20mg/kg) intraperitoneally, 30min before ischemia. L-NAME was administered before the aripiprazole injection. Serum creatinine and blood urea nitrogen were assessed after 24h of reperfusion. Serum levels of malondialdehyde (MDA), TNF-α and IL-1β were measured for rats treated with aripiprazole. The extent of necrosis was measured by the stereology method. Ischemia/reperfusion caused significant renal dysfunction and marked renal injury. Aripiprazole reduced creatinine and blood urea nitrogen. Serum levels of MDA, IL-1β and TNF-α were significantly lower in the aripiprazole group. Aripiprazole treatment also decreased the volume of kidney necrosis. The administration of L-NAME reversed the renoprotective effect of aripiprazole on BUN and creatinine, but enhanced the anti-necrotic effect of aripiprazole. The results show that a single dose of aripiprazole significantly improved renal function following ischemia/reperfusion injury - probably through the involvement of nitric oxide. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/28734929/Aripiprazole_prevents_renal_ischemia/reperfusion_injury_in_rats_probably_through_nitric_oxide_involvement_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(17)30475-2 DB - PRIME DP - Unbound Medicine ER -