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Independent associations of dairy and calcium intakes with colorectal cancers in the Adventist Health Study-2 cohort.

Abstract

OBJECTIVE

Results associating dairy and Ca intakes with colorectal cancer (CRC) risk have been mixed. Most previous analyses have suffered from confounding between dairy and Ca intakes. We examined independent associations between these variables, also dairy foods, and CRC incidence in a population with a large range of dairy intakes.

DESIGN

Adventist Health Study-2 is a cohort study where subjects were enrolled 2002-2007. Proportional hazard regression analyses were performed to estimate hazard ratios (HR). Regression calibration was used to correct for dietary measurement error.

SETTING

The population lived in all states of the USA.

SUBJECTS

There were 77712 analytic subjects, all of whom were Seventh-day Adventists. Much of their dietary Ca came from non-dairy sources.

SUBJECTS

During a mean follow-up of 7·8 years, 380 incident colon cancer and 111 incident rectal cancer cases were observed.

RESULTS

Comparing extreme quintiles of intake in measurement error-corrected analyses, dairy intake (HR=0·31; 95 % CI 0·09, 0·88), independent of total Ca, was inversely related with risk of rectal cancer but gave little indication of association with colon cancer. However, total Ca intake (independent of dairy) was associated with risk of colon cancer (HR=0·55; 95 % CI 0·28, 0·98) and there was little indication of association with rectal cancer. Traditional regression analyses and associations with macronutrients from dairy generally supported these results. Milk intake was also negatively associated with CRC (HR=0·63; 95 % CI 0·43, 0·89).

CONCLUSIONS

Dairy intake may decrease the risk of rectal cancer, and Ca may reduce risk of colon cancer and CRC.

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  • Authors+Show Affiliations

    ,

    Adventist Health Study,Loma Linda University,24951 North Circle Drive,NH 2031,Loma Linda,CA 92350,USA.

    ,

    Adventist Health Study,Loma Linda University,24951 North Circle Drive,NH 2031,Loma Linda,CA 92350,USA.

    ,

    Adventist Health Study,Loma Linda University,24951 North Circle Drive,NH 2031,Loma Linda,CA 92350,USA.

    ,

    Adventist Health Study,Loma Linda University,24951 North Circle Drive,NH 2031,Loma Linda,CA 92350,USA.

    ,

    Adventist Health Study,Loma Linda University,24951 North Circle Drive,NH 2031,Loma Linda,CA 92350,USA.

    Adventist Health Study,Loma Linda University,24951 North Circle Drive,NH 2031,Loma Linda,CA 92350,USA.

    Source

    Public health nutrition 20:14 2017 Oct pg 2577-2586

    MeSH

    Adult
    Aged
    Body Mass Index
    Calcium, Dietary
    Cohort Studies
    Colorectal Neoplasms
    Dairy Products
    Diet
    Dietary Carbohydrates
    Dietary Fats
    Dietary Proteins
    Exercise
    Female
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Prospective Studies
    Protestantism
    Risk Factors
    Socioeconomic Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28735581

    Citation

    Tantamango-Bartley, Yessenia, et al. "Independent Associations of Dairy and Calcium Intakes With Colorectal Cancers in the Adventist Health Study-2 Cohort." Public Health Nutrition, vol. 20, no. 14, 2017, pp. 2577-2586.
    Tantamango-Bartley Y, Knutsen SF, Jaceldo-Siegl K, et al. Independent associations of dairy and calcium intakes with colorectal cancers in the Adventist Health Study-2 cohort. Public Health Nutr. 2017;20(14):2577-2586.
    Tantamango-Bartley, Y., Knutsen, S. F., Jaceldo-Siegl, K., Fan, J., Mashchak, A., & Fraser, G. E. (2017). Independent associations of dairy and calcium intakes with colorectal cancers in the Adventist Health Study-2 cohort. Public Health Nutrition, 20(14), pp. 2577-2586. doi:10.1017/S1368980017001422.
    Tantamango-Bartley Y, et al. Independent Associations of Dairy and Calcium Intakes With Colorectal Cancers in the Adventist Health Study-2 Cohort. Public Health Nutr. 2017;20(14):2577-2586. PubMed PMID: 28735581.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Independent associations of dairy and calcium intakes with colorectal cancers in the Adventist Health Study-2 cohort. AU - Tantamango-Bartley,Yessenia, AU - Knutsen,Synnove F, AU - Jaceldo-Siegl,Karen, AU - Fan,Jing, AU - Mashchak,Andrew, AU - Fraser,Gary E, Y1 - 2017/07/24/ PY - 2017/7/25/pubmed PY - 2018/6/14/medline PY - 2017/7/25/entrez KW - Adventist Health Study KW - Calcium KW - Cancer KW - Colon KW - Colorectal KW - Dairy KW - Rectal SP - 2577 EP - 2586 JF - Public health nutrition JO - Public Health Nutr VL - 20 IS - 14 N2 - OBJECTIVE: Results associating dairy and Ca intakes with colorectal cancer (CRC) risk have been mixed. Most previous analyses have suffered from confounding between dairy and Ca intakes. We examined independent associations between these variables, also dairy foods, and CRC incidence in a population with a large range of dairy intakes. DESIGN: Adventist Health Study-2 is a cohort study where subjects were enrolled 2002-2007. Proportional hazard regression analyses were performed to estimate hazard ratios (HR). Regression calibration was used to correct for dietary measurement error. SETTING: The population lived in all states of the USA. SUBJECTS: There were 77712 analytic subjects, all of whom were Seventh-day Adventists. Much of their dietary Ca came from non-dairy sources. SUBJECTS: During a mean follow-up of 7·8 years, 380 incident colon cancer and 111 incident rectal cancer cases were observed. RESULTS: Comparing extreme quintiles of intake in measurement error-corrected analyses, dairy intake (HR=0·31; 95 % CI 0·09, 0·88), independent of total Ca, was inversely related with risk of rectal cancer but gave little indication of association with colon cancer. However, total Ca intake (independent of dairy) was associated with risk of colon cancer (HR=0·55; 95 % CI 0·28, 0·98) and there was little indication of association with rectal cancer. Traditional regression analyses and associations with macronutrients from dairy generally supported these results. Milk intake was also negatively associated with CRC (HR=0·63; 95 % CI 0·43, 0·89). CONCLUSIONS: Dairy intake may decrease the risk of rectal cancer, and Ca may reduce risk of colon cancer and CRC. SN - 1475-2727 UR - https://www.unboundmedicine.com/medline/citation/28735581/Independent_associations_of_dairy_and_calcium_intakes_with_colorectal_cancers_in_the_Adventist_Health_Study_2_cohort_ L2 - https://www.cambridge.org/core/product/identifier/S1368980017001422/type/journal_article DB - PRIME DP - Unbound Medicine ER -