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Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin.
Mol Nutr Food Res. 2017 11; 61(11)MN

Abstract

SCOPE

Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between vitamin D and inflammation, particularly adipokines, remains unexplored in pregnancy.

METHODS AND RESULTS

In 102 overweight or obese pregnant women at high-risk of gestational diabetes mellitus (GDM), we investigated relationships between maternal 25-hydroxyvitamin D (25(OH)D) concentrations at 12-15 wk gestation (baseline) and serum lipids, inflammatory markers, novel adipokines (omentin-1, visfatin, high molecular weight (HMW) adiponectin), and subsequent pregnancy outcomes (GDM, preeclampsia, preterm birth [PTB]). After adjustment for maternal factors (age, BMI, parity, ethnicity, and smoking status), baseline 25(OH)D concentrations were inversely associated with total cholesterol and triglycerides, and positively associated with HMW-adiponectin. Higher baseline 25(OH)D concentrations were associated with decreased fasting and 1-h post-OGTT glucose and reduced risk of GDM at 26-28 wk, as well as with longer gestation and reduced risk of PTB upon additional adjustment for caesarean section. Adding HMW-adiponectin to the multivariable models attenuated most associations, and HMW-adiponectin was a significant predictor in the models.

CONCLUSION

Our findings suggest that lower maternal 25(OH)D concentrations in overweight/obese pregnant women at high-risk of GDM are associated with increased cardiometabolic risks during pregnancy and adverse pregnancy outcomes, and that these associations may be mediated by HMW-adiponectin.

Authors+Show Affiliations

Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Clayton, Melbourne, Victoria, Australia.Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Clayton, Melbourne, Victoria, Australia.Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Clayton, Melbourne, Victoria, Australia.Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Clayton, Melbourne, Victoria, Australia.Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Clayton, Melbourne, Victoria, Australia.Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Victoria, Australia.Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Victoria, Australia.Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Clayton, Melbourne, Victoria, Australia. Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Victoria, Australia.Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Clayton, Melbourne, Victoria, Australia.Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Clayton, Melbourne, Victoria, Australia.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28741856

Citation

Mousa, Aya, et al. "Relationship Between Vitamin D and Gestational Diabetes in Overweight or Obese Pregnant Women May Be Mediated By Adiponectin." Molecular Nutrition & Food Research, vol. 61, no. 11, 2017.
Mousa A, Abell SK, Shorakae S, et al. Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin. Mol Nutr Food Res. 2017;61(11).
Mousa, A., Abell, S. K., Shorakae, S., Harrison, C. L., Naderpoor, N., Hiam, D., Moreno-Asso, A., Stepto, N. K., Teede, H. J., & de Courten, B. (2017). Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin. Molecular Nutrition & Food Research, 61(11). https://doi.org/10.1002/mnfr.201700488
Mousa A, et al. Relationship Between Vitamin D and Gestational Diabetes in Overweight or Obese Pregnant Women May Be Mediated By Adiponectin. Mol Nutr Food Res. 2017;61(11) PubMed PMID: 28741856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin. AU - Mousa,Aya, AU - Abell,Sally K, AU - Shorakae,Soulmaz, AU - Harrison,Cheryce L, AU - Naderpoor,Negar, AU - Hiam,Danielle, AU - Moreno-Asso,Alba, AU - Stepto,Nigel K, AU - Teede,Helena J, AU - de Courten,Barbora, Y1 - 2017/08/23/ PY - 2017/06/04/received PY - 2017/07/13/revised PY - 2017/07/17/accepted PY - 2017/7/26/pubmed PY - 2018/6/30/medline PY - 2017/7/26/entrez KW - Adipokines KW - Cardiometabolic risk factors KW - Gestational diabetes mellitus KW - Pregnancy KW - Vitamin D JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 61 IS - 11 N2 - SCOPE: Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between vitamin D and inflammation, particularly adipokines, remains unexplored in pregnancy. METHODS AND RESULTS: In 102 overweight or obese pregnant women at high-risk of gestational diabetes mellitus (GDM), we investigated relationships between maternal 25-hydroxyvitamin D (25(OH)D) concentrations at 12-15 wk gestation (baseline) and serum lipids, inflammatory markers, novel adipokines (omentin-1, visfatin, high molecular weight (HMW) adiponectin), and subsequent pregnancy outcomes (GDM, preeclampsia, preterm birth [PTB]). After adjustment for maternal factors (age, BMI, parity, ethnicity, and smoking status), baseline 25(OH)D concentrations were inversely associated with total cholesterol and triglycerides, and positively associated with HMW-adiponectin. Higher baseline 25(OH)D concentrations were associated with decreased fasting and 1-h post-OGTT glucose and reduced risk of GDM at 26-28 wk, as well as with longer gestation and reduced risk of PTB upon additional adjustment for caesarean section. Adding HMW-adiponectin to the multivariable models attenuated most associations, and HMW-adiponectin was a significant predictor in the models. CONCLUSION: Our findings suggest that lower maternal 25(OH)D concentrations in overweight/obese pregnant women at high-risk of GDM are associated with increased cardiometabolic risks during pregnancy and adverse pregnancy outcomes, and that these associations may be mediated by HMW-adiponectin. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/28741856/Relationship_between_vitamin_D_and_gestational_diabetes_in_overweight_or_obese_pregnant_women_may_be_mediated_by_adiponectin_ L2 - https://doi.org/10.1002/mnfr.201700488 DB - PRIME DP - Unbound Medicine ER -