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Exposure to intimate partner violence in utero and infant internalizing behaviors: Moderation by salivary cortisol-alpha amylase asymmetry.
Early Hum Dev. 2017 10; 113:40-48.EH

Abstract

Guided by the main tenets of contemporary models of the developmental origins of health and disease, this study evaluated whether individual differences in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and Sympathetic Nervous System (SNS) moderate the effect of prenatal exposure to trauma on internalizing and externalizing behaviors during infancy. Participants were a community sample of 182 mothers (M age=25years, 43% Caucasian, 33% Black/African American, 24% Biracial/Other) and their infants (59% girls; M age=11.8months). Each mother completed questionnaires that assessed IPV experienced during pregnancy and also reported on her infant's behavior problems. Infant saliva samples (later assayed for cortisol and sAA) were collected before and after a frustrating task (i.e., arm restraint). Results revealed that the association between in utero IPV and infant internalizing behaviors was most pronounced for infants with asymmetrical HPA-SNS (i.e., high-cortisol and low-sAA) reactivity to frustration, and least pronounced for infants with symmetrical HPA-SNS (i.e., low-cortisol and low-sAA or high-cortisol and high-sAA) reactivity to frustration. Higher levels of externalizing behavior, in contrast, were associated with higher levels of prenatal IPV but unrelated to either cortisol or sAA reactivity to stress. Findings replicate documented associations between maternal IPV exposure during pregnancy and offspring risk. Moreover, findings advance our understanding of individual differences in the developmental origins of health and disease and provide additional evidence that assessing multiple stress biomarkers contributes to a more comprehensive understanding of individual vulnerability to adversity.

Authors+Show Affiliations

Department of Psychology, DePaul University, USA. Electronic address: cmart121@depaul.edu.Department of Psychology, Michigan State University, USA.Department of Psychology, Michigan State University, USA.Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, USA; Johns Hopkins University School of Nursing, School of Medicine, and Bloomberg School of Public Health, USA.Department of Psychology, Michigan State University, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28735172

Citation

Martinez-Torteya, Cecilia, et al. "Exposure to Intimate Partner Violence in Utero and Infant Internalizing Behaviors: Moderation By Salivary Cortisol-alpha Amylase Asymmetry." Early Human Development, vol. 113, 2017, pp. 40-48.
Martinez-Torteya C, Bogat GA, Lonstein JS, et al. Exposure to intimate partner violence in utero and infant internalizing behaviors: Moderation by salivary cortisol-alpha amylase asymmetry. Early Hum Dev. 2017;113:40-48.
Martinez-Torteya, C., Bogat, G. A., Lonstein, J. S., Granger, D. A., & Levendosky, A. A. (2017). Exposure to intimate partner violence in utero and infant internalizing behaviors: Moderation by salivary cortisol-alpha amylase asymmetry. Early Human Development, 113, 40-48. https://doi.org/10.1016/j.earlhumdev.2017.07.014
Martinez-Torteya C, et al. Exposure to Intimate Partner Violence in Utero and Infant Internalizing Behaviors: Moderation By Salivary Cortisol-alpha Amylase Asymmetry. Early Hum Dev. 2017;113:40-48. PubMed PMID: 28735172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to intimate partner violence in utero and infant internalizing behaviors: Moderation by salivary cortisol-alpha amylase asymmetry. AU - Martinez-Torteya,Cecilia, AU - Bogat,G Anne, AU - Lonstein,Joseph S, AU - Granger,Douglas A, AU - Levendosky,Alytia A, Y1 - 2017/07/20/ PY - 2017/05/03/received PY - 2017/07/10/revised PY - 2017/07/14/accepted PY - 2017/7/25/pubmed PY - 2018/6/15/medline PY - 2017/7/24/entrez KW - Cortisol KW - Externalizing KW - Internalizing KW - Intimate partner violence KW - Prenatal stress KW - sAA SP - 40 EP - 48 JF - Early human development JO - Early Hum Dev VL - 113 N2 - Guided by the main tenets of contemporary models of the developmental origins of health and disease, this study evaluated whether individual differences in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and Sympathetic Nervous System (SNS) moderate the effect of prenatal exposure to trauma on internalizing and externalizing behaviors during infancy. Participants were a community sample of 182 mothers (M age=25years, 43% Caucasian, 33% Black/African American, 24% Biracial/Other) and their infants (59% girls; M age=11.8months). Each mother completed questionnaires that assessed IPV experienced during pregnancy and also reported on her infant's behavior problems. Infant saliva samples (later assayed for cortisol and sAA) were collected before and after a frustrating task (i.e., arm restraint). Results revealed that the association between in utero IPV and infant internalizing behaviors was most pronounced for infants with asymmetrical HPA-SNS (i.e., high-cortisol and low-sAA) reactivity to frustration, and least pronounced for infants with symmetrical HPA-SNS (i.e., low-cortisol and low-sAA or high-cortisol and high-sAA) reactivity to frustration. Higher levels of externalizing behavior, in contrast, were associated with higher levels of prenatal IPV but unrelated to either cortisol or sAA reactivity to stress. Findings replicate documented associations between maternal IPV exposure during pregnancy and offspring risk. Moreover, findings advance our understanding of individual differences in the developmental origins of health and disease and provide additional evidence that assessing multiple stress biomarkers contributes to a more comprehensive understanding of individual vulnerability to adversity. SN - 1872-6232 UR - https://www.unboundmedicine.com/medline/citation/28735172/Exposure_to_intimate_partner_violence_in_utero_and_infant_internalizing_behaviors:_Moderation_by_salivary_cortisol_alpha_amylase_asymmetry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-3782(17)30215-3 DB - PRIME DP - Unbound Medicine ER -