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A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children.
Anaesthesia 2017; 72(10):1191-1195A

Abstract

Chloral hydrate is commonly used to sedate children for painless procedures. Children may recover more quickly after sedation with dexmedetomidine, which has a shorter half-life. We randomly allocated 196 children to chloral hydrate syrup 50 mg.kg-1 and intranasal saline spray, or placebo syrup and intranasal dexmedetomidine spray 3 μg.kg-1 , 30 min before computerised tomography studies. More children resisted or cried after drinking chloral hydrate syrup than placebo syrup, 72 of 107 (67%) vs. 42 of 87 (48%), p = 0.009, but there was no difference after intranasal saline vs. dexmedetomidine, 49 of 107 (46%) vs. 40 of 87 (46%), p = 0.98. Sedation was satisfactory in 81 of 107 (76%) children after chloral hydrate and 64 of 87 (74%) children after dexmedetomidine, p = 0.74. Of the 173 children followed up for at least 4 h after discharge, 38 of 97 (39%) had recovered normal function after chloral hydrate and 32 of 76 (42%) after dexmedetomidine, p = 0.76. Six children vomited after chloral hydrate syrup and placebo spray vs. none after placebo syrup and dexmedetomidine spray, p = 0.03.

Authors+Show Affiliations

Department of Anaesthesiology, Hong Kong Children's Hospital, Hong Kong, China. Department of Anaesthesiology, Queen Mary Hospital, Hong Kong, China.Department of Anaesthesiology, Guangzhou Women and Children's Medical Centre and the Guangzhou Medical University, Guangzhou, China.Department of Paediatric and Adolescent Medicine, Queen Mary Hospital, Hong Kong, China.Department of Anaesthesiology, Queen Mary Hospital, Hong Kong, China.Department of Anaesthesiology, Queen Mary Hospital, Hong Kong, China.UCL School of Pharmacy, London, UK.Department of Radiology, Queen Mary Hospital, Hong Kong, China.Department of Anaesthesiology, University of Hong Kong, Hong Kong, China.Department of Anaesthesiology, University of Hong Kong, Hong Kong, China.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

28741653

Citation

Yuen, V M., et al. "A Randomised Controlled Trial of Oral Chloral Hydrate Vs. Intranasal Dexmedetomidine Before Computerised Tomography in Children." Anaesthesia, vol. 72, no. 10, 2017, pp. 1191-1195.
Yuen VM, Li BL, Cheuk DK, et al. A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children. Anaesthesia. 2017;72(10):1191-1195.
Yuen, V. M., Li, B. L., Cheuk, D. K., Leung, M. K. M., Hui, T. W. C., Wong, I. C., ... Irwin, M. G. (2017). A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children. Anaesthesia, 72(10), pp. 1191-1195. doi:10.1111/anae.13981.
Yuen VM, et al. A Randomised Controlled Trial of Oral Chloral Hydrate Vs. Intranasal Dexmedetomidine Before Computerised Tomography in Children. Anaesthesia. 2017;72(10):1191-1195. PubMed PMID: 28741653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children. AU - Yuen,V M, AU - Li,B L, AU - Cheuk,D K, AU - Leung,M K M, AU - Hui,T W C, AU - Wong,I C, AU - Lam,W W, AU - Choi,S W, AU - Irwin,M G, Y1 - 2017/07/25/ PY - 2017/05/29/accepted PY - 2017/7/26/pubmed PY - 2017/7/26/medline PY - 2017/7/26/entrez KW - chloral hydrate KW - dexmedetomidine KW - intranasal KW - paediatric KW - sedation KW - tomography SP - 1191 EP - 1195 JF - Anaesthesia JO - Anaesthesia VL - 72 IS - 10 N2 - Chloral hydrate is commonly used to sedate children for painless procedures. Children may recover more quickly after sedation with dexmedetomidine, which has a shorter half-life. We randomly allocated 196 children to chloral hydrate syrup 50 mg.kg-1 and intranasal saline spray, or placebo syrup and intranasal dexmedetomidine spray 3 μg.kg-1 , 30 min before computerised tomography studies. More children resisted or cried after drinking chloral hydrate syrup than placebo syrup, 72 of 107 (67%) vs. 42 of 87 (48%), p = 0.009, but there was no difference after intranasal saline vs. dexmedetomidine, 49 of 107 (46%) vs. 40 of 87 (46%), p = 0.98. Sedation was satisfactory in 81 of 107 (76%) children after chloral hydrate and 64 of 87 (74%) children after dexmedetomidine, p = 0.74. Of the 173 children followed up for at least 4 h after discharge, 38 of 97 (39%) had recovered normal function after chloral hydrate and 32 of 76 (42%) after dexmedetomidine, p = 0.76. Six children vomited after chloral hydrate syrup and placebo spray vs. none after placebo syrup and dexmedetomidine spray, p = 0.03. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/28741653/A_randomised_controlled_trial_of_oral_chloral_hydrate_vs__intranasal_dexmedetomidine_before_computerised_tomography_in_children_ L2 - https://doi.org/10.1111/anae.13981 DB - PRIME DP - Unbound Medicine ER -